Anders Kvist

Search results

• 2023

  Molecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study

  Nacer, D. F., Vallon-Christersson, J., Nordborg, N., Ehrencrona, H., Kvist, A., Borg, Å. & Staaf, J., 2023 Apr 14, In: Genome Medicine. 15, p. 1-20 25.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Observational Studies 100%
  • Breast Neoplasms 82%
  • Population 50%
  • Triple Negative Breast Neoplasms 23%
  • Neoplasms 19%
• 2022

  Breast cancer risks associated with missense variants in breast cancer susceptibility genes

  Dorling, L., Kvist, A., Investigators, KC., Investigators, SGBCC., Easton, D. F., et al., NBCS Collaborators, KConFab Investigators & SGBCC Investigators, 2022, In: Genome Medicine. 14, 1, 51.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Genes 100%
  • Breast Neoplasms 58%
  • Protein Domains 20%
  • Computer Simulation 19%
  • Logistic Models 13%

• Intra-Patient Evolution of HIV-2 Molecular Properties

  Palm, A. A., Esbjörnsson, J., Kvist, A., Månsson, F., Biague, A., Norrgren, H., Jansson, M. & Medstrand, P., 2022 Nov, In: Viruses. 14, 11, 2447.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HIV-2 100%
  • Molecular Evolution 49%
  • Disease Progression 30%
  • Glycosylation 19%
  • HIV-1 16%

• Pathology of tumors associated with pathogenic germline variants in 9 breast cancer susceptibility genes

  Mavaddat, N., Kvist, A., Easton, D. F. & Breast Cancer Association Consortium , 2022, In: JAMA Oncology. 8, 3

  Research output: Contribution to journal › Article › peer-review
• 2021

  Breast cancer risk genes - Association analysis in more than 113,000 women

  Dorling, L., Valcich, J., Li, M., Törngren, T., Borg, Å., Kvist, A. & Easton, D. F., 2021, In: New England Journal of Medicine. 384, 5, p. 428-439 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Precision oncology of high-grade ovarian cancer defined through targeted sequencing

  Wessman, S., Fuentes, B. B., Törngren, T., Kvist, A., Kokaraki, G., Menkens, H., Hjerpe, E., Hugo, Y., Petta, T. B., Borg, Å. & Carlson, J. W., 2021 Oct 1, In: Cancers. 13, 20, 5240.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovarian Neoplasms 100%
  • Poly(ADP-ribose) Polymerase Inhibitors 58%
  • Ovarian Epithelial Carcinoma 50%
  • Carcinoma 43%
  • Mutation 36%

• Prevalence of germline pathogenic variants in 22 cancer susceptibility genes in Swedish pediatric cancer patients

  von Stedingk, K., Stjernfelt, K. J., Kvist, A., Wahlström, C., Kristoffersson, U., Stenmark-Askmalm, M., Wiebe, T., Hjorth, L., Koster, J., Olsson, H. & Øra, I., 2021, In: Scientific Reports. 11, 1, 5307.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Genes 100%
  • Pediatrics 59%
  • Neoplasms 29%
  • Dominant Genes 25%
  • Incidence 17%
• 2020

  Cancer risks associated with germline PALB2 pathogenic variants: An international study of 524 families

