Research output per year
Research output per year
Research output
- 33 results
Search results
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2024
Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
Huuhtanen, J., Adnan-Awad, S., Theodoropoulos, J., Forstén, S., Warfvinge, R., Dufva, O., Bouhlal, J., Dhapola, P., Duàn, H., Laajala, E., Kasanen, T., Klievink, J., Ilander, M., Jaatinen, T., Olsson-Strömberg, U., Hjorth-Hansen, H., Burchert, A., Karlsson, G., Kreutzman, A. & Lähdesmäki, H. & 1 others, , 2024, In: Leukemia. 38, 1, p. 109–125 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Single-cell multiomics of human fetal hematopoiesis define a developmental-specific population and a fetal signature
Sommarin, M. N. E., Olofzon, R., Palo, S., Dhapola, P., Soneji, S., Karlsson, G. & Böiers, C., 2023 Sept, In: Blood Advances. 7, 18, p. 5325-5340 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations
Safi, F., Dhapola, P., Erlandsson, E., Ulfsson, L. G., Calderón, A. S., Böiers, C. & Karlsson, G., 2023 Mar 17, In: STAR Protocols. 4, 1, 101965.Research output: Contribution to journal › Article › peer-review
Open Access -
Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays.
Safi, F., 2023, Lund: Lund University, Faculty of Medicine. 107 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile220 Downloads (Pure) -
Human Bone Marrow Microenvironment in Health and Disease
Bräunig, S., 2023, Lund: Lund University, Faculty of Medicine. 89 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile233 Downloads (Pure) -
Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing
Li, H., Bräunig, S., Dhapolar, P., Karlsson, G., Lang, S. & Scheding, S., 2023, In: eLife. 12, e81656.Research output: Contribution to journal › Article › peer-review
Open Access -
Pediatric Leukemia: Mechanisms of Initiation and Suppression
Eldeeb, M., 2023, Lund: Lund University, Faculty of Medicine. 94 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile202 Downloads (Pure) -
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age
Konturek-Ciesla, A., Dhapola, P., Zhang, Q., Säwén, P., Wan, H., Karlsson, G. & Bryder, D., 2023, In: Cell Reports. 42, 4, 112304.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction
Safi, F., Dhapola, P., Warsi, S., Sommarin, M., Erlandsson, E., Ungerbäck, J., Warfvinge, R., Sitnicka, E., Bryder, D., Böiers, C., Thakur, R. K. & Karlsson, G., 2022 May 10, In: Cell Reports. 39, 6, 110798.Research output: Contribution to journal › Article › peer-review
Open Access -
Genome-wide association study on 13 167 individuals identifies regulators of blood CD34+cell levels
Lopez de Lapuente Portilla, A., Ekdahl, L., Cafaro, C., Ali, Z., Miharada, N., Thorleifsson, G., Žemaitis, K., Lamarca Arrizabalaga, A., Thodberg, M., Pertesi, M., Dhapola, P., Bao, E., Niroula, A., Bali, D., Norddahl, G., Ugidos Damboriena, N., Sankaran, V. G., Karlsson, G., Thorsteinsdottir, U. & Larsson, J. & 2 others, , 2022 Mar 17, In: Blood. 139, 11, p. 1659-1669 11 p.Research output: Contribution to journal › Article › peer-review
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Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems
Dhapola, P., 2022, Lund: Lund University, Faculty of Medicine. 91 p.Research output: Thesis › Doctoral Thesis (compilation)
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Novel Insights into Haematopoietic Stem Cell Regulation and Function
Warsi, S., 2022, Lund: Lund University, Faculty of Medicine. 82 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile185 Downloads (Pure) -
Scarf enables a highly memory-efficient analysis of large-scale single-cell genomics data
Dhapola, P., Rodhe, J., Olofzon, R., Bonald, T., Erlandsson, E., Soneji, S. & Karlsson, G., 2022, In: Nature Communications. 13, 4616.Research output: Contribution to journal › Article › peer-review
Open Access -
Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells
Warsi, S., Dahl, M., Smith, E. M. K., Rydström, A., Mansell, E., Sigurdsson, V., Sjöberg, J., Soneji, S., Rörby, E., Siva, K., Grahn, T. H. M., Liu, Y., Blank, U., Karlsson, G. & Karlsson, S., 2022, In: Haematologica. 107, 12, p. 2884-2896 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
CellexalVR: A virtual reality platform to visualize and analyze single-cell omics data
Legetth, O., Rodhe, J., Lang, S., Dhapola, P., Wallergård, M. & Soneji, S., 2021 Nov, In: iScience. 24, 11, 103251.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs
Pfisterer, U., Bräunig, J., Brattås, P., Heidenblad, M., Karlsson, G. & Fioretos, T., 2021 Jul 1, In: Genes, Chromosomes and Cancer. 60, 7, p. 504-524 21 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Genome-wide association study on 13,167 individuals identifies regulators of hematopoietic stem and progenitor cell levels in human blood
Lopez de Lapuente Portilla, A., Ekdahl, L., Cafaro, C., Ali, Z., Miharada, N., Thorleifsson, G., Zemaitis, K., Lamarca Arrizabalaga, A., Thodberg, M., Pertesi, M., Dhapola, P., Bao, E. L., Niroula, A., Bali, D., Norddahl, G. L., Ugidos Damboriena, N., Sankaran, V. G., Karlsson, G., Thorsteinsdottir, U. & Larsson, J. & 2 others, , 2021 Apr 3, bioRxiv.Research output: Working paper/Preprint › Preprint (in preprint archive)
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Defining the Emerging Blood System During Development at Single-Cell Resolution
Karlsson, G., Sommarin, M. N. E. & Böiers, C., 2021, In: Frontiers in Cell and Developmental Biology. 9, 660350.Research output: Contribution to journal › Review article › peer-review
Open Access -
Human Primary Airway Basal Cells Display a Continuum of Molecular Phases from Health to Disease in Chronic Obstructive Pulmonary Disease
Wijk, S. C., Prabhala, P., Michaliková, B., Sommarin, M., Doyle, A., Lang, S., Kanzenbach, K., Tufvesson, E., Lindstedt, S., Leigh, N. D., Karlsson, G., Bjermer, L., Westergren Thorsson, G. & Magnusson, M., 2021, In: American Journal of Respiratory Cell and Molecular Biology. 65, 1, p. 103-113Research output: Contribution to journal › Article › peer-review
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Resolving the Cellular Heterogeneity of Human Hematopoietic Stem and Progenitor Cells. The influence of cellular heterogeneity on ontogeny, ageing and leukemia.
