Research output per year
Research output per year
BMC, C13
221 84 Lund
Sweden
My research efforts focus on understanding the pathogenesis of infant and non-infant pediatric leukemia with MLL-gene rearrangements. Infant leukemia is defined by an exceedingly poor prognosis and there is a need for new therapeutic options. We use high-resolution genomic methods to study the landscape of epigenetic and genetic lesions that underlie MLL-R leukemia at diagnosis and at relapse. Pertinent lesions are studies further in murine models to unravel their impact on tumor behavior. These studies will enhance our understanding of the differences between infant and non-infant MLL-R leukemia, and the nature of alterations that drive its development, and will increase our understanding about the genetic basis of relapse. In addition, we are interested in defining how distinct tumor clones cooperate to drive the growth of MLL-R leukemia, and the mechanisms behind clonal cooperation using murine models and in vitro assays to determine its biological significance.
Person
Person
Person
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
The Swedish Childhood Cancer Fund
2025/01/01 → 2027/12/31
Project: Research
2024/01/01 → 2027/12/15
Project: Research
The Swedish Childhood Cancer Fund, Crafoord Foundation, Mats Paulssons stiftelse
2023/06/01 → 2027/05/31
Project: Research
Berntsson, P. (Organiser), Jerkeman, M. (Chair), Järås, M. (Chair), Trägårdh, E. (Speaker), Hagström-Andersson, A. (Speaker), Hyrenius Wittsten, A. (Speaker) & Nilsson, M. (Speaker)
Activity: Participating in or organising an event › Organisation of conference