Research output per year
Research output per year
Personal profile
Research
The tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D4 (LTD4) and prostaglandins (PGE2) and their respective receptors. These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. Several of the observations and ideas are generated from our analyses of human colon cancer materials. Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Cancer and Oncology
Free keywords
- Inflammation
- Leukotrienes
- Colon cancer
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Collaborations the last five years
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The impact of inflammatory lipid mediators on colon cancer-initiating cells.
Bellamkonda, K., Sime, W. & Sjölander, A., 2015, In: Molecular Carcinogenesis. 54, 11, p. 1315-1327Research output: Contribution to journal › Article › peer-review
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CysLT1R Antagonists Inhibit Tumor Growth in a Xenograft Model of Colon Cancer.
Savari, S., Liu, M., Zhang, Y., Sime, W. & Sjölander, A., 2013, In: PLoS ONE. 8, 9, e73466.Research output: Contribution to journal › Article › peer-review
Open AccessFile236 Downloads (Pure) -
Crosstalk between colon cancer cells and macrophages via inflammatory mediators and CD47 promotes tumour cell migration.
Zhang, Y., Sime, W., Juhas, M. & Sjölander, A., 2013, In: European Journal of Cancer. 49, 15, p. 3320-3334Research output: Contribution to journal › Article › peer-review
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Cysteinyl leukotriene receptor expression pattern affects migration of breast cancer cells and survival of breast cancer patients.
Magnusson, C., Liu, J., Ehrnström, R., Manjer, J., Jirström, K., Andersson, T. & Sjölander, A., 2011, In: International Journal of Cancer. Okt, p. 9-22Research output: Contribution to journal › Article › peer-review
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Low expression of CysLT(1)R and high expression of CysLT(2)R mediate good prognosis in colorectal cancer
Magnusson, C., Mezhybovska, M., Lörinc, E., Fernebro, E., Nilbert, M. & Sjölander, A., 2010, In: European Journal of Cancer. 46, 4, p. 826-835Research output: Contribution to journal › Article › peer-review