Alex Evilevitch

2023

Temperature-induced DNA density transition in phage λ capsid revealed with contrast-matching SANS

Villanueva Valencia, J. R., Tsimtsirakis, E., Krueger, S. & Evilevitch, A., 2023 Nov 7, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 45, e2220518120.

Research output: Contribution to journal › Article › peer-review

‘SAXS-osmometer’ method provides measurement of DNA pressure in viral capsids and delivers an empirical equation of state

Villanueva-Valencia, J. R., Li, D., Casjens, S. R. & Evilevitch, A., 2023 Oct 27, In: Nucleic Acids Research. 51, 21, p. 11415-11427

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Reconstituted virus-nucleus system reveals mechanics of herpesvirus genome uncoating

Evilevitch, A. & Tsimtsirakis, E., 2022 Dec 20, In: QRB Discovery. 3, e2.

Research output: Contribution to journal › Article › peer-review

Open Access

Intranuclear HSV-1 DNA ejection induces major mechanical transformations suggesting mechanoprotection of nucleus integrity

Evilevitch, A. & Hohlbauch, S. V., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, p. 1-12 e2114121119.

Research output: Contribution to journal › Article › peer-review

Open Access

Mechanical Capsid Maturation Facilitates the Resolution of Conflicting Requirements for Herpesvirus Assembly

Evilevitch, A. & Sae-Ueng, U., 2022, In: Journal of Virology. 96, 4, p. 1-13 e01831-21.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Energetics of the DNA-Filled Head

Evilevitch, A., 2021, Reference Module in Life Sciences. Elsevier, Vol. 4. p. 1-8

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Role of hsv-1 capsid vertex-specific component (Cvsc) and viral terminal dna in capsid docking at the nuclear pore

Villanueva-Valencia, J. R., Tsimtsirakis, E. & Evilevitch, A., 2021, In: Viruses. 13, 12, 2515.

Research output: Contribution to journal › Article › peer-review

Open Access

UL25 capsid binding facilitates mechanical maturation of the Herpesvirus capsid and allows retention of pressurized DNA

Freeman, K. G., Huffman, J. B., Homa, F. L. & Evilevitch, A., 2021, In: Journal of Virology. 95, 20, e00755-21.

Research output: Contribution to journal › Article › peer-review

2020

Nanoscale Structural Characterization of Individual Viral Particles Using Atomic Force Microscope Infrared (AFM-IR) and Tip-Enhanced Raman Spectroscopy (TERS)

Dou, T., Li, Z., Zhang, J., Evilevitch, A. & Kurouski, D., 2020, In: Analytical Chemistry. 92, 16, p. 11297–11304

Research output: Contribution to journal › Article › peer-review

Pressurized DNA state inside herpes capsids-A novel antiviral target

Brandariz-Nuñez, A., Robinson, S. J. & Evilevitch, A., 2020, In: PLoS Pathogens. 16, 7, e1008604.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection

Brandariz-Nuñez, A., Liu, T., Du, T. & Evilevitch, A., 2019 Aug 8, In: eLife. 8, e47212.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

The mobility of packaged phage genome controls ejection dynamics

Evilevitch, A., 2018 Sept 4, In: eLife. 7, e37345.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Portal Stability Controls Dynamics of DNA Ejection from Phage

Freeman, K. G., Behrens, M. A., Streletzky, K. A., Olsson, U. & Evilevitch, A., 2016 Jul 7, In: Journal of Physical Chemistry B. 120, 26, p. 6421-6429 9 p.

Research output: Contribution to journal › Article › peer-review

2015

Exploring the balance between DNA pressure and capsid stability in Herpes and phage.

Bauer, D. W., Li, D., Huffman, J., Homa, F. L., Wilson, K., Leavitt, J. C., Casjens, S. R., Baines, J. & Evilevitch, A., 2015, In: Journal of Virology. 89, 18, p. 9288-9298

Research output: Contribution to journal › Article › peer-review

Influence of Internal DNA Pressure on Stability and Infectivity of Phage λ.

Bauer, D. W. & Evilevitch, A., 2015, In: Journal of Molecular Biology. 427, 20, p. 3189-3200

Research output: Contribution to journal › Article › peer-review

Ionic switch controls the DNA state in phage λ.

Li, D., Liu, T., Zuo, X., Li, T., Qiu, X. & Evilevitch, A., 2015, In: Nucleic Acids Research. 43, 13, p. 6348-6358

Research output: Contribution to journal › Article › peer-review

Open Access

2014

Major capsid reinforcement by a minor protein in herpesviruses and phage.

Sae-Ueng, U., Liu, T., Catalano, C. E., Huffman, J. B., Homa, F. L. & Evilevitch, A., 2014, In: Nucleic Acids Research. 42, 14, p. 9096-9107

Research output: Contribution to journal › Article › peer-review

Open Access

Solid-to-fluid DNA transition inside HSV-1 capsid close to the temperature of infection.

Sae-Ueng, U., Li, D., Zuo, X., Huffman, J. B., Homa, F. L., Rau, D. & Evilevitch, A., 2014, In: Nature Chemical Biology. 10, 10, p. 861

Research output: Contribution to journal › Article › peer-review

Solid-to-fluid-like DNA transition in viruses facilitates infection.

