Anna Darabi

Anna Darabi

Researcher, PhD, Ass. Professor

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Research

Brain tumors represent 1/4 of all cancers in children. Although ca. 50% are cured, the long-term side effects of current therapy are significant. Immunotherapy has proven effective in experimental brain tumor models and several clinical trials have been initiated. Most tumors, including brain tumors in children, contain not only tumor cells, but also various types of immune cells and other stromal cells. These cells interact with tumor cells, via common signaling, and induce inflammation and immunosuppression locally in the tumor, but also systemically. Our research is focused on investigating how the immune system can be modulated from tumor-promoting conditions to a state where the immune system instead helps to reject tumors. We are also working to develop good model systems that represent different types of childhood brain tumors, as there is currently strong demand for such models. These models can be used to answer how tumors respond to new cancer treatments, how current treatment works in tune with new treatments, and provide detailed knowledge of specific interactions between the tumor and surrounding cells.

UKÄ subject classification

  • Cancer and Oncology
  • Immunology in the medical area
  • Pediatrics

Keywords

  • Brain tumor
  • Immunotherapy
  • Medulloblastoma
  • Pediatric brain tumor
  • Inflammation

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