Research output per year
Research output per year
- 49 results
Search results
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2024
Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted
Governa, V., de Oliveira, K. G., Bång-Rudenstam, A., Offer, S., Cerezo-Magaña, M., Li, J., Beyer, S., Johansson, M. C., Månsson, A. S., Edvardsson, C., Durmo, F., Gustafsson, E., Boukredine, A., Jeannot, P., Schmidt, K., Gezelius, E., Menard, J. A., Garza, R., Jakobsson, J. & de Neergaard, T. & 11 others, , 2024 Oct 30, In: Science Translational Medicine. 16, 771, p. eadk1168Research output: Contribution to journal › Article › peer-review
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2023
Antisecretory factor is safe to use as add-on treatment in newly diagnosed glioblastoma
Ehinger, E., Kopecky, J., Darabi, A., Visse, E., Edvardsson, C., Tomasevic, G., Cederberg, D., Belting, M., Bengzon, J. & Siesjö, P., 2023, In: BMC Neurology. 23, 1, 76.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Intratumoral administration of the antisecretory peptide AF16 cures murine gliomas and modulates macrophage functions
Kopecky, J., Pérez, J. E., Eriksson, H., Visse, E., Siesjö, P. & Darabi, A., 2022 Dec, In: Scientific Reports. 12, 4609.Research output: Contribution to journal › Article › peer-review
Open Access -
Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Governa, V., Talbot, H., Gonçalves de Oliveira, K., Cerezo-Magaña, M., Bång-Rudenstam, A., Johansson, M. C., Månsson, A.-S., Forsberg-Nilsson, K., Marko-Varga, G., Enríquez Pérez, J., Darabi, A., Malmström, J., Bengzon, J., Welinder, C. & Belting, M., 2022 Mar 1, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, p. 1-11 e2114456119.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Circular rnas in hedgehog signaling activation and hedgehog‐mediated medulloblastoma tumors
Azatyan, A., Zhang, S., Darabi, A., Siesjö, P., Wang, T. & Zaphiropoulos, P. G., 2021 Oct 2, In: Cancers. 13, 20, 5138.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas
Enríquez Pérez, J., Kopecky, J., Visse, E., Darabi, A. & Siesjö, P., 2020 Jan 3, In: BMC Cancer. 20, 7.Research output: Contribution to journal › Article › peer-review
Open Access -
Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells
Susanto, E., Marin Navarro, A., Zhou, L., Sundström, A., van Bree, N., Stantic, M., Moslem, M., Tailor, J., Rietdijk, J., Zubillaga, V., Hübner, J. M., Weishaupt, H., Wolfsberger, J., Alafuzoff, I., Nordgren, A., Magnaldo, T., Siesjö, P., Johnsen, J. I., Kool, M. & Tammimies, K. & 4 others, , 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20127-20138 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
The molecular landscape of ETMR at diagnosis and relapse
Lambo, S., Darabi, A., Kool, M. & et al., 2019 Dec 4, In: Nature. 576, p. 274-280 7 p.Research output: Contribution to journal › Article › peer-review
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Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
Offer, S., Menard, J., Enriquez Perez, J., Goncalves De Oliveira, K., Indira Chandran, V., Johansson, M. C., Bång-Rudenstam, A., Siesjö, P., Ebbesson, A., Hedenfalk, I., Maly Sundgren, P., Darabi, A. & Belting, M., 2019 Jun 7, In: Journal of Experimental & Clinical Cancer Research. 38, 241.Research output: Contribution to journal › Article › peer-review
Open Access -
The effect of locally delivered cisplatin is dependent on an intact immune function in an experimental glioma model
Enríquez Pérez, J., Fritzell, S., Kopecky, J., Visse, E., Darabi, A. & Siesjö, P., 2019 Apr 4, In: Scientific Reports. 9, 1, 5632.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation
Sandén, E., Dyberg, C., Krona, C., Gallo-Oller, G., Olsen, T. K., Enríquez Pérez, J., Wickström, M., Estekizadeh, A., Kool, M., Visse, E., Ekström, T. J., Siesjö, P., Inge Johnsen, J. & Darabi, A., 2017 Apr 18, In: Scientific Reports. 7, 46366.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-β delineate two distinct groups of children with brain tumors
Sandén, E., Enríquez Pérez, J., Visse, E., Kool, M., Carén, H., Siesjö, P. & Darabi, A., 2016 Dec, In: Pediatric Blood & Cancer. 63, 12, p. 2112-2122Research output: Contribution to journal › Article › peer-review
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2015
Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas.