  Yang, X., Leslie, G., Doroszuk, A., Schneider, S., Allen, J., Decker, B., Dunning, A. M., Redman, J., Scarth, J., Plaskocinska, I., Luccarini, C., Shah, M., Pooley, K., Dorling, L., Leei, A., Adank, M. A., Adlard, J., Aittomäki, K., Andrulis, I. L., Ang, P., & 99 othersBarwell, J., Bernstein, J. L., Bobolis, K., Borg, Å., Blomqvist, C., Claes, K. B. M., Concannon, P., Cuggia, A., Culver, J. O., Damiola, F., De Pauw, A., Diez, O., Dolinsky, J. S., Domchek, S. M., Engel, C., Evans, D. G., Fostira, F., Garber, J., Golmard, L., Goode, E. L., Gruber, S. B., Hahnen, E., Hake, C., Heikkinen, T., Hurley, J. E., Janavicius, R., Kleibl, Z., Kleiblova, P., Konstantopoulou, I., Kvist, A., Laduca, H., Lee, A. S. G., Lesueur, F., Maher, E. R., Mannermaa, A., Manoukian, S., McFarland, R., McKinnon, W., Meindl, A., Metcalfe, K., Taib, N. A. M., Moilanen, J., Nathanson, K. L., Neuhausen, S., Ng, P. S., Nguyen-Dumont, T., Nielsen, S. M., Obermair, F., Offit, K., Olopade, O. I., Ottini, L., Penkert, J., Pylkäs, K., Goldgar, D., Ramus, S. J., Rudaitis, V., Side, L., Silva-Smith, R., Silvestri, V., Skytte, A. B., Slavin, T., Soukupova, J., Tondini, C., Trainer, A. H., Unzeitig, G., Usha, L., Van Overeem Hansen, T., Whitworth, J., Wood, M., Yip, C. H., Yoon, S. Y., Yussuf, A., Zogopoulos, G., Radice, P., Hopper, J. L., Chenevix-Trench, G., Pharoah, P., George, S. H. L., Balmaña, J., Houdayer, C., James, P., El-Haffaf, Z., Ehrencrona, H., Janatova, M., Peterlongo, P., Nevanlinna, H., Schmutzler, R., Teo, S. H., Robson, M., Pal, T., Couch, F., Weitzel, J. N., Elliott, A., Southey, M., Winqvist, R., Easton, D. F., Foulkes, W. D., Antoniou, A. C. & Tischkowitz, M., 2020 Mar 1, In: Journal of Clinical Oncology. 38, 7, p. 674-685

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Male Breast Neoplasms 100%
  • Breast Neoplasms 78%
  • Neoplasms 56%
  • Ovarian Neoplasms 47%
  • Pancreatic Neoplasms 33%

• Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers

  Glodzik, D., Bosch, A., Hartman, J., Aine, M., Vallon-Christersson, J., Reuterswärd, C., Karlsson, A., Mitra, S., Niméus, E., Holm, K., Häkkinen, J., Hegardt, C., Saal, L. H., Larsson, C., Malmberg, M., Rydén, L., Ehinger, A., Loman, N., Kvist, A., Ehrencrona, H., & 3 othersNik-zainal, S., Borg, Å. & Staaf, J., 2020, In: Nature Communications. 11, 1, 3747.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Adjuvant 74%
  • Triple Negative Breast Neoplasms 72%
  • breast 63%
  • cancer 56%

• Multiplex profiling of serum proteins in solution using barcoded antibody fragments and next generation sequencing

  Brofelth, M., Ekstrand, A. I., Gour, S., Jansson, R., Hedhammar, M., Elleby, B., Kvist, A., Wingren, C., Axelsson, U. & Borrebaeck, C. A. K., 2020, In: Communications Biology. 3, 1, 339.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunoglobulin Fragments 100%
  • High-Throughput Nucleotide Sequencing 75%
  • blood proteins 72%
  • Blood Proteins 69%
  • pancreatic neoplasms 63%

• Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D

  Yang, X., Ehrencrona, H., Borg, Å., Kvist, A., Antoniou, A. C. & et al., 2020, In: Journal of the National Cancer Institute. 112, 12, p. 1242-1250 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovarian Neoplasms 100%
  • Breast Neoplasms 70%
  • Carcinoma 48%
  • Confidence Intervals 43%
  • Inheritance Patterns 11%

• Whole-genome sequencing of triple negative breast cancers in a standard population-based clinical setting

  Staaf, J., Glodzik, D., Bosch Campos, A., Vallon-Christersson, J., Reuterswärd, C., Häkkinen, J., Degasperi, A., Amarante, T. D., Saal, L., Hegardt, C., Stobart, H., Ehinger, A., Larsson, C., Ryden, L., Loman, N., Malmberg, M., Kvist, A., Ehrencrona, H., Davies, H. R., Borg, Å., & 1 othersNik-Zainal, S., 2020 Feb 6, In: Breast Cancer Research and Treatment. 180, p. 531-532

  Research output: Contribution to journal › Published meeting abstract
• 2019

  Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report

  Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., Martins, A., Vaur, D., Goardon, N., Davy, G., Garre, P., García-Barberán, V., Llovet, P., Pérez-Segura, P., Díaz-Rubio, E., Caldés, T., Hruska, K. S., Hsuan, V., Wu, S., Pesaran, T., & 14 othersKaram, R., Vallon-Christersson, J., Borg, A., Investigators, K., Valenzuela-Palomo, A., Velasco, E. A., Southey, M., Vreeswijk, M. P. G., Devilee, P., Kvist, A., Spurdle, A. B., Walker, L. C., Krieger, S. & De La Hoya, M., 2019, In: Journal of Medical Genetics. 56, 7, p. 453-460

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenosine Monophosphate 100%
  • Alternative Splicing 97%
  • Breast 45%
  • Medical Genetics 40%
  • Molecular Pathology 34%

• Comprehensive Assessment of BARD1 Messenger Ribonucleic Acid Splicing With Implications for Variant Classification

  Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., Behar, R., Houdayer, C., Investigators, K. C. F., Parsons, M. T., Kennedy, M. A., Spurdle, A. B. & de la Hoya, M., 2019 Nov 19, In: Frontiers in Genetics. 10, 1139.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanopore Sequencing 100%
  • Alternative Splicing 64%
  • RNA 61%
  • Exons 49%
  • Medical Genetics 39%

• Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

  Parsons, M. T., Tudini, E., Li, H., Hahnen, E., Wappenschmidt, B., Feliubadaló, L., Aalfs, C. M., Agata, S., Aittomäki, K., Alducci, E., Alonso-Cerezo, M. C., Arnold, N., Auber, B., Austin, R., Azzollini, J., Balmaña, J., Barbieri, E., Bartram, C. R., Blanco, A., Blümcke, B., & 31 othersBonache, S., Bonanni, B., Borg, Å., Bortesi, B., Brunet, J., Bruzzone, C., Bucksch, K., Cagnoli, G., Caldés, T., Caliebe, A., Caligo, M. A., Calvello, M., Capone, G. L., Caputo, S. M., Carnevali, I., Carrasco, E., Caux-Moncoutier, V., Cavalli, P., Cini, G., Clarke, E. M., Concolino, P., Cops, E. J., Cortesi, L., Couch, F. J., Darder, E., de la Hoya, M., Dean, M., Ehrencrona, H., Kvist, A., Törngren, T. & KConFab Investigators, 2019, In: Human Mutation. p. 1557-1578

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Virulence 100%
  • Adenosine Monophosphate 25%
  • Neoplasm Genes 24%
  • Calibration 23%
  • Computational Biology 21%

• Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study

  Esbjörnsson, J., Månsson, F., Kvist, A., da Silva, Z. J., Andersson, S., Fenyö, E. M., Isberg, P. E., Biague, A. J., Lindman, J., Palm, A. A., Rowland-Jones, S. L., Jansson, M., Medstrand, P., Norrgren, H. & Sweden and Guinea-Bissau Cohort Research Group, 2019, In: The Lancet HIV. 6, 1, p. e25-e31

  Research output: Contribution to journal › Article › peer-review

  • Guinea-Bissau 100%
  • HIV-2 81%
  • Acquired Immunodeficiency Syndrome 52%
  • HIV-1 50%
  • Cohort Studies 42%

• Low Postseroconversion CD4⁺ T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection

  Palm, A. A., Lemey, P., Jansson, M., Månsson, F., Kvist, A., Szojka, Z., Biague, A., da Silva, Z. J., Rowland-Jones, S. L., Norrgren, H., Esbjörnsson, J. & Medstrand, P., 2019 Jan 8, In: mBio. 10, 1, e01245-18.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HIV-2 100%
  • HIV Infections 68%
  • Disease Progression 61%
  • T-Lymphocytes 47%
  • Viruses 12%

• Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort

  Li, J., Wen, W. X., Eklund, M., Kvist, A., Eriksson, M., Christensen, H. N., Torstensson, A., Bajalica-Lagercrantz, S., Dunning, A. M., Decker, B., Allen, J., Luccarini, C., Pooley, K., Simard, J., Dorling, L., Easton, D. F., Teo, S. H., Hall, P., Borg, Å., Grönberg, H., & 1 othersCzene, K., 2019 Mar 1, In: International Journal of Cancer. 144, 5, p. 1195-1204

