Research output per year
Research output per year
Unit profile
Research
In our group we are interested in how aging and neurodegenerative diseases affect the brain, neural cells and neural stem cells. Using novel stem cell, reprogramming and genome editing technologies we are studying how genetic pathways involved in aging and neurodegenerative disease affect formation and function of neural cells. We also have a strong interest in basic stem cell biology with a clear focus on neural stem cells and neurogenesis in the adult and aging brain. Therefore, our aims are to develop cellular models of human neural aging and degeneration, to investigate underlying mechanisms responsible for dysfunction in neural and neural stem cells in the aging and diseased brain and to dissect the regulation of normal neurogenesis.
UKÄ subject classification
- Neurology
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Henrik Ahlenius
- Stem Cells, Aging and Neurodegeneration - Research team manager, Senior lecturer
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Principal investigator
- LUCC: Lund University Cancer Centre - Principal investigator
- MultiPark: Multidisciplinary research focused on Parkinson´s disease - Principal investigator
Person
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Jonas Fritze
- Stem Cells, Aging and Neurodegeneration - Research student
- Neurology, Lund - Doctoral student
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Doctoral student
Person
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Enrico Pracucci
- Stem Cells, Aging and Neurodegeneration - Postdoctoral fellow
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Postdoctoral fellow
Person
Research output
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Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo
Trovato, F., Stefani, F. R., Li, J., Zetterdahl, O. G., Canals, I., Ahlenius, H. & Bengzon, J., 2023 Feb 1, In: Molecular Cancer Therapeutics. 22, 2, p. 274-286Research output: Contribution to journal › Article › peer-review
Open Access -
Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine
Gioia, R., Seri, T., Diamanti, T., Fimmanò, S., Vitale, M., Ahlenius, H., Kokaia, Z., Tirone, F., Micheli, L., Biagioni, S., Lupo, G., Rinaldi, A., De Jaco, A. & Cacci, E., 2023, In: Journal of Neurochemistry. 165, 3, p. 318-333Research output: Contribution to journal › Article › peer-review
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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
Canals, I., Comella-Bolla, A., Cepeda-Prado, E., Avaliani, N., Crowe, J. A., Oburoglu, L., Bruzelius, A., King, N., Pajares, M. A., Pérez-Sala, D., Heuer, A., Rylander Ottosson, D., Soriano, J. & Ahlenius, H., 2023, In: Brain Communications. 5, 3, p. 1-16 fcad158.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 7 Active
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Modeller och behandling av cancer i hjärnan med hjälp av stamceller, omprogrammering och genteknik
2024/01/01 → 2027/12/31
Project: Research
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Cellular reprogramming: a novel treatment for glioblastoma
Familjen Erling-Perssons Stiftelse
2023/03/01 → 2025/12/31
Project: Research
Activities
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Neuroscience Day 2024
Anders Björklund (Member of programme committee), Christine Ekdahl Clementson (Member of programme committee), Martin Garwicz (Member of programme committee), Bo Norrving (Member of programme committee), Malin Parmar (Member of programme committee), Åsa Petersén (Member of programme committee), Oskar Hansson (Member of programme committee), MARIA COMPAGNO STRANDBERG (Member of programme committee), Daniella Ottosson (Member of programme committee), Andreas Heuer (Member of programme committee), Merab Kokaia (Member of programme committee), Johan Mårtensson (Member of programme committee), Laura Castilla-Vallmanya (Member of programme committee), Paulina Pettersson (Organiser), Johan Jakobsson (Chair), Laura Castilla-Vallmanya (Organiser), Daniel Patrick Twohig (Contributor), Valentina Cesaroni (Contributor), Rosalia Fernandez Calle (Contributor), Ernest Arenas (Invited speaker), Gabriele Lignani (Invited speaker), Anna Beyeler (Invited speaker), Anita Adami (Presenter), Sofia Bergh (Presenter), Jonas Fritze (Presenter), Alice Hägg (Presenter), Jari Jukkola (Presenter), Edoardo Sozzi (Presenter), Juliane Tampé (Presenter), Anne Schaefer (Keynote/plenary speaker), Mette Habekost (Chair) & Jenny Wickham (Chair)
2024 May 7Activity: Participating in or organising an event › Organisation of conference
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UniStem Day 2024: Dissemination and outreach of stem cell science
Daniella Ottosson (Organiser), Mattias Magnusson (Organiser), Srisaiyini Kidnapillai (Organiser), Henrik Ahlenius (Organiser), Alexis Bento Luis (Organiser), Raquel Martinez Curiel (Organiser), Kerstin Laurin (Organiser), Paula Martos Salvo (Organiser), Moubani Das (Contributor), Markus Wendler (Contributor), Bala Mohan Sivani (Contributor), Germán Ramos Passarello (Contributor), Edoardo Sozzi (Contributor), María García Garrote (Contributor), Chimezie Harrison Umeano (Contributor), Ugonna Chidiebere Okeke (Contributor), Vivien Horvath (Contributor), Raquel Garza (Contributor), Anita Adami (Contributor), Laura Castilla-Vallmanya (Contributor), Patricia Gerdes (Contributor), Ninoslav Pandiloski (Contributor), Qianren Jin (Contributor), Claudia de Guidi (Contributor), Sara Palma Tortosa (Contributor), Jonas Fritze (Contributor), Linda I Jansson (Contributor), Laura Robles Rodriguez (Contributor), Enrico Pracucci (Contributor), Yu-Ping Shen (Contributor), Francesco Trovato (Contributor), Juliane Tampé (Contributor), Radhika Thakore (Contributor), Christina-Anastasia Stamouli (Contributor), Cristiana Pinto dos Santos Vaz (Contributor), Constanza Aretio (Contributor), Claire Piochon (Contributor), Efrain Cepeda-Prado (Contributor), Max-Michael de Jongh (Contributor), Maria Tsalkitzidou (Contributor), Jana Bonsberger (Contributor), Christopher Douse (Contributor), Fereshteh Dorazehi (Contributor), Symela Koutounidou (Contributor), Ulla Jarl (Contributor), Sara Corsi (Contributor), Andreas Bruzelius (Contributor), Bengt Mattsson (Contributor), Anna Hammarberg (Contributor), Mette Habekost (Contributor), Pavan Prabhala (Contributor), Tyra Bremborg (Contributor), Malavika Sreekumar Nair (Contributor), Perrine Burdeyron (Contributor), Marina Mazariegos (Contributor), Maria Björklund (Contributor), Isabel Hidalgo (Contributor), Alice Hägg (Invited speaker), Emma Hammarlund (Invited speaker), Sofie Mohlin (Invited speaker) & Marlene Oesterle (Contributor)
2024 Mar 22Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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LUCC - CNS: Transcription-factor mediated reprogramming of GBM - Seminar
Alexander Pietras (Organiser), Mattias Belting (Organiser) & Francesco Trovato (Speaker)
2022 Mar 25Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course