Sommarin, M., 2021, Lund: Lund University, Faculty of Medicine. 82 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile200 Downloads (Pure) -
2020
S100A6 is a critical regulator of hematopoietic stem cells.
Tan Grahn, H. M., Niroula, A., Vegvari, A., Oburoglu, L., Pertesi, M., Warsi, S., Safi, F., Miharada, N., C. Garcia, S., Siva, K., Liu, Y., Rörby, E., Nilsson, B., Zubarev, R. A. & Karlsson, S., 2020 Jun 19, In: Leukemia.Research output: Contribution to journal › Article › peer-review
Open Access -
Loss of Cxcr5 alters neuroblast proliferation and migration in the aged brain
Fritze, J., Ginisty, A., McDonald, R., Quist, E., Stamp, E., Monni, E., Dhapola, P., Lang, S. & Ahlenius, H., 2020, In: Stem Cells. 38, 9, p. 1175-1187Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging
Säwen, P., Eldeeb, M., Erlandsson, E., Kristiansen, T. A., Laterza, C., Kokaia, Z., Karlsson, G., Yuan, J., Soneji, S., Mandal, P. K., Rossi, D. J. & Bryder, D., 2018 Dec 18, In: eLife. 7, e41258.Research output: Contribution to journal › Article › peer-review
Open Access -
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
Bartoschek, M., Oskolkov, N., Bocci, M., Lövrot, J., Larsson, C., Sommarin, M., Madsen, C., Lindgren, D., Pekar, G., Karlsson, G., Ringnér, M., Bergh, J., Björklund, Å. K. & Pietras, K., 2018 Dec 4, In: Nature Communications. 9, 1, 5150.Research output: Contribution to journal › Article › peer-review
Open Access -
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
Sommarin, M. N. E., Warfvinge, R., Safi, F. & Karlsson, G., 2018 Oct 25, In: Journal of visualized experiments : JoVE. 140Research output: Contribution to journal › Article › peer-review
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Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis
Jensen, C. T., Åhsberg, J., Sommarin, M. N. E., Strid, T., Somasundaram, R., Okuyama, K., Ungerbäck, J., Kupari, J., Airaksinen, M. S., Lang, S., Bryder, D., Soneji, S., Karlsson, G. & Sigvardsson, M., 2018 Jul 2, In: Journal of Experimental Medicine. 215, 7, p. 1947-1963 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Don't judge a cell by its cover: heterogeneity within early lymphoid progenitors
Karlsson, G., Sigvardsson, M. & Böiers, C., 2017 Dec 15, In: EMBO Journal. 36, 24, p. 3552-3554 3 p.Research output: Contribution to journal › Article
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The stem cell regulator PEDF is dispensable for maintenance and function of hematopoietic stem cells
Rörby, E., Billing, M., Dahl, M., Warsi, S., Andradottir, S., Miharada, K., Siva, K., Jönsson, J.-I., Blank, U., Karlsson, G. & Karlsson, S., 2017 Aug 31, In: Scientific Reports. 7, 10134.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition
Guibentif, C., Rönn, R. E., Böiers, C., Lang, S., Saxena, S., Soneji, S., Enver, T., Karlsson, G. & Woods, N.-B., 2017 Apr 4, In: Cell Reports. 19, 1, p. 10-19 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML
Warfvinge, R., Geironson Ulfsson, L., Sommarin, M. N. E., Lang, S., Karlsson, C., Roschupkina, T., Stenke, L., Stentoft, J., Olsson-Strömberg, U., Hjorth-Hansen, H., Mustjoki, S., Soneji, S., Richter, J. & Karlsson, G., 2017 Apr, In: Blood. 129, 17, p. 2384-2394Research output: Contribution to journal › Article › peer-review
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2016
Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion
Capellera-Garcia, S., Pulecio, J., Dhulipala, K., Siva, K., Rayon-Estrada, V., Singbrant, S., Sommarin, M. N. E., Walkley, C. R., Soneji, S., Karlsson, G., Raya, Á., Sankaran, V. G. & Flygare, J., 2016 Jun 14, In: Cell Reports. 15, 11, p. 2550-2562 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A network including TGFβ/Smad4, Gata2 and p57 regulates proliferation of mouse hematopoietic progenitor cells.
Billing, M., Rörby, E., May, G., Tipping, A. J., Soneji, S., Brown, J., Salminen, M., Karlsson, G., Enver, T. & Karlsson, S., 2016, In: Experimental Hematology. 44, 5, p. 399-409Research output: Contribution to journal › Article › peer-review
Open AccessFile253 Downloads (Pure) -
2015
SCExV: a webtool for the analysis and visualisation of single cell qRT-PCR data.
Lang, S., Ugale, A., Erlandsson, E., Karlsson, G., Bryder, D. & Soneji, S., 2015, In: BMC Bioinformatics. 16, 320.Research output: Contribution to journal › Article › peer-review
Open AccessFile208 Downloads (Pure)