Personal profile
Research
Dr. Alessandro Fiorenzano holds a post-doctoral position at the Department of Developmental and Regenerative Neurobiology, Lund University (Sweden), where he is working with Prof. Malin Parmar’s group. Originally from Italy, Alessandro was awarded his Bachelor's and Master's degrees in Biology from the University of Naples Federico II. He obtained his PhD in Molecular and Cellular Biotechnology at the Italian National Research Council Institute of Genetics and Biophysics, where he consolidated his background in stem cell biology. During his PhD program, he studied the impact of the extracellular microenvironment on pluripotency and differentiation of embryonic stem cells (ESCs), with particular emphasis on extrinsic and intrinsic pathways including ESC self-renewal regulation by non-coding RNAs. His current focus is on investigating the molecular mechanisms underlying neuronal specification that efficiently drive controlled differentiation of human stem cells into subtype-specific dopamine neurons for use in stem cell-based therapies for brain repair in Parkinson’s disease.
Subject classification (UKÄ)
- Medical and Health Sciences
- Basic Medicine
- Neurosciences
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
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Non-cell-autonomous control of mouse gastruloid development by the ultra-conserved lncRNA T-UCstem1
Coppola, A., Amoroso, F., Saracino, F., Andolfi, G., Sozzi, E., Salerno, P., Zoppoli, P., Fiorenzano, A., Merla, G., Patriarca, E. J., Minchiotti, G. & Fico, A., 2025 Dec 15, In: EMBO Journal. 44, 24, p. 7620-7648 29 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Protocol for isolating nuclei from human stem cell-derived grafts for single-nucleus RNA sequencing
Sozzi, E., Storm, P. & Fiorenzano, A., 2025 Dec, In: STAR Protocols. 6, 4, 104197.Research output: Contribution to journal › Article › peer-review
Open Access -
Advances, challenges, and opportunities of human midbrain organoids for modelling of the dopaminergic system
Fiorenzano, A., Sozzi, E., Kastli, R., Iazzetta, M. R., Bruzelius, A., Arlotta, P. & Parmar, M., 2025 Aug 1, In: EMBO Journal. 44, 15, p. 4181-4195 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Three-dimensional cell-cell interactions promote direct reprogramming of patient fibroblasts into functional and transplantable neurons
Kajtez, J., Laurin, K., Nilsson, F., Bruzelius, A., Cepeda-Prado, E., Birtele, M., Barker, R. A., Herborg, F., Ottosson, D. R., Storm, P., Fiorenzano, A., Habekost, M. & Parmar, M., 2025 Jun 6, In: Science Advances. 11, 23, eadq7855.Research output: Contribution to journal › Article › peer-review
Open Access -
Editorial: Decoding complexity: genomic, epigenomic, and environmental dynamics in developmental and neurogenetic disorders
Fiorenzano, A. & Azevedo, L., 2025, In: Frontiers in Genetics. 16, 1724013.Research output: Contribution to journal › Debate/Note/Editorial
Open Access
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Mapping human dopamine neuron diversity at single-cell resolution for enhanced stem cell therapy in Parkinson's Disease
Fiorenzano, A. (PI)
2023/01/01 → 2027/12/31
Project: Research
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Unravelling the molecular basis of sporadic Parkinson's disease in human brain organoids
Fiorenzano, A. (PI)
2024/05/27 → 2025/05/27
Project: Research
Activities
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Neuroscience Day 2022
Pettersson, P. (Organiser), Björklund, A. (Member of programme committee), Ekdahl Clementson, C. (Member of programme committee), Garwicz, M. (Member of programme committee), Magnusson, M. (Member of programme committee), Norrving, B. (Member of programme committee), Parmar, M. (Member of programme committee), Petersén, Å. (Member of programme committee), Hansson, O. (Member of programme committee), COMPAGNO STRANDBERG, M. (Member of programme committee), Gether, U. (Invited speaker), Nieder, A. (Invited speaker), Castelo-Branco, G. (Invited speaker), Cenci Nilsson, A. (Chair), Jakobsson, J. (Chair), Cappello , S. (Invited speaker), Castrén, E. (Keynote/plenary speaker), Garza, R. (Presenter), Salvador, A. (Presenter), Schörling, A. (Presenter), Adami, A. (Presenter), Nilsson, F. (Presenter), Fiorenzano, A. (Presenter), Muralidharan, C. (Presenter), Karlsson, O. (Presenter), Pandiloski, N. (Presenter), Sozzi, E. (Presenter) & Storm, P. (Presenter)
2022 May 5Activity: Participating in or organising an event › Organisation of conference
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Unistem Day 2020
Karlsson, G. (Organiser), Karlsson, C. (Organiser), Pettersson, P. (Organiser), McKay, C. (Organiser), Ahlenius, H. (Organiser), Parmar, M. (Organiser), Magnusson, M. (Organiser), Warfvinge, R. (Organiser), Nolbrant, S. (Speaker), Johansson, P. (Contributor), Atacho, D. (Contributor), Shrigley, S. (Contributor), Jarl, U. (Contributor), Sparrenius, M. (Contributor), Mattsson, B. (Contributor), Hoban, D. (Contributor), Fiorenzano, A. (Contributor), Giacomoni, J. (Contributor), Nilsson, F. (Contributor), Sozzi, E. (Contributor), Hammarberg, A. (Contributor), Pircs, K. (Contributor), Bruzelius, A. (Contributor), Birtele, M. (Contributor), Kidnapillai, S. (Contributor), Cepeda-Prado, E. (Contributor), Mikulik, K. (Contributor), Garza, R. (Contributor) & Storm, P. (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Supervision of PhD student: Edoardo Sozzi
Parmar, M. (First/primary/lead supervisor), Ottosson, D. (Joint second supervisor) & Fiorenzano, A. (Joint second supervisor)
2020 → …Activity: Examination and supervision › Supervision of PhD students
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Unistem Day 2019
Parmar, M. (Organiser), Pettersson, P. (Organiser), Shrigley, S. (Contributor), Adler, A. (Contributor), Hoban, D. (Contributor), Sparrenius, M. (Contributor), Fiorenzano, A. (Contributor), Giacomoni, J. (Contributor), Zhang, Y. (Contributor), Grassi, D. (Contributor), Garza, R. (Contributor), Pircs, K. (Contributor), Nolbrant, S. (Contributor), Nilsson, F. (Contributor), Ottosson, D. (Contributor), Birtele, M. (Contributor), Johansson, P. (Contributor), Atacho, D. (Contributor), Jarl, U. (Contributor), Mattsson, B. (Contributor) & Hammarberg, A. (Contributor)
2019 Mar 15Activity: Participating in or organising an event › Organisation of public lecture/debate/seminar