Red blood cells constitute 85% of all body cells. Our research is focused on those polymorphic red cell surface molecules called blood groups. We identify novel blood groups, and their genetic bases. Interactions with other molecules, cells and pathogens are unraveled to clarify blood group function in health and disease. We also aim to increase compatibility of blood transfusion, transplantation and pregnancy – conditions when blood groups play a major role for successful outcomes. Every year, close to half a million blood units from blood donors support Swedish healthcare and tools for DNA-based blood grouping have been introduced in clinical practice to extend matching for increased transfusion safety. We have also revealed blood groups providing protection against infection with HIV or malaria in vitro. Currently, our three main research themes are:
I. Blood group discovery
II. Host-pathogen interactions involving blood groups
III. The role of red cells in hemostasis