Sandén, E., Dyberg, C., Krona, C., Visse, E., Carén, H., Northcott, P. A., Kool, M., Ståhl, N., Persson, A., Englund, E., Johnsen, J. I., Siesjö, P. & Darabi, A., 2015, In: Journal of Neuro-Oncology. 123, 1, p. 1-13Research output: Contribution to journal › Article › peer-review
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Al adjuvants can be tracked in viable cells by lumogallion staining.
Mile, I., Svensson, A., Darabi, A., Mold, M., Siesjö, P. & Eriksson, H., 2015, In: Journal of Immunological Methods. 422, Apr 17, p. 87-94Research output: Contribution to journal › Article › peer-review
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A standardized and reproducible protocol for serum-free monolayer culturing of primary paediatric brain tumours to be utilized for therapeutic assays.
Sandén, E., Eberstål, S., Visse, E., Siesjö, P. & Darabi, A., 2015, In: Scientific Reports. 5, 12218.Research output: Contribution to journal › Article › peer-review
Open Access -
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.
Wickström, M., Dyberg, C., Milosevic, J., Einvik, C., Calero, R., Sveinbjörnsson, B., Sandén, E., Darabi, A., Siesjö, P., Kool, M., Kogner, P., Baryawno, N. & Johnsen, J. I., 2015, In: Nature Communications. 6, 8904.Research output: Contribution to journal › Article › peer-review
Open Access -
2014
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
Northcott, P. A., Lee, C., Zichner, T., Stütz, A. M., Erkek, S., Kawauchi, D., Shih, D. J. H., Hovestadt, V., Zapatka, M., Sturm, D., Jones, D. T. W., Kool, M., Remke, M., Cavalli, F. M. G., Zuyderduyn, S., Bader, G. D., VandenBerg, S., Esparza, L. A., Ryzhova, M. & Wang, W. & 59 others, , 2014, In: Nature. 511, 7510, p. 428Research output: Contribution to journal › Article › peer-review
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HLA-I Antigen Presentation and Tapasin Influence Immune Responses Against Malignant Brain Tumors - Considerations for Successful Immunotherapy.
Darabi, A., Thuring, C. & Paulsson, K. M., 2014, In: Anti-Cancer Agents in Medicinal Chemistry. 14, 8, p. 1094-1100Research output: Contribution to journal › Article › peer-review
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Immunizations with unmodified tumor cells and simultaneous COX-2 inhibition eradicate malignant rat brain tumors and induce a long-lasting CD8(+) T cell memory.
Eberstål, S., Fritzell, S., Sandén, E., Visse, E., Darabi, A. & Siesjö, P., 2014, In: Journal of Neuroimmunology. 274, 1-2, p. 161-167Research output: Contribution to journal › Article › peer-review
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Intratumoral COX-2 inhibition enhances GM-CSF immunotherapy against established mouse GL261 brain tumors.
Eberstål, S., Sandén, E., Fritzell, S., Darabi, A., Visse, E. & Siesjö, P., 2014, In: International Journal of Cancer. 134, 11, p. 2748-2753Research output: Contribution to journal › Article › peer-review
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Intratumorally implanted mesenchymal stromal cells potentiate peripheral immunotherapy against malignant rat gliomas.
