Research output per year
Research output per year
Unit profile
Research
Acute myeloid leukemia (AML) is a fatal disorder of the blood-forming bone marrow cells. In most patients, the cellular origin of AML is thought to be a normal hematopoietic stem cell (HSC) that through a series of genetic lesions gives rise to cells with leukemia-initiating capacity, also termed leukemia stem cells (LSCs), which propagate into frank AML. The major goals of our research is to identify therapeutic targets essential for LSCs, to generate novel insights into LSC biology, and to provide in vivo proof of concept for a therapeutic effect. To this end, we use pooled CRISPR/Cas9-screens and lentiviral barcoding of LSC. We have a translational focus and our research has already resulted in a spin-off company (Cantargia). If successful, our research may translate into new therapeutic opportunities in AML, a disease associated with poor prognosis.
Subject classification (UKÄ)
- Cancer and Oncology
- Basic Cancer Research
Free keywords
- Leukemia
- AML
- stem cells
- antibody
- targeted therapy
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Somadri Ghosh
- Targeted therapies in leukemia - Postdoctoral fellow
- LUCC: Lund University Cancer Centre - Researcher
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Biomedical analyst
Person
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Marcus Järås
- Division of Clinical Genetics - Associate professor
- Targeted therapies in leukemia - Research team manager
- LUCC: Lund University Cancer Centre - Principal investigator
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Principal investigator
Person
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Pablo Peña
- Division of Clinical Genetics - Research engineer
- Targeted therapies in leukemia - Research engineer
- LUCC: Lund University Cancer Centre - Research support
Person
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Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment
Hansen, N., Peña-Martínez, P., Skoog, P., Reinbach, K., Hansen, F. C., Faria, S. L., Grönberg, C., Abdilleh, K., Magnusson, S., Von Wachenfeldt, K., Millrud, C. R., Liberg, D. & Järås, M., 2024 Dec, In: Journal for ImmunoTherapy of Cancer. 12, 12, e009523.Research output: Contribution to journal › Article › peer-review
Open Access -
Apolipoprotein A-I priming via SR-BI and ABCA1 receptor binding upregulates mitochondrial metabolism to promote insulin secretion in INS-1E cells
Lyons, C. L., Cowan, E., Nilsson, O., Mohar, M., Peña-Martínez, P., Eliasson, L. & Lagerstedt, J. O., 2024 Nov, In: PLoS ONE. 19, 11 November, e0311039.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases
Thorsson, H., Henningsson, R., Puente-Moncada, N., Peña-Martínez, P., Sjöström, L., Ågerstam, H., Sandén, C., Rissler, M., Castor, A., Marquart, H., Modvig, S., Paulsson, K., Pronk, C. J., Schmiegelow, K., Hyrenius-Wittsten, A., Orsmark-Pietras, C., Lilljebjörn, H. & Fioretos, T., 2024 Sept 26, In: Blood. 144, 13, p. 1399-1411Research output: Contribution to journal › Article › peer-review
Open Access
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Exploring the role of antibody engineering in HER2-targeted cancer immunotherapy
Popovic, S. (Researcher), Nordenfelt, P. (Supervisor), Järås, M. (Assistant supervisor) & Swaminathan, V. (Assistant supervisor)
2025/02/01 → …
Project: Dissertation
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Targeting new innate immune evasion mechanisms in acute myeloid leukemia
Järås, M. (PI)
2024/01/01 → 2028/12/31
Project: Research
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Molecular and computational analyses for improved clinical decision making in acute myeloid leukemia
Stanek, P. (Researcher)
2022/06/01 → 2028/06/01
Project: Research
Activities
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LUCC - Blood, lymphoma & myeloma: "Acute myeloid leukemia - clinical features and patient-based experimental research" - Inaugural session
Hagström-Andersson, A. (Organiser), Scheding, S. (Organiser), Stanek, P. (Speaker) & Sandén, C. (Role not specified)
2021 Jun 3Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Focus on Cancer collaboration
Jädert, C. (Organiser), Wihlborg, A.-K. (Invited speaker), Bernardo, C. (Organiser), Richter, C. (Organiser), Madsen, C. (Organiser), Hanahan, D. (Invited speaker), Dahm, Å. (Invited speaker), Ahlgren, G. (Invited speaker), Grönlund, T. (Invited speaker), Bjartell, A. (Invited speaker), Walse, B. (Invited speaker), Paulsson, K. (Session chair), Niméus, E. (Session chair), Buchwald, P. (Session chair), Andersson, R. (Session chair), Järås, M. (Session chair), Carneiro, A. (Session chair), Axelson, H. (Session chair), Sjödahl, G. (Session chair) & Berntsson, P. (Advisor)
2021 Feb 4Activity: Participating in or organising an event › Organisation of conference
File -
Supervision of PhD student: Fábio Fiúza Rosa
Pereira, C.-F. (First/primary/lead supervisor), Agace, W. (Second supervisor), Ramalho-Santos, J. (Second supervisor), Graf, T. (Commissioned member of Examining committee), Ahlenius, H. (Commissioned member of Examining committee), Järås, M. (Commissioned member of Examining committee), Almeida, L. (Commissioned member of Examining committee), Mano, M. (Commissioned member of Examining committee) & Roelsgaard Jakobsen, M. (Commissioned member of Examining committee)
2018 → 2021Activity: Examination and supervision › Supervision of PhD students