Research output per year
Research output per year
Unit profile
Research
In our group we are interested in how aging and neurodegenerative diseases affect the brain, neural cells and neural stem cells. Using novel stem cell, reprogramming and genome editing technologies we are studying how genetic pathways involved in aging and neurodegenerative disease affect formation and function of neural cells. We also have a strong interest in basic stem cell biology with a clear focus on neural stem cells and neurogenesis in the adult and aging brain. Therefore, our aims are to develop cellular models of human neural aging and degeneration, to investigate underlying mechanisms responsible for dysfunction in neural and neural stem cells in the aging and diseased brain and to dissect the regulation of normal neurogenesis.
Subject classification (UKÄ)
- Neurology
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Henrik Ahlenius
- Stem Cells, Aging and Neurodegeneration - Research team manager, Senior lecturer
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Member of Strategic Research Area
- LUCC: Lund University Cancer Centre - Principal investigator
- MultiPark: Multidisciplinary research on neurodegenerative diseases - Member of Strategic Research Area
Person
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Enrico Pracucci
- Stem Cells, Aging and Neurodegeneration - Postdoc
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Member of Strategic Research Area
- MultiPark: Multidisciplinary research on neurodegenerative diseases - Member of Strategic Research Area
Person
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Laura Robles Rodríguez
- Stem Cells, Aging and Neurodegeneration - Postdoc
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Member of Strategic Research Area
- MultiPark: Multidisciplinary research on neurodegenerative diseases - Member of Strategic Research Area
Person
Research output
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Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders
Zetterdahl, O. G., Crowe, J. A., Reyhani, S., Güra, M. A., Labastida-Botey, O., Girard, A. S., Froese, D. S., Ahlenius, H. & Canals, I., 2025 Jun, In: eNeuro. 12, 6Research output: Contribution to journal › Article › peer-review
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Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease
Matusova, Z., Dykstra, W., de Pablo, Y., Zetterdahl, O. G., Canals, I., van Gelder, C. A. G. H., Vos, H. R., Pérez-Sala, D., Kubista, M., Abaffy, P., Ahlenius, H., Valihrach, L., Hol, E. M. & Pekny, M., 2025, In: GLIA. 73, 1, p. 57-79Research output: Contribution to journal › Article › peer-review
Open Access -
Leveraging genome engineering and stem cells to study rare pediatric CNS disorders
Zetterdahl, O. G., 2025, Lund: Lund University, Faculty of Medicine. 118 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile
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Glial Interactions in Initiation and Progression of AD - Disease Mechanisms and Bio markers
Ahlenius, H. (PI)
2024/12/17 → 2026/12/31
Project: Research
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Modeller och behandling av cancer i hjärnan med hjälp av stamceller, omprogrammering och genteknik
Ahlenius, H. (Researcher)
2024/01/01 → 2027/12/31
Project: Research
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Neural Cell Dysfunction in Aging and Neurodegeneration
Ahlenius, H. (Researcher)
2024/01/01 → 2027/12/31
Project: Research
Activities
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LUCC - CNS Webinar: "A Human Organoid Model of Pilocytic Astrocytoma Reveals BRAF-Driven Developmental Shifts"
Pietras, A. (Organiser), Bengzon, J. (Organiser) & Trovato, F. (Invited speaker)
2025 May 28Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Neuroscience Day 2024
Björklund, A. (Member of programme committee), Ekdahl Clementson, C. (Member of programme committee), Garwicz, M. (Member of programme committee), Norrving, B. (Member of programme committee), Parmar, M. (Member of programme committee), Petersén, Å. (Member of programme committee), Hansson, O. (Member of programme committee), COMPAGNO STRANDBERG, M. (Member of programme committee), Ottosson, D. (Member of programme committee), Heuer, A. (Member of programme committee), Kokaia, M. (Member of programme committee), Mårtensson, J. (Member of programme committee), Castilla-Vallmanya, L. (Member of programme committee), Pettersson, P. (Organiser), Jakobsson, J. (Chair), Castilla-Vallmanya, L. (Organiser), Twohig, D. P. (Contributor), Cesaroni, V. (Contributor), Fernandez Calle, R. (Contributor), Arenas, E. (Invited speaker), Lignani, G. (Invited speaker), Beyeler, A. (Invited speaker), Adami, A. (Presenter), Bergh, S. (Presenter), Fritze, J. (Presenter), Hägg, A. (Presenter), Jukkola, J. (Presenter), Sozzi, E. (Presenter), Tampé, J. (Presenter), Schaefer, A. (Keynote/plenary speaker), Habekost, M. (Chair) & Wickham, J. (Chair)
2024 May 7Activity: Participating in or organising an event › Organisation of conference
File -
UniStem Day 2024: Dissemination and outreach of stem cell science
Ottosson, D. (Organiser), Magnusson, M. (Organiser), Kidnapillai, S. (Organiser), Ahlenius, H. (Organiser), Luis, A. B. (Organiser), Martinez Curiel, R. (Organiser), Laurin, K. (Organiser), Martos Salvo, P. (Organiser), Das, M. (Contributor), Wendler, M. (Contributor), Sivani, B. M. (Contributor), Ramos Passarello, G. (Contributor), Sozzi, E. (Contributor), García Garrote, M. (Contributor), Harrison Umeano, C. (Contributor), Okeke, U. C. (Contributor), Horvath, V. (Contributor), Garza, R. (Contributor), Adami, A. (Contributor), Castilla-Vallmanya, L. (Contributor), Gerdes, P. (Contributor), Pandiloski, N. (Contributor), Jin, Q. (Contributor), de Guidi, C. (Contributor), Palma Tortosa, S. (Contributor), Fritze, J. (Contributor), Jansson, L. I. (Contributor), Robles Rodriguez, L. (Contributor), Pracucci, E. (Contributor), Shen, Y.-P. (Contributor), Trovato, F. (Contributor), Tampé, J. (Contributor), Thakore, R. (Contributor), Stamouli, C.-A. (Contributor), Pinto dos Santos Vaz, C. (Contributor), Aretio, C. (Contributor), Piochon, C. (Contributor), Cepeda-Prado, E. (Contributor), de Jongh, M.-M. (Contributor), Tsalkitzidou, M. (Contributor), Bonsberger, J. (Contributor), Douse, C. (Contributor), Dorazehi, F. (Contributor), Koutounidou, S. (Contributor), Jarl, U. (Contributor), Corsi, S. (Contributor), Bruzelius, A. (Contributor), Mattsson, B. (Contributor), Hammarberg, A. (Contributor), Habekost, M. (Contributor), Prabhala, P. (Contributor), Bremborg, T. (Contributor), Nair, M. S. (Contributor), Burdeyron, P. (Contributor), Mazariegos, M. (Contributor), Björklund, M. (Contributor), Hidalgo, I. (Contributor), Hägg, A. (Invited speaker), Hammarlund, E. (Invited speaker), Mohlin, S. (Invited speaker) & Oesterle, M. (Contributor)
2024 Mar 22Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course