Ströjby, S., Eberstål, S., Svensson, A., Fritzell, S., Bexell, D., Siesjö, P., Darabi, A. & Bengzon, J., 2014, In: Journal of Neuroimmunology. 274, 1-2, p. 240-243Research output: Contribution to journal › Article › peer-review
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Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line.
Mold, M., Eriksson, H., Siesjö, P., Darabi, A., Shardlow, E. & Exley, C., 2014, In: Scientific Reports. 4, 6287.Research output: Contribution to journal › Article › peer-review
Open AccessFile206 Downloads (Pure) -
2013
Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.
Sehic, D., Forslund, O., Sandén, E., Holmquist Mengelbier, L., Karlsson, J., Bzhalava, D., Ekström, J., Warenholt, J., Darabi, A., Dillner, J., Øra, I. & Gisselsson Nord, D., 2013, In: Pediatric Blood & Cancer. 60, 9, p. E91-E93Research output: Contribution to journal › Article › peer-review
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Aluminium based adjuvants and their effects on mitochondria and lysosomes of phagocytosing cells
Ohlsson, L., Exley, C., Darabi, A., Sandén, E., Siesjö, P. & Eriksson, H., 2013, In: Journal of Inorganic Biochemistry. 128, p. 229-236Research output: Contribution to journal › Article › peer-review
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IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models.
Fritzell, S., Eberstål, S., Sandén, E., Visse, E., Darabi, A. & Siesjö, P., 2013, In: Journal of Neuroimmunology. 258, 1-2, p. 91-95Research output: Contribution to journal › Article › peer-review
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Intratumoral temozolomide synergizes with immunotherapy in a T cell-dependent fashion.
Fritzell, S., Sandén, E., Eberstål, S., Visse, E., Darabi, A. & Siesjö, P., 2013, In: Cancer Immunology and Immunotherapy. 62, 9, p. 1463-1474Research output: Contribution to journal › Article › peer-review
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PD-L1 Expression by Neurons Nearby Tumors Indicates Better Prognosis in Glioblastoma Patients.
Liu, Y., Carlsson, R., Ambjørn, M., Hasan, M., Badn, W., Darabi, A., Siesjö, P. & Issazadeh, S., 2013, In: The Journal of Neuroscience. 33, 35, p. 14231-14245Research output: Contribution to journal › Article › peer-review
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2012
Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors.
Eberstål, S., Badn, W., Fritzell, S., Esbjörnsson, M., Darabi, A., Visse, E. & Siesjö, P., 2012, In: Cancer immunology, immunotherapy. 61, 8, p. 1191-1199Research output: Contribution to journal › Article › peer-review
File311 Downloads (Pure) -
2011
Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target
Baryawno, N., Rahbar, A., Wolmer-Solberg, N., Taher, C., Odeberg, J., Darabi, A., Khan, Z., Sveinbjornsson, B., Fuskevag, O.-M., Segerstrom, L., Nordenskjold, M., Siesjö, P., Kogner, P., Johnsen, J. I. & Soderberg-Naucler, C., 2011, In: Journal of Clinical Investigation. 121, 10, p. 4043-4055Research output: Contribution to journal › Article › peer-review
File329 Downloads (Pure) -
2010
Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.
Gunnarsson, S., Bexell, D., Svensson, A., Siesjö, P., Darabi, A. & Bengzon, J., 2010, In: Journal of Neuroimmunology. 218, 1-2, p. 140-144Research output: Contribution to journal › Article › peer-review
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2009
Bone Marrow Multipotent Mesenchymal Stroma Cells Act as Pericyte-like Migratory Vehicles in Experimental Gliomas.
Bexell, D., Gunnarsson, S., Tormin, A., Darabi, A., Gisselsson Nord, D., Roybon, L., Scheding, S. & Bengzon, J., 2009, In: Molecular Therapy. 2008, Nov 4., p. 183-190Research output: Contribution to journal › Article › peer-review
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CD133+ and nestin+ tumor-initiating cells dominate in N29 and N32 experimental gliomas.
Bexell, D., Gunnarsