Research output per year
Research output per year
Unit profile
Description
Marcus Järås is Research Group Leader for this research groupResearch
Acute myeloid leukemia (AML) is a fatal disorder of the blood-forming bone marrow cells. In most patients, the cellular origin of AML is thought to be a normal hematopoietic stem cell (HSC) that through a series of genetic lesions gives rise to cells with leukemia-initiating capacity, also termed leukemia stem cells (LSCs), which propagate into frank AML. The major goals of our research is to identify therapeutic targets essential for LSCs, to generate novel insights into LSC biology, and to provide in vivo proof of concept for a therapeutic effect. To this end, we use pooled CRISPR/Cas9-screens and lentiviral barcoding of LSC. We have a translational focus and our research has already resulted in a spin-off company (Cantargia). If successful, our research may translate into new therapeutic opportunities in AML, a disease associated with poor prognosis.UKÄ subject classification
- Cancer and Oncology
Keywords
- Leukemia
- AML
- stem cells
- antibody
- targeted therapy
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Somadri Ghosh
- Targeted therapies in leukemia - Postdoctoral fellow
- LUCC: Lund University Cancer Centre - Postdoc
Person
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Marcus Järås
- Division of Clinical Genetics - Associate professor
- Targeted therapies in leukemia - Research team manager
- LUCC: Lund University Cancer Centre - Principal investigator
Person
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Pablo Peña
- Division of Clinical Genetics - Research engineer
- Targeted therapies in leukemia - Research engineer
- LUCC: Lund University Cancer Centre - Research support
Person
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Modeling Human Hematopoiesis Using the CRISPR/Cas9 System
Bäckström, A., 2023, Lund: Lund University, Faculty of Medicine. 83 p.Research output: Thesis › Doctoral Thesis (compilation)
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Interleukin 4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation
Peña-Martínez, P., Ramakrishnan, R., Högberg, C., Jansson, C., Nord, D. G. & Järås, M., 2022 Apr, In: Haematologica. 107, 4, p. 816-824 9 p.Research output: Contribution to journal › Article › peer-review
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The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML
von Palffy, S., Thorsson, H., Peña-Martínez, P., Puente-Moncada, N., Sandén, C., Blom, A. M., Henningsson, R., Juliusson, G., King, B., Landberg, N., Lazarevic, V. L., Orsmark-Pietras, C., Rissler, M., Rissler, V., Ågerstam, H., Järås, M., Lilljebjörn, H. & Fioretos, T., 2022 Nov 16, (E-pub ahead of print) In: Blood Advances.Research output: Contribution to journal › Article › peer-review
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Molecular and computational analyses for improved clinical decision making in acute myeloid leukemia
2022/06/01 → 2028/06/01
Project: Research
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Defining Regulators of Human Hematopoietic Stem Cells using CRISPR/Cas9 Gene Targeting
Bäckström, A., Larsson, J. & Järås, M.
2018/05/01 → …
Project: Dissertation
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CRISPRideas: Debating CRISPR – Comparative analysis of the discourses on medical and agricultural applications of new genome editing technologies
Broberg, K., Tunlid, A., Järås, M., Vareman, N., Nordberg, A., Jakobsson, J., Hansson, M., Hansson, K., Wahlberg, K. E., Kristoffersson, U. & Dunér, I.
2019/10/01 → 2020/06/30
Project: Network
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Focus on Cancer collaboration
Cecilia Jädert (Organiser), Anna-Karin Wihlborg (Invited speaker), Carina Bernardo (Organiser), Corinna Richter (Organiser), Chris Madsen (Organiser), Douglas Hanahan (Invited speaker), Åsa Dahm (Invited speaker), Göran Ahlgren (Invited speaker), Trine Grönlund (Invited speaker), Anders Bjartell (Invited speaker), Bjorn Walse (Invited speaker), Kajsa Paulsson (Session chair), Emma Niméus (Session chair), Pamela Buchwald (Session chair), Roland Andersson (Session chair), Marcus Järås (Session chair), Ana Carneiro (Session chair), Håkan Axelson (Session chair), Gottfrid Sjödahl (Session chair) & Pia Berntsson (Advisor)
2021 Feb 4Activity: Participating in or organising an event › Organisation of conference
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Supervision of PhD student: Fábio Fiúza Rosa
Carlos-Filipe Pereira (First/primary/lead supervisor), William Agace (Second supervisor), João Ramalho-Santos (Second supervisor), Thomas Graf (Commissioned member of Examining committee), Henrik Ahlenius (Commissioned member of Examining committee), Marcus Järås (Commissioned member of Examining committee), Luis Almeida (Commissioned member of Examining committee), Miguel Mano (Commissioned member of Examining committee) & Martin Roelsgaard Jakobsen (Commissioned member of Examining committee)
2018 → 2021Activity: Examination and supervision › Supervision of PhD students