Ann-Charlotte Kristoffersson

2024

Red blood cell-derived arginase release in hemolytic uremic syndrome

Friberg, N., Arvidsson, I., Tontanahal, A., Kristoffersson, A-C., Gram, M., Kaplan, B. S. & Karpman, D., 2024 Jan 4, In: Journal of Translational Medicine. 22, 1, 16 p., 17.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Complement dysregulation associated with a genetic variant in factor H-related protein 5 in atypical hemolytic uremic syndrome

Aradottir, S. S., Kristoffersson, A-C., Linnér, E. & Karpman, D., 2023 Nov 13, (E-pub ahead of print) In: Pediatric Nephrology. 39, 4, p. 1105–1111 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Factor B Mutation in Monozygotic Twins Discordant for Atypical Hemolytic Uremic Syndrome

Aradottir, S. S., Kristoffersson, A. C., Jensson, B. O., Sulem, P., Gong, H., Palsson, R. & Karpman, D., 2023, In: Kidney International Reports. 8, 5, p. 1097-1101

Research output: Contribution to journal › Article › peer-review

Open Access

Genetic investigation of Nordic patients with complement-mediated kidney diseases

Rydberg, V., Aradottir, S. S., Kristoffersson, A-C., Svitacheva, N. & Karpman, D., 2023, In: Frontiers in Immunology. 14, 1254759.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

IgG Binds Escherichia coli Serine Protease EspP and Protects Mice From E. coli O157:H7 Infection

Tontanahal, A., Sperandio, V., Kovbasnjuk, O., Loos, S., Kristoffersson, A. C., Karpman, D. & Arvidsson, I., 2022 Feb, In: Frontiers in Immunology. 13, 807959.

Research output: Contribution to journal › Article › peer-review

Open Access

Apyrase decreases phage induction and Shiga toxin release from E. coli O157:H7 and has a protective effect during infection

Arvidsson, I., Tontanahal, A., Johansson, K., Kristoffersson, A. C., Kellnerová, S., Berger, M., Dobrindt, U. & Karpman, D., 2022, In: Gut microbes. 14, 1, 2122667.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Aradottir, S. S., Kristoffersson, A. C., Roumenina, L. T., Bjerre, A., Kashioulis, P., Palsson, R. & Karpman, D., 2021 Jun 10, In: Frontiers in Immunology. 12, 690821.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Shiga Toxin-Bearing Microvesicles Exert a Cytotoxic Effect on Recipient Cells Only When the Cells Express the Toxin Receptor

Johansson, K., Willysson, A., Kristoffersson, A. C., Tontanahal, A., Gillet, D., Ståhl, A. L. & Karpman, D., 2020, In: Frontiers in cellular and infection microbiology. 10, 212.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammation

Lopatko Fagerström, I., Ståhl, A. L., Mossberg, M., Tati, R., Kristoffersson, A. C., Kahn, R., Bascands, J. L., Klein, J., Schanstra, J. P., Segelmark, M. & Karpman, D., 2019, In: EBioMedicine. 47, p. 319-328

Research output: Contribution to journal › Article › peer-review

Open Access

Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism

Johansson, K. E., Ståhl, A. L., Arvidsson, I., Loos, S., Tontanahal, A., Rebetz, J., Chromek, M., Kristoffersson, A. C., Johannes, L. & Karpman, D., 2019, In: Scientific Reports. 9, 1, 14362.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Aliskiren inhibits renin-mediated complement activation

Békássy, Z. D., Kristoffersson, A. C., Rebetz, J., Tati, R., Olin, A. I. & Karpman, D., 2018, In: Kidney International. 94, 4, p. 689-700

Research output: Contribution to journal › Article › peer-review

2017

C1-inhibitor decreases the release of vasculitis-like chemotactic endothelial microvesicles

Mossberg, M., Ståhl, A. L., Kahn, R., Kristoffersson, A. C., Tati, R., Heijl, C., Segelmark, M., Leeb-Lundberg, F. & Karpman, D., 2017 Aug 1, In: Journal of the American Society of Nephrology: JASN. 28, 8, p. 2472-2481 10 p.

