Research output per year
Research output per year
Unit profile
Research
The production of blood cells, hematopoiesis, is maintained by a small number of hematopoietic stem cells (HSCs) that have the capacity to differentiate into all hematopoietic lineages, and at the same time self-renew to maintain the HSC pool. Similarly to normal hematopoiesis, leukemias are organized in cellular hierarchies where leukemic stem cells (LSCs) drive tumor growth. LSCs have stem cell characteristics such as self-renewal capacity, quiescence and drug resistance, causing metastasis and relapse. LSCs are therefore a critical priority as targets for therapy. Our objective is to use single-cell methods to dissect the heterogeneity of stem cell populations and discriminate between HSCs and LSCs. This will allow for defining the transcriptional programs that govern HSC fate and explain the molecular basis for leukemogenesis as well as therapy resistance. Ultimately we will use this information to therapeutically target LSCs and thereby improve the treatment of leukemia.
Subject classification (UKÄ)
- Basic Cancer Research
Free keywords
- Hematopoiesis
- Leukemia
- Stem Cells
- Single-Cell Analysis
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Linda Geironson Ulfsson
- Division of Molecular Hematology (DMH) - Research engineer
- Stem Cells and Leukemia - Research engineer
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Research engineer
Person
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Göran Karlsson
- Division of Molecular Hematology (DMH)
- Stem Cells and Leukemia - Research team manager
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Principal investigator
Person
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Ram Krishna Thakur
- Division of Molecular Hematology (DMH) - Associate researcher
- Stem Cells and Leukemia - Associate researcher
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Associate researcher
Person
Research output
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Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response
Warfvinge, R., Geironson Ulfsson, L., Dhapola, P., Safi, F., Sommarin, M., Soneji, S., Hjorth-Hansen, H., Mustjoki, S., Richter, J., Thakur, R. K. & Karlsson, G., 2024 Nov 6, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
Huuhtanen, J., Adnan-Awad, S., Theodoropoulos, J., Forstén, S., Warfvinge, R., Dufva, O., Bouhlal, J., Dhapola, P., Duàn, H., Laajala, E., Kasanen, T., Klievink, J., Ilander, M., Jaatinen, T., Olsson-Strömberg, U., Hjorth-Hansen, H., Burchert, A., Karlsson, G., Kreutzman, A. & Lähdesmäki, H. & 1 others, , 2024, In: Leukemia. 38, 1, p. 109–125 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response
Fritze, J., Lang, S., Sommarin, M., Soneji, S. & Ahlenius, H., 2024, In: Frontiers in Neuroscience. 18, 1400963.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active
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Single-cell analysis of leukemic stem cells to predict therapy insensitivity and relapse
Karlsson, G. (PI)
2024/01/01 → 2027/12/31
Project: Research
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LUCC - Blood, lymphoma & myeloma: Chronic Myeloid Leukemia - Seminar
Hagström-Andersson, A. (Organiser), Scheding, S. (Organiser), Fager Ferrari, M. (Invited speaker) & Karlsson, G. (Invited speaker)
2023 Feb 16Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Unistem Day 2020
Karlsson, G. (Organiser), Karlsson, C. (Organiser), Pettersson, P. (Organiser), McKay, C. (Organiser), Ahlenius, H. (Organiser), Parmar, M. (Organiser), Magnusson, M. (Organiser), Warfvinge, R. (Organiser), Nolbrant, S. (Speaker), Johansson, P. (Contributor), Atacho, D. (Contributor), Shrigley, S. (Contributor), Jarl, U. (Contributor), Sparrenius, M. (Contributor), Mattsson, B. (Contributor), Hoban, D. (Contributor), Fiorenzano, A. (Contributor), Giacomoni, J. (Contributor), Nilsson, F. (Contributor), Sozzi, E. (Contributor), Hammarberg, A. (Contributor), Pircs, K. (Contributor), Bruzelius, A. (Contributor), Birtele, M. (Contributor), Kidnapillai, S. (Contributor), Cepeda-Prado, E. (Contributor), Mikulik, K. (Contributor), Garza, R. (Contributor) & Storm, P. (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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