Åke Borg

Expert

Personal profile

Research

Breast cancer is the major malignant disease in women and has a continuously rising incidence. It is a remarkably heterogeneous disease in respect of genetic predisposition, tumor biology and clinical course. Better biomarkers are needed to improve diagnosis, prognostication and treatment prediction, to allow use of more precise drugs and avoid overtreatment. New sequencing technology provides thorough characterization of the genome and transcriptome. Breast tumors can be classified into subtypes based on patterns of gene expression, DNA methylation, nucleotide substitutions and genomic rearrangements. Pathogenic germline sequence variants in two major susceptibility genes BRCA1 and BRCA2 confer a high relative risk and explain a proportion of familial breast cancer. Few other high-risk genes are known and current knowledge supports a polygenic model, a role of common low-risk variants that may interact in multiplicative fashion, but also of rare intermediate-risk gene variants. Modern medicine relies on successful translation of new molecular research findings into the clinic, a critical step that is facilitated by forming networks and close interactions between scientists and clinicians.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Cancer and Oncology

Free keywords

  • Breast cancer
  • Inherited predisposition
  • Tumor genomics

Collaborations the last five years

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