Research output per year
Research output per year
Unit profile
Research
In our group we are interested in how aging and neurodegenerative diseases affect the brain, neural cells and neural stem cells. Using novel stem cell, reprogramming and genome editing technologies we are studying how genetic pathways involved in aging and neurodegenerative disease affect formation and function of neural cells. We also have a strong interest in basic stem cell biology with a clear focus on neural stem cells and neurogenesis in the adult and aging brain. Therefore, our aims are to develop cellular models of human neural aging and degeneration, to investigate underlying mechanisms responsible for dysfunction in neural and neural stem cells in the aging and diseased brain and to dissect the regulation of normal neurogenesis.UKÄ subject classification
- Neurology
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Henrik Ahlenius
- Stem Cells, Aging and Neurodegeneration - Research team manager, Senior lecturer
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Principal investigator
- LUCC: Lund University Cancer Centre - Principal investigator
- MultiPark: Multidisciplinary research focused on Parkinson´s disease - Principal investigator
Person
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Jonas Fritze
- Stem Cells, Aging and Neurodegeneration - Research student
- Neurology, Lund - Doctoral student
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Doctoral student
Person
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Enrico Pracucci
- Stem Cells, Aging and Neurodegeneration - Postdoctoral fellow
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Postdoctoral fellow
Person
Research output
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Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine
Gioia, R., Seri, T., Diamanti, T., Fimmanò, S., Vitale, M., Ahlenius, H., Kokaia, Z., Tirone, F., Micheli, L., Biagioni, S., Lupo, G., Rinaldi, A., De Jaco, A. & Cacci, E., 2023, In: Journal of Neurochemistry. 165, 3, p. 318-333Research output: Contribution to journal › Article › peer-review
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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
Canals, I., Comella-Bolla, A., Cepeda-Prado, E., Avaliani, N., Crowe, J. A., Oburoglu, L., Bruzelius, A., King, N., Pajares, M. A., Pérez-Sala, D., Heuer, A., Rylander Ottosson, D., Soriano, J. & Ahlenius, H., 2023, In: Brain Communications. 5, 3, p. 1-16 fcad158.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of human astrocytes for disease modeling. A study based on stem cells, direct conversion and genome engineering to dissect the role of astrocytes in leukodystrophies
Quist, E., 2023, Lund: Lund University, Faculty of Medicine. 92 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile
Projects
- 5 Active
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Cellular reprogramming: a novel treatment for glioblastoma
Familjen Erling-Perssons Stiftelse
2023/03/01 → 2025/12/31
Project: Research
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Activities
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LUCC - CNS: Transcription-factor mediated reprogramming of GBM - Seminar
Alexander Pietras (Organiser), Mattias Belting (Organiser) & Francesco Trovato (Speaker)
2022 Mar 25Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Unistem Day 2020
Göran Karlsson (Organiser), Christine Karlsson (Organiser), Paulina Pettersson (Organiser), Claire McKay (Organiser), Henrik Ahlenius (Organiser), Malin Parmar (Organiser), Mattias Magnusson (Organiser), Rebecca Warfvinge (Organiser), Sara Nolbrant (Speaker), Pia Johansson (Contributor), Diahann Atacho (Contributor), Shelby Shrigley (Contributor), Ulla Jarl (Contributor), Michael Sparrenius (Contributor), Bengt Mattsson (Contributor), Deirdre Hoban (Contributor), Alessandro Fiorenzano (Contributor), Jessica Giacomoni (Contributor), Fredrik Nilsson (Contributor), Edoardo Sozzi (Contributor), Anna Hammarberg (Contributor), Karolina Pircs (Contributor), Andreas Bruzelius (Contributor), Marcella Birtele (Contributor), Shayini Kidnapillai (Contributor), Efrain Cepeda-Prado (Contributor), Katharina Mikulik (Contributor), Raquel Garza (Contributor) & Petter Storm (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Neuroscience Day 2019
Paulina Pettersson (Organiser), Anders Björklund (Member of programme committee), Christine Ekdahl Clementson (Member of programme committee), Martin Garwicz (Member of programme committee), Måns Magnusson (Member of programme committee), Bo Norrving (Member of programme committee), Malin Parmar (Member of programme committee), Åsa Petersén (Member of programme committee), Oskar Hansson (Member of programme committee), MARIA COMPAGNO STRANDBERG (Member of programme committee), Marcella Birtele (Presenter), Ella Quist (Presenter), Alexander Lind (Presenter), Jonas Fritze (Presenter), Laura Andreoli (Presenter) & Sara Nolbrant (Presenter)
2019 May 9Activity: Participating in or organising an event › Participation in conference
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