Research output per year
Research output per year
Professor, consultant
My research is focused on understanding the underlying pathogenic mechanisms of the neurodegenerative and neuropsychiatric Huntington disease (HD) with the ultimate aim to develop effective therapies. HD is a devastating disorder always caused by an expanded CAG triplet repeat mutation in the huntingtin gene. Importantly, individuals with the mutant HD gene suffer from psychiatric symptoms and metabolic dysfunction many years before onset of typical motor symptoms. My hypothesis is that the non-motor features are due to hypothalamic pathology. In my research group, we have shown that hypothalamic changes occur early in clinical HD using both MRI and postmortem analyses. We have established a casual relationship between hypothalamic huntingtin and the development of metabolic and psychiatric disturbances in mice. Ongoing work will identify key molecular pathways and the critical neuronal circuitries affected early in the HD hypothalamus in order to develop disease modifying treatments.
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Working paper/Preprint › Preprint (in preprint archive)
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Lundin, S., Torkelson, E., Hagen, N., Petersen, M., Kirik, D. & Petersén, Å.
Project: Research
Paulina Pettersson (Organiser), Anders Björklund (Member of programme committee), Christine Ekdahl Clementson (Member of programme committee), Martin Garwicz (Member of programme committee), Måns Magnusson (Member of programme committee), Bo Norrving (Member of programme committee), Malin Parmar (Member of programme committee), Åsa Petersén (Member of programme committee), Oskar Hansson (Member of programme committee), MARIA COMPAGNO STRANDBERG (Member of programme committee), Ulrik Gether (Invited speaker), Andreas Nieder (Invited speaker), Gonçalo Castelo-Branco (Invited speaker), Angela Cenci Nilsson (Chair), Johan Jakobsson (Chair), Silvia Cappello (Invited speaker), Eero Castrén (Keynote/plenary speaker), Raquel Garza (Presenter), Alison Salvador (Presenter), Alrik Schörling (Presenter), Anita Adami (Presenter), Fredrik Nilsson (Presenter), Alessandro Fiorenzano (Presenter), Chandramouli Muralidharan (Presenter), Ofelia Karlsson (Presenter), Ninoslav Pandiloski (Presenter), Edoardo Sozzi (Presenter) & Petter Storm (Presenter)
Activity: Participating in or organising an event › Organisation of conference
Malin Parmar (Organiser), Martin Garwicz (Organiser), Anders Björklund (Organiser), Christine Ekdahl Clementson (Organiser), Bo Norrving (Member of programme committee), Åsa Petersén (Organiser), Oskar Hansson (Member of programme committee), MARIA COMPAGNO STRANDBERG (Member of programme committee), Paulina Pettersson (Organiser), Claire Wyart (Invited speaker), Markus Heilig (Invited speaker), Marie Carlen (Invited speaker), Ana Gonzalez Ramos (Presenter), Elna Dickson (Presenter), Emelie Andersson (Presenter), Kajsa Brolin (Presenter), Martino Avallone (Presenter), Nicholas Bechet (Presenter), Michael Ewers (Invited speaker), Magdalena Götz (Keynote/plenary speaker) & Daniella Ottosson (Chair)
Activity: Participating in or organising an event › Organisation of conference
Paulina Pettersson (Organiser), Anders Björklund (Member of programme committee), Christine Ekdahl Clementson (Member of programme committee), Martin Garwicz (Member of programme committee), Måns Magnusson (Member of programme committee), Bo Norrving (Member of programme committee), Malin Parmar (Member of programme committee), Åsa Petersén (Member of programme committee), Oskar Hansson (Member of programme committee), MARIA COMPAGNO STRANDBERG (Member of programme committee), Marcella Birtele (Presenter), Ella Quist (Presenter), Alexander Lind (Presenter), Jonas Fritze (Presenter), Laura Andreoli (Presenter) & Sara Nolbrant (Presenter)
Activity: Participating in or organising an event › Participation in conference
Paulina Pettersson (Organiser), Anders Björklund (Member of programme committee), Christine Ekdahl Clementson (Member of programme committee), Martin Garwicz (Member of programme committee), Måns Magnusson (Member of programme committee), Bo Norrving (Member of programme committee), Malin Parmar (Member of programme committee) & Åsa Petersén (Member of programme committee)
Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
Paulina Pettersson (Organiser), Anders Björklund (Member of programme committee), Christine Ekdahl Clementson (Member of programme committee), Martin Garwicz (Member of programme committee), Måns Magnusson (Member of programme committee), Bo Norrving (Member of programme committee), Malin Parmar (Member of programme committee), Åsa Petersén (Member of programme committee), Nedjeljka Ivica (Presenter), Una Avdic (Presenter), Jakob Hakon Christensen (Presenter), Per Brattås (Presenter), Tiago Cardoso (Presenter) & Maria João Miranda Pereira (Presenter)
Activity: Participating in or organising an event › Participation in conference