Research output: Contribution to journal › Article › peer-review

2016

Early terminal complement blockade and C6 deficiency are protective in enterohemorrhagic Escherichia coli-infected mice

Arvidsson, I., Rebetz, J., Loos, S., Herthelius, M., Kristoffersson, A. C., Englund, E., Chromek, M. & Karpman, D., 2016 Aug 15, In: Journal of Immunology. 197, 4, p. 1276-1286 11 p.

Research output: Contribution to journal › Article › peer-review

2015

A Novel Mechanism of Bacterial Toxin Transfer within Host Blood Cell-Derived Microvesicles.

Ståhl, A., Arvidsson, I., Johansson, K., Chromek, M., Rebetz, J., Loos, S., Kristoffersson, A-C., Békassy, Z., Mörgelin, M. & Karpman, D., 2015, In: PLoS Pathogens. 11, 2, e1004619.

Research output: Contribution to journal › Article › peer-review

Open Access

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Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome.

Arvidsson, I., Ståhl, A., Manea Hedström, M., Kristoffersson, A-C., Rylander, C., Westman, J., Storry, J., Olsson, M. L. & Karpman, D., 2015, In: Journal of Immunology. 194, 5, p. 2309-2318

Research output: Contribution to journal › Article › peer-review

2014

The Combined Role of Galactose-Deficient IgA1 and Streptococcal IgA-Binding M Protein in Inducing IL-6 and C3 Secretion from Human Mesangial Cells: Implications for IgA Nephropathy.

Schmitt, R., Ståhl, A., Olin, A., Kristoffersson, A-C., Rebetz, J., Novak, J., Lindahl, G. & Karpman, D., 2014, In: Journal of Immunology. 193, 1, p. 317-326

Research output: Contribution to journal › Article › peer-review

2013

Complement Activation Associated with ADAMTS13 Deficiency in Human and Murine Thrombotic Microangiopathy.

Tati, R., Kristoffersson, A-C., Ståhl, A., Rebetz, J., Wang, L., Licht, C., Motto, D. & Karpman, D., 2013, In: Journal of Immunology. 191, 5, p. 2184-2193

Research output: Contribution to journal › Article › peer-review

Eculizumab in an anephric patient with atypical haemolytic uraemic syndrome and advanced vascular lesions.

Békassy, Z., Kristoffersson, A-C., Cronqvist, M., Roumenina, L. T., Rybkine, T., Vergoz, L., Hue, C., Fremeaux-Bacchi, V. & Karpman, D., 2013, In: Nephrology Dialysis Transplantation. 28, 11, p. 2899-2907

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2012

A Novel C3 Mutation Causing Increased Formation of the C3 Convertase in Familial Atypical Hemolytic Uremic Syndrome.

Sartz, L., Olin, A., Kristoffersson, A-C., Ståhl, A., Johansson, M. E., Westman, K., Fremeaux-Bacchi, V., Nilsson, K. & Karpman, D., 2012, In: Journal of immunology. 188, 4, p. 2030-2037

Research output: Contribution to journal › Article › peer-review

2011

IgA nephropathy associated with a novel N-terminal mutation in factor H.

Schmitt, R., Krmar, R. T., Kristoffersson, A-C., Söderberg, M. & Karpman, D., 2011, In: European Journal of Pediatrics. 170, p. 107-110

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218 Downloads (Pure)

Intestinal damage in enterohemorrhagic Escherichia coli infection.

