Systems Immunology

The Consiglio Lab investigates how biological sex impacts human immunity using systems immunology approaches. Generally, females mount more robust immune responses than males, resulting in lower severity of infections, decreased frequency of cancer, but increased prevalence of autoimmunity. Yet, we do not fully understand the precise mechanisms that underlie such sex discrepancies. Our lab combines high throughput multiomics technologies with state-of-the-art computational methods to understand mechanisms of sex differences in human immunity. We do this via two main projects: 1. Immunomonitoring of human cohorts using systems immunology 2. Mechanistic investigation of sex hormone modulation of the human immune system