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Logistic Models 29%
  • Guidelines 28%
  • Ovarian Neoplasms 20%
  • Neoplasms 14%

• Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes

  Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., Kvist, A., Vega, A., Gutiérrez-Enríquez, S., Díez, O., de la Hoya, M., Spurdle, A. B., De Meyer, T. & Blok, M. J., 2019, In: International Journal of Cancer. 145, 2, p. 401-414

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • RNA-Seq 88%
  • Ovarian Neoplasms 69%
  • RNA Splicing 51%
  • Breast Neoplasms 48%

• Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study

  Staaf, J., Glodzik, D., Bosch, A., Vallon-Christersson, J., Reuterswärd, C., Häkkinen, J., Degasperi, A., Amarante, T. D., Saal, L. H., Hegardt, C., Stobart, H., Ehinger, A., Larsson, C., Rydén, L., Loman, N., Malmberg, M., Kvist, A., Ehrencrona, H., Davies, H. R., Borg, Å., & 1 othersNik-Zainal, S., 2019, In: Nature Medicine. 25, p. 1526–1533

  Research output: Contribution to journal › Article › peer-review

  • Adjuvant 100%
  • Triple Negative Breast Neoplasms 97%
  • Whole Genome Sequencing 94%
  • Mutation 68%
  • Clinical Studies 56%
• 2018

  BRCAsearch: written pre-test information and BRCA1/2 germline mutation testing in unselected patients with newly diagnosed breast cancer

  Nilsson, M. P., Törngren, T., Henriksson, K., Kristoffersson, U., Kvist, A., Silfverberg, B., Borg, Å. & Loman, N., 2018, In: Breast Cancer Research and Treatment. 168, 1, p. 117-126

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Germ-Line Mutation 100%
  • Genetic Counseling 58%
  • Breast Neoplasms 56%
  • Mutation 39%
  • Genetic Testing 36%

• Gene-panel testing of breast and ovarian cancer patients identifies a recurrent RAD51C duplication

  Pelttari, L. M., Shimelis, H., Toiminen, H., Kvist, A., Törngren, T., Borg, A., Blomqvist, C., Bützow, R., Couch, F., Aittomäki, K. & Nevanlinna, H., 2018, In: Clinical Genetics. 93, 3, p. 595-602

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovarian Neoplasms 100%
  • Breast Neoplasms 70%
  • Mutation 61%
  • Genes 44%
  • Population Control 21%

• Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility

  Catucci, I., Osorio, A., Arver, B., Neidhardt, G., Bogliolo, M., Zanardi, F., Riboni, M., Minardi, S., Pujol, R., Azzollini, J., Peissel, B., Manoukian, S., De Vecchi, G., Casola, S., Hauke, J., Richters, L., Rhiem, K., Schmutzler, R. K., Wallander, K., Törngren, T., & 8 othersBorg, Å., Radice, P., Surrallés, J., Hahnen, E., Ehrencrona, H., Kvist, A., Benitez, J. & Peterlongo, P., 2018, In: Genetics in Medicine. 20, p. 452–457 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosome Fragility 100%
  • Fanconi Anemia 77%
  • Breast Neoplasms 36%
  • Drug Therapy 33%
  • Mutation 32%
• 2017

  Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility

  Mantere, T., Tervasmäki, A., Nurmi, A., Rapakko, K., Kauppila, S., Tang, J., Schleutker, J., Kallioniemi, A., Hartikainen, J. M., Mannermaa, A., Nieminen, P., Hanhisalo, R., Lehto, S., Suvanto, M., Grip, M., Jukkola-Vuorinen, A., Tengström, M., Auvinen, P., Kvist, A., Borg, Å., & 6 othersBlomqvist, C., Aittomäki, K., Greenberg, R. A., Winqvist, R., Nevanlinna, H. & Pylkäs, K., 2017 Apr 6, In: Scientific Reports. 7, 1, 766.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Damage 100%
  • Breast Neoplasms 73%
  • Mutation 64%
  • Genes 46%
  • Fanconi Anemia 25%

• Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells

  Rak, J., Foster, K., Potrzebowska, K., Safaee Talkhoncheh, M., Miharada, N., Komorowska, K., Torngren, T., Kvist, A., Borg, Å., Svensson, L., Bonnet, D. & Larsson, J., 2017 Feb 23, In: Blood. 129, 8, p. 950-958 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cytohesin-1 100%
  • Hematopoietic Stem Cells 50%
  • Integrins 21%
  • Cord 21%
  • Fibronectin 20%

• Expanding the genotype–phenotype spectrum in hereditary colorectal cancer by gene panel testing

  Rohlin, A., Rambech, E., Kvist, A., Törngren, T., Eiengård, F., Lundstam, U., Zagoras, T., Gebre-Medhin, S., Borg, Å., Björk, J., Nilbert, M. & Nordling, M., 2017 Apr, In: Familial Cancer. 16, 2, p. 195-203

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Genes 100%
  • Colorectal Neoplasms 73%
  • Genes 37%
  • Phenotype 31%
  • Genotype 18%

• FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population

  Kiiski, J. I., Tervasmäki, A., Pelttari, L. M., Khan, S., Mantere, T., Pylkäs, K., Mannermaa, A., Tengström, M., Kvist, A., Borg, Å., Kosma, V-M., Kallioniemi, A., Schleutker, J., Bützow, R., Blomqvist, C., Aittomäki, K., Winqvist, R. & Nevanlinna, H., 2017, In: Breast Cancer Research and Treatment. 166, 1, p. 217-226

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Breast Neoplasms 52%
  • Mutation 46%
  • Familial Breast Cancer 39%
  • Population 32%

• Frequent miRNA-convergent fusion gene events in breast cancer

  Persson, H., Søkilde, R., Häkkinen, J., Pirona, A. C., Vallon-Christersson, J., Kvist, A., Mertens, F., Borg, Å., Mitelman, F., Höglund, M. & Rovira, C., 2017 Dec 1, In: Nature Communications. 8, 1, 788.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNA 100%
  • genes 95%
  • Gene Fusion 92%
  • breast 85%
  • cancer 76%

• Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

  Lauss, M., Donia, M., Harbst, K., Andersen, R., Mitra, S., Rosengren, F., Salim, M., Vallon-Christersson, J., Törngren, T., Kvist, A., Ringnér, M., Svane, I. M. & Jönsson, G., 2017 Dec 1, In: Nature Communications. 8, 1, 1738.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • therapy 100%
  • Cell- and Tissue-Based Therapy 99%
  • Biological Marker 94%
  • Mutation 88%
  • Antigen 87%

• NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics

  Cirenajwis, H., Lauss, M., Ekedahl, H., Törngren, T., Kvist, A., Saal, L. H., Olsson, H., Staaf, J., Carneiro, A., Ingvar, C., Harbst, K., Hayward, N. K. & Jönsson, G. B., 2017 Apr, In: Molecular Oncology. 11, 4, p. 438-451 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melanoma 100%
  • Mutation 53%
  • Neoplasms 38%
  • Uveal melanoma 31%
  • Sunlight 29%
• 2016

  Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

  Galeev, R., Baudet, A., Kumar, P., Rundberg Nilsson, A., Nilsson, B., Soneji, S., Törngren, T., Borg, Å., Kvist, A. & Larsson, J., 2016, In: Cell Reports. 14, 12, p. 2988-3000 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Modifier Genes 100%
  • cohesins 99%
  • Hematopoietic Stem Cells 68%
  • RNA Interference 66%
  • Genome 47%

• Multiregion whole-exome sequencing uncovers the genetic evolution and mutational heterogeneity of early-stage metastatic melanoma

  Harbst, K., Lauss, M., Cirenajwis, H., Isaksson, K., Rosengren, F., Törngren, T., Kvist, A., Johansson, M. C., Vallon-Christersson, J., Baldetorp, B., Borg, Å., Olsson, H., Ingvar, C., Carneiro, A. & Jönsson, G. B., 2016 Aug 15, In: Cancer Research. 76, 16, p. 4765-4774 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Evolution 100%
  • Whole Exome Sequencing 92%
  • Melanoma 64%
  • Mutation 34%
  • Neoplasms 25%

• Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic

  Winter, C., Nilsson, M. P., Olsson, E., George, A. M., Chen, Y., Kvist, A., Törngren, T., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Jönsson, G., Grabau, D., Malmberg, M., Kristoffersson, U., Rehn, M., Gruvberger-Saal, S. K., Larsson, C., Borg, Å., Loman, N. & Saal, L. H., 2016 Aug, In: Annals of Oncology. 27, 8, p. 1532-8 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Mutation 87%
  • Germ-Line Mutation 66%
  • BRCA2 Gene 28%
  • BRCA1 Gene 26%
• 2015

  FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.