Békassy, Z., Calderon Toledo, C., Leoj, G., Kristoffersson, A-C., Leopold, S. R., Perez, M. T. & Karpman, D., 2011, In: Pediatric Nephrology. oct, p. 2059-2071

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292 Downloads (Pure)

Phenotypic Expression of ADAMTS13 in Glomerular Endothelial Cells

Tati, R., Kristoffersson, A-C., Ståhl, A-L., Mörgelin, M., Motto, D., Satchell, S., Mathieson, P., Manea Hedström, M. & Karpman, D., 2011, In: PLoS ONE. 6, 6

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Open Access

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Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis

Brackman, D., Sartz, L., Leh, S., Kristoffersson, A-C., Bjerre, A., Tati, R., Fremeaux-Bacchi, V. & Karpman, D., 2011, In: Nephrology Dialysis Transplantation. 26, 10, p. 3399-3403

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739 Downloads (Pure)

2008

Characterization of a novel mutation in the von Willebrand factor propeptide in a distinct subtype of recessive von Willebrand disease.

Lanke, E., Kristoffersson, A-C., Philips, M., Holmberg, L. & Lethagen, S., 2008, In: Thrombosis and Haemostasis. 100, 2, p. 211-216

Research output: Contribution to journal › Article › peer-review

Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients.

Bergenfelz, A., Jansson, S., Kristoffersson, A-C., Mårtensson, H., Reihnér, E., Wallin, G. & Lausen, I., 2008, In: Langenbeck's Archives of Surgery. 393, p. 667-673

Research output: Contribution to journal › Article › peer-review

Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation.

Ståhl, A-L., Vaziri Sani, F., Heinen, S., Kristoffersson, A-C., Gydell, K-H., Raafat, R., Gutierrez, A., Beringer, O., Zipfel, P. F. & Karpman, D., 2008, In: Blood. 111, p. 5307-5315

Research output: Contribution to journal › Article › peer-review

Open Access

N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets.

Lanke, E., Kristoffersson, A-C., Isaksson, C., Holmberg, L. & Lethagen, S., 2008, In: European Journal of Haematology. 81, p. 384-390

Research output: Contribution to journal › Article › peer-review

2007

ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura.

Manea Hedström, M., Kristoffersson, A-C., Tsai, H-M., Zhou, W., Winqvist, I., Oldaeus, G., Billstrom, R., Björk, P., Holmberg, L. & Karpman, D., 2007, In: European Journal of Pediatrics. 166, 3, p. 249-257

Research output: Contribution to journal › Article › peer-review

A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation.

Nilsson, S., Karpman, D., Vaziri Sani, F., Kristoffersson, A-C., Salomon, R., Provot, F., Fremeaux-Bacchi, V., Trouw, L. & Blom, A., 2007, In: Molecular Immunology. 44, 8, p. 1835-1844

Research output: Contribution to journal › Article › peer-review

Podocytes express ADAMTS13 in normal renal cortex and in patients with thrombotic thrombocytopenic purpura

Manea Hedström, M., Kristoffersson, A-C., Schneppenheim, R., Saleem, M. A., Mathieson, P. W., Mörgelin, M., Björk, P., Holmberg, L. & Karpman, D., 2007, In: British Journal of Haematology. 138, 5, p. 651-662

Research output: Contribution to journal › Article › peer-review

2006

Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome.

Vaziri-Sani, F., Holmberg, L., Sjöholm, A., Kristoffersson, A-C., Manea Hedström, M., Frémeaux-Bacchi, V., Fehrman-Ekholm, I., Raafat, R. & Karpman, D., 2006, In: Kidney International. 69, 6, p. 981-988

Research output: Contribution to journal › Article › peer-review

2005

VWF-cleaving protease (ADAMTS13) in premature infants.

Hellström-Westas, L., Ley, D., Berg, A-C., Kristoffersson, A-C. & Holmberg, L., 2005, In: Acta Pædiatrica. 94, 2, p. 205-210

Research output: Contribution to journal › Article › peer-review

1980

Prenatal diagnosis of hemophilia B by an immunoradiometric assay of factor IX

Holmberg, L., Gustavii, B., Cordesius, E., Kristoffersson, A. C., Ljung, R., Löfberg, L., Strömberg, P. & Nilsson, I. M., 1980 Sept, In: Blood. 56, 3, p. 397-401 5 p.

Research output: Contribution to journal › Article › peer-review

Ann-Charlotte Kristoffersson

Research output

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