Liu, T., Sae-Ueng, U., Li, D., Lander, G. C., Zuo, X., Jönsson, B., Rau, D., Shefer, I. & Evilevitch, A., 2014, In: Proceedings of the National Academy of Sciences. 111, 41, p. 14675-14680

Research output: Contribution to journal › Article › peer-review

2013

Photocatalytic Degradation of Bacteriophages Evidenced by Atomic Force Microscopy

Soylemez, E., de Boer, M. P., Sae-Ueng, U., Evilevitch, A., Stewart, T. A. & Nyman, M., 2013 Jan 3, In: PLoS ONE. 8, 1, e53601.

Research output: Contribution to journal › Article › peer-review

Open Access

DNA bending-induced phase transition of encapsidated genome in phage λ

Lander, G. C., Johnson, J. E., Rau, D. C., Potter, C. S., Carragher, B. & Evilevitch, A., 2013, In: Nucleic Acids Research. 41, 8, p. 4518

Research output: Contribution to journal › Article › peer-review

Open Access

Herpes Virus Genome, The Pressure Is On

Bauer, D. W., Huffman, J. B., Homa, F. L. & Evilevitch, A., 2013, In: Journal of the American Chemical Society. 135, 30, p. 11216-11221

Research output: Contribution to journal › Article › peer-review

Modeling and simulation of the mechanical response from nanoindentation test of DNA-filled viral capsids

Ahadi, A., Johansson, D. & Evilevitch, A., 2013, In: Journal of Biological Physics. 39, 2, p. 183-199

Research output: Contribution to journal › Article › peer-review

Physical evolution of pressure-driven viral infection.

Evilevitch, A., 2013, In: Biophysical Journal. 104, 10, p. 2113-2114

Research output: Contribution to journal › Debate/Note/Editorial › peer-review

2012

Challenging Packaging Limits and Infectivity of Phage λ

Nurmemmedov, E., Castelnovo, M., Medina, E., Catalano, C. E. & Evilevitch, A., 2012, In: Journal of Molecular Biology. 415, 2, p. 263-273

Research output: Contribution to journal › Article › peer-review

Chemical mapping of DNA and counter-ion content inside phage by energy-filtered TEM

Nevsten, P., Evilevitch, A. & Wallenberg, R., 2012, In: Journal of Biological Physics. 38, 2, p. 229-240

Research output: Contribution to journal › Article › peer-review

2011

Effects of Salts on Internal DNA Pressure and Mechanical Properties of Phage Capsids.

Evilevitch, A., Roos, W. H., Ivanovska, I. L., Jeembaeva, M., Jönsson, B. & Wuite, G. J. L., 2011, In: Journal of Molecular Biology. 405, p. 18-23

Research output: Contribution to journal › Article › peer-review

Temperature Induced Phase Transition of Encapsidated Phage DNA

Jeembaeva, M., Sae-Ueng, U., Nurmemmedov, E., Castelnovo, M., Jönsson, B. & Evilevitch, A., 2011, (Unpublished).

Research output: Working paper/Preprint › Working paper

2010

DNA Heats Up: Energetics of Genome Ejection from Phage Revealed by Isothermal Titration Calorimetry.

Jeembaeva, M., Jönsson, B., Castelnovo, M. & Evilevitch, A., 2010, In: Journal of Molecular Biology. 395, 5, p. 1079-1087

Research output: Contribution to journal › Article › peer-review

Physics of viral infectivity: Matching genome length with capsid size

Evilevitch, A. & Castelnovo, M., 2010, Emerging Topics in Physical Virology. Stockley, P. G. & Twarock, R. (eds.). Imperial College Press, p. 217-253

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2009

Influence of Internal Capsid Pressure on Viral Infection by Phage lambda

Koester, S., Evilevitch, A., Jeembaeva, M. & Weitz, D. A., 2009, In: Biophysical Journal. 97, 6, p. 1525-1529

Research output: Contribution to journal › Article › peer-review

Three-Dimensional Simulation of Nanoindentation Response of Viral Capsids. Shape and Size Effects

Ahadi, A., Colomo, J. & Evilevitch, A., 2009, In: The Journal of Physical Chemistry Part B. 113, 11, p. 3370-3378

Research output: Contribution to journal › Article › peer-review

2008

Bacteriophage lambda stabilization by auxiliary protein gpD: Timing, location, and mechanism of attachment determined by cryo-EM

Lander, G. C., Evilevitch, A., Jeembaeva, M., Potter, C. S., Carragher, B. & Johnson, J. E., 2008, In: Structure. 16, 9, p. 1399-1406

Research output: Contribution to journal › Article › peer-review

Effects of salt concentrations and bending energy on the extent of ejection of phage genomes

Evilevitch, A., Fang, L. T., Yoffe, A., Castelnovo, M., Rau, D. C., Parsegian, V. A., Gelbart, W. M. & Knobler, C. M., 2008, In: Biophysical Journal. 94, 3, p. 1110-1120

Research output: Contribution to journal › Article › peer-review