The Liquid Biopsy and Tumor Progression in Breast Cancer

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Unit profile


Metastatic breast cancer is a major cause of death in middle-aged women. The aim of our research is studying the two routes of metastatic spread; lymphatic and haematogenous, and characterization of disseminated tumor cells in relation to patients’ outcome in clinical cohorts. Even synchronous lymph node metastases show signs of tumor progression compared to the primary tumor with implication on the individual patient’s prognosis. The evolution of the tumor is even more evident in established distant metastases and in circulating tumor cells (CTCs) in the peripheral blood. In the CTC-MBC clinical trial (Clinical Trials NCT01322893) patients with metastatic breast cancer are included and serial blood samples for enumeration and molecular characterization of CTCs using CellSearch® are collected, and serum and plasma from the same time-points are analyzed, referred to as “liquid biopsies”. A downstream method characterizing CTCs then enables real-time analysis of predictive markers.

UKÄ subject classification

  • Cancer and Oncology

Free keywords

  • Breast cancer
  • Circulating tumor cells
  • Prognostic factors

Collaborations and top research areas from the last five years

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  • 13th Medicon Valley Alliance Oncology Network Meeting

    Anette Steenberg (Host), Sophia Zackrisson (Chair), Lisa Ryden (Invited speaker), Mef Nilbert (Invited speaker), Ramin Massoumi (Invited speaker), Sowndarya Muthukumar (Invited speaker), Erik Söderbäck (Invited speaker), Cecilia Jädert (Member of programme committee) & Pia Berntsson (Advisor)

    2023 Jan 23

    Activity: Participating in or organising an eventOrganisation of conference

  • World Cancer Day 2020

    Susanne Dieroff Hay (Member of programme committee), Björn Ohlsson (Member of programme committee), Lisa Rydén (Member of programme committee), Mats Jerkeman (Member of programme committee), Karin Leandersson (Member of programme committee), Leena Liljedahl (Member of programme committee), Pia Berntsson (Member of programme committee), Kristian Pietras (Speaker), Lisa Ryden (Speaker), Björn ohlsson (Speaker), Mats Jerkeman (Speaker), Ulf Malmqvist (Speaker), Pia Dellson (Speaker) & Maria Bjerstam (Speaker)

    2020 Feb 4

    Activity: Participating in or organising an eventOrganisation of conference