Urothelial Cancer Genomics

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Unit profile

Urothelial cancer, bladder cancer, is divided in two major subtypes, non-muscle invasive and muscle-invasive, with very distinct biological and clinical properties. Prognosis and treatment are mainly based on pathological criteria. The fact that only 20-25% of high grade low stage tumors are confirmed by review pathology, and that 30% of patients with intermediate stage tumors are upstaged after repeated transurethral resection (TUR), argues that standard pathological methods is unreliable for proper tumor assessment. To address these problems we have constructed a molecular taxonomy of urothelial cancer. This taxonomy is based on a combination of gene expression, epigenetic and genomic changes, and gene mutations analyses. The overall goal is to refine and optimize UC classification into molecular subtypes important for prognosis and treatment.

UKÄ subject classification

  • Cancer and Oncology


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