Research output per year
Research output per year
BMC, C13
221 84 Lund
Sweden
Acute myeloid leukemia (AML) is a fatal disorder of the blood-forming bone marrow cells. In most patients, the cellular origin of AML is thought to be a normal hematopoietic stem cell (HSC) that through a series of genetic lesions gives rise to cells with leukemia-initiating capacity, also termed leukemia stem cells (LSCs), which propagate into frank AML. The major goals of our research is to identify therapeutic targets essential for LSCs, to generate novel insights into LSC biology, and to provide in vivo proof of concept for a therapeutic effect. To this end, we use pooled CRISPR/Cas9-screens and lentiviral barcoding of LSC. We have a translational focus and our research has already resulted in a spin-off company (Cantargia). If successful, our research may translate into new therapeutic opportunities in AML, a disease associated with poor prognosis.
Person
Person
Person
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Popovic, S. (Researcher), Nordenfelt, P. (Supervisor), Järås, M. (Assistant supervisor) & Swaminathan, V. (Assistant supervisor)
2025/02/01 → …
Project: Dissertation
Järås, M. (PI)
2024/01/01 → 2028/12/31
Project: Research
Stanek, P. (Researcher)
2022/06/01 → 2028/06/01
Project: Research
Hagström-Andersson, A. (Organiser), Scheding, S. (Organiser), Stanek, P. (Speaker) & Sandén, C. (Role not specified)
Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Jädert, C. (Organiser), Wihlborg, A.-K. (Invited speaker), Bernardo, C. (Organiser), Richter, C. (Organiser), Madsen, C. (Organiser), Hanahan, D. (Invited speaker), Dahm, Å. (Invited speaker), Ahlgren, G. (Invited speaker), Grönlund, T. (Invited speaker), Bjartell, A. (Invited speaker), Walse, B. (Invited speaker), Paulsson, K. (Session chair), Niméus, E. (Session chair), Buchwald, P. (Session chair), Andersson, R. (Session chair), Järås, M. (Session chair), Carneiro, A. (Session chair), Axelson, H. (Session chair), Sjödahl, G. (Session chair) & Berntsson, P. (Advisor)
Activity: Participating in or organising an event › Organisation of conference
Pereira, C.-F. (First/primary/lead supervisor), Agace, W. (Second supervisor), Ramalho-Santos, J. (Second supervisor), Graf, T. (Commissioned member of Examining committee), Ahlenius, H. (Commissioned member of Examining committee), Järås, M. (Commissioned member of Examining committee), Almeida, L. (Commissioned member of Examining committee), Mano, M. (Commissioned member of Examining committee) & Roelsgaard Jakobsen, M. (Commissioned member of Examining committee)
Activity: Examination and supervision › Supervision of PhD students