Research output per year
Research output per year
Unit profile
Research
The production of blood cells, hematopoiesis, is maintained by a small number of hematopoietic stem cells (HSCs) that have the capacity to differentiate into all hematopoietic lineages, and at the same time self-renew to maintain the HSC pool. Similarly to normal hematopoiesis, leukemias are organized in cellular hierarchies where leukemic stem cells (LSCs) drive tumor growth. LSCs have stem cell characteristics such as self-renewal capacity, quiescence and drug resistance, causing metastasis and relapse. LSCs are therefore a critical priority as targets for therapy. Our objective is to use single-cell methods to dissect the heterogeneity of stem cell populations and discriminate between HSCs and LSCs. This will allow for defining the transcriptional programs that govern HSC fate and explain the molecular basis for leukemogenesis as well as therapy resistance. Ultimately we will use this information to therapeutically target LSCs and thereby improve the treatment of leukemia.Description
Göran Karlsson is Research Group Leader for this research groupUKÄ subject classification
- Cancer and Oncology
Free keywords
- Hematopoiesis
- Leukemia
- Stem Cells
- Single-Cell Analysis
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Linda Geironson Ulfsson
- Division of Molecular Hematology (DMH) - Research engineer
- Stem Cells and Leukemia - Research engineer
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Research engineer
Person
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Göran Karlsson
- Division of Molecular Hematology (DMH)
- Stem Cells and Leukemia - Research team manager
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Principal investigator
Person
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Fatemeh Safi
- Division of Molecular Hematology (DMH) - Doctoral student
- Stem Cells and Leukemia - Doctoral student
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Doctoral student
Person
Research output
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Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays.
Safi, F., 2023, Lund: Lund University, Faculty of Medicine. 107 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile -
Human Bone Marrow Microenvironment in Health and Disease
Bräunig, S., 2023, Lund: Lund University, Faculty of Medicine. 89 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile -
Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing
Li, H., Bräunig, S., Dhapolar, P., Karlsson, G., Lang, S. & Scheding, S., 2023, In: eLife. 12, e81656.Research output: Contribution to journal › Article › peer-review
Open Access
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LUCC - Blood, lymphoma & myeloma: Chronic Myeloid Leukemia - Seminar
Anna Hagström-Andersson (Organiser), Stefan Scheding (Organiser), Marcus Fager Ferrari (Invited speaker) & Göran Karlsson (Invited speaker)
2023 Feb 16Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Unistem Day 2020
Göran Karlsson (Organiser), Christine Karlsson (Organiser), Paulina Pettersson (Organiser), Claire McKay (Organiser), Henrik Ahlenius (Organiser), Malin Parmar (Organiser), Mattias Magnusson (Organiser), Rebecca Warfvinge (Organiser), Sara Nolbrant (Speaker), Pia Johansson (Contributor), Diahann Atacho (Contributor), Shelby Shrigley (Contributor), Ulla Jarl (Contributor), Michael Sparrenius (Contributor), Bengt Mattsson (Contributor), Deirdre Hoban (Contributor), Alessandro Fiorenzano (Contributor), Jessica Giacomoni (Contributor), Fredrik Nilsson (Contributor), Edoardo Sozzi (Contributor), Anna Hammarberg (Contributor), Karolina Pircs (Contributor), Andreas Bruzelius (Contributor), Marcella Birtele (Contributor), Shayini Kidnapillai (Contributor), Efrain Cepeda-Prado (Contributor), Katharina Mikulik (Contributor), Raquel Garza (Contributor) & Petter Storm (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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