  Peterlongo, P., Catucci, I., Colombo, M., Caleca, L., Mucaki, E., Bogliolo, M., Marin, M., Damiola, F., Bernard, L., Pensotti, V., Volorio, S., Dall'Olio, V., Meindl, A., Bartram, C., Sutter, C., Surowy, H., Sornin, V., Dondon, M-G., Eon-Marchais, S., Stoppa-Lyonnet, D., & 76 othersAndrieu, N., Sinilnikova, O. M., Mitchell, G., James, P. A., Thompson, E., Marchetti, M., Verzeroli, C., Tartari, C., Capone, G. L., Putignano, A. L., Genuardi, M., Medici, V., Marchi, I., Federico, M., Tognazzo, S., Matricardi, L., Agata, S., Dolcetti, R., Puppa, L. D., Cini, G., Gismondi, V., Viassolo, V., Perfumo, C., Mencarelli, M. A., Baldassarri, M., Peissel, B., Roversi, G., Silvestri, V., Rizzolo, P., Spina, F., Vivanet, C., Tibiletti, M. G., Caligo, M. A., Gambino, G., Tommasi, S., Pilato, B., Tondini, C., Corna, C., Bonanni, B., Barile, M., Osorio, A., Benitez, J., Balestrino, L., Ottini, L., Manoukian, S., Pierotti, M. A., Renieri, A., Varesco, L., Couch, F. J., Wang, X., Devilee, P., Hilbers, F. S., van Asperen, C. J., Viel, A., Montagna, M., Cortesi, L., Diez, O., Balmaña, J., Hauke, J., Schmutzler, R. K., Papi, L., Pujana, M. A., Lázaro, C., Falanga, A., Offit, K., Vijai, J., Campbell, I., Burwinkel, B., Kvist, A., Ehrencrona, H., Mazoyer, S., Pizzamiglio, S., Verderio, P., Surralles, J., Rogan, P. K. & Radice, P., 2015, In: Human Molecular Genetics. 24, 18, p. 5345-5355

  Research output: Contribution to journal › Article › peer-review

  • Familial Breast Cancer 100%
  • Nonsense Codon 79%
  • DNA Repair 64%
  • Exons 57%
  • Odds Ratio 44%

• Molecular stratification of metastatic melanoma using gene expression profiling: prediction of survival outcome and benefit from molecular targeted therapy.

  Cirenajwis, H., Ekedahl, H., Lauss, M., Harbst, K., Carneiro, A., Enoksson, J., Rosengren, F., Werner Hartman, L., Törngren, T., Kvist, A., Fredlund, E., Bendahl, P-O., Jirström, K., Lundgren, L., Howlin, J., Borg, Å., Gruvberger, S., Saal, L., Nielsen, K., Ringnér, M., & 5 othersTsao, H., Olsson, H., Ingvar, C., Staaf, J. & Jönsson, G. B., 2015, In: Oncotarget. 6, 14, p. 12297-12309

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Molecular Targeted Therapy 100%
  • Gene Expression Profiling 76%
  • Melanoma 61%
  • Survival 40%
  • Phenotype 25%
  454 Downloads (Pure)
• 2014

  Effect of HIV-2 infection on HIV-1 disease progression and mortality.

  Esbjörnsson, J., Månsson, F., Kvist, A., Isberg, P-E., Nowroozalizadeh, S., Biague, A. J., da Silva, Z. J., Jansson, M., Fenyö, E. M., Norrgren, H. & Medstrand, P., 2014, In: AIDS. 28, 4, p. 614-615

  Research output: Contribution to journal › Letter › peer-review

• Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02_AG compared to sub subtype A3.

  Palm, A., Esbjörnsson, J., Månsson, F., Kvist, A., Isberg, P-E., Biague, A., da Silva, Z. J., Jansson, M., Norrgren, H. & Medstrand, P., 2014, In: Journal of Infectious Diseases. 209, 5, p. 721-728

  Research output: Contribution to journal › Article › peer-review

  • HIV-1 100%
  • Acquired Immunodeficiency Syndrome 95%
  • HIV Seropositivity 54%
  • Disease Progression 45%
  • Guinea-Bissau 30%

• Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals

  Esbjörnsson, J., Månsson, F., Kvist, A., Isberg, P-E., Biague, A. J., da Silva, Z. J., Jansson, M., Fenyö, E. M., Norrgren, H. & Medstrand, P., 2014, In: AIDS. 28, 7, p. 949-957

  Research output: Contribution to journal › Article › peer-review

  • HIV-2 100%
  • HIV-1 67%
  • HIV Infections 22%
  • AIDS Vaccines 8%
  • Mortality 6%

• Molecular and genetic diversity in the metastatic process of melanoma.

  Harbst, K., Lauss, M., Cirenajwis, H., Winter, C., Howlin, J., Törngren, T., Kvist, A., Nodin, B., Olsson, E., Häkkinen, J., Jirström, K., Staaf, J., Lundgren, L., Olsson, H., Ingvar, C., Gruvberger, S., Saal, L. & Jönsson, G. B., 2014, In: Journal of Pathology. 233, 1, p. 39-50

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Variation 100%
  • Melanoma 85%
  • Molecular Biology 83%
  • Neoplasm Metastasis 31%
  • Neoplasms 29%

• The HER2-Encoded miR-4728-3p Regulates ESR1 through a Non-Canonical Internal Seed Interaction.

  Newie, I., Sökilde, R., Persson, H., Grabau, D., Rego, N., Kvist, A., von Stedingk, K., Axelson, H., Borg, Å., Vallon-Christersson, J. & Rovira, C., 2014, In: PLoS ONE. 9, 5, e97200.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Seeds 100%
  • MicroRNAs 66%
  • human MIRN367 microRNA 47%
  • Nucleotides 31%
  • erbB-2 Genes 27%
  225 Downloads (Pure)
• 2013

  COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration

  Southey, M. C., Park, D. J., Nguyen-Dumont, T., Campbell, I., Thompson, E., Trainer, A. H., Chenevix-Trench, G., Simard, J., Dumont, M., Soucy, P., Thomassen, M., Jonson, L., Pedersen, I. S., Hansen, T. V. O., Nevanlinna, H., Khan, S., Sinilnikova, O., Mazoyer, S., Lesueur, F., Damiola, F., & 37 othersSchmutzler, R., Meindl, A., Hahnen, E., Dufault, M. R., Chan, T. C., Kwong, A., Barkardottir, R., Radice, P., Peterlongo, P., Devilee, P., Hilbers, F., Benitez, J., Kvist, A., Törngren, T., Easton, D., Hunter, D., Lindstrom, S., Kraft, P., Zheng, W., Gao, Y-T., Long, J., Ramus, S., Feng, B-J., Weitzel, R. N., Nathanson, K., Offit, K., Joseph, V., Robson, M., Schrader, K., Wang, S. M., Kim, Y. C., Lynch, H., Snyder, C., Tavtigian, S., Neuhausen, S., Couch, F. J. & Goldgar, D. E., 2013, In: Breast Cancer Research. 15, 3

  Research output: Contribution to journal › Letter

  Open Access

  File
  169 Downloads (Pure)

• High intrapatient HIV-1 evolutionary rate is associated with CCR5-to-CXCR4 coreceptor switch

  Mild, M., Gray, R. R., Kvist, A., Lemey, P., Goodenow, M. M., Fenyö, E. M., Albert, J., Salemi, M., Esbjörnsson, J. & Medstrand, P., 2013, In: Infection, Genetics and Evolution. 19, p. 369-377

  Research output: Contribution to journal › Article › peer-review

  • human immunodeficiency virus 100%
  • Human immunodeficiency virus 1 97%
  • disease progression 76%
  • HIV-1 69%
  • viruses 51%

• Next-Generation Sequencing Identifies MicroRNAs that Associate with Pathogenic Autoimmune Neuroinflammation in Rats

  Bergman, P., James, T., Kular, L., Ruhrmann, S., Kramarova, T., Kvist, A., Supic, G., Gillett, A., Pivarcsi, A. & Jagodic, M., 2013, In: Journal of Immunology. 190, 8, p. 4066-4075

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • High-Throughput Nucleotide Sequencing 100%
  • MicroRNAs 87%
  • Autoimmune Experimental Encephalomyelitis 50%
  • Multiple Sclerosis 30%
  • Kinetics 12%
• 2012

  Inhibition of HIV-1 disease progression by contemporaneous HIV-2 infection.

  Esbjörnsson, J., Månsson, F., Kvist, A., Isberg, P-E., Nowroozalizadeh, S., Biague, A. J., da Silva, Z. J., Jansson, M., Fenyö, E. M., Norrgren, H. & Medstrand, P., 2012, In: New England Journal of Medicine. 367, 3, p. 224-232

  Research output: Contribution to journal › Article › peer-review

  • HIV-2 100%
  • HIV Infections 68%
  • HIV-1 67%
  • Disease Progression 61%
  • Virus Diseases 56%

• Search for an aetiological virus candidate in chronic lymphocytic leukaemia by extensive transcriptome analysis

  Rego, N., Bianchi, S., Moreno, P., Persson, H., Kvist, A., Pena, A., Oppezzo, P., Naya, H., Rovira, C., Dighiero, G. & Pritsch, O., 2012, In: British Journal of Haematology. 157, 6, p. 709-717

  Research output: Contribution to journal › Article › peer-review

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Gene Expression Profiling 97%
  • Viruses 62%
  • Phorbol Esters 34%
  • Transcriptome 28%
• 2011

  Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene.

  Persson, H., Kvist, A., Rego, N., Staaf, J., Vallon-Christersson, J., Luts, L., Loman, N., Jönsson, G. B., Naya, H., Höglund, M., Borg, Å. & Rovira, C., 2011, In: Cancer Research. 71, 1, p. 78-86

  Research output: Contribution to journal › Article › peer-review

  • MicroRNAs 100%
  • Breast Neoplasms 75%
  • Genes 47%
  • RNA 20%
  • Gene Amplification 17%
• 2010

  Differences in molecular evolution between switch (R5 to R5X4/X4-tropic) and non-switch (R5-tropic only) HIV-1 populations during infection.

  Mild, M., Kvist, A., Esbjörnsson, J., Karlsson, I., Fenyö, E. M. & Medstrand, P., 2010, In: Infection, Genetics and Evolution. 10, p. 356-364

  Research output: Contribution to journal › Article › peer-review

  • Molecular Evolution 100%
  • human immunodeficiency virus 97%
  • Human immunodeficiency virus 1 95%
  • virus 75%
  • infection 72%

• Genome-wide profiling of micro RNAS that associate with susceptibility to experimental neuroinflammation

  Petra, B., Alan, G., Supic, G., Kristina, L., Kvist, A. & Maja, J., 2010, In: Journal of Neuroimmunology. 228, 1-2, p. 82-82

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2009

  MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31.

  Veerla, S., Lindgren, D., Kvist, A., Frigyesi, A., Staaf, J., Persson, H., Liedberg, F., Chebil, G., Gudjonsson, S., Borg, Å., Månsson, W., Rovira, C. & Höglund, M., 2009, In: International Journal of Cancer. 124, p. 2236-2242

  Research output: Contribution to journal › Article › peer-review

  • MicroRNAs 100%
  • Carcinoma 78%
  • Neoplasm Metastasis 73%
  • Neoplasms 38%
  • Muscles 20%

• The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs.

  Persson, H., Kvist, A., Vallon-Christersson, J., Medstrand, P., Borg, Å. & Rovira, C., 2009, In: Nature Cell Biology. 11, 10, p. 1268-1271

  Research output: Contribution to journal › Article › peer-review

  • Untranslated RNA 100%
  • Multiple Drug Resistance 92%
  • RNA 61%
  • MicroRNAs 29%
  • Argonaute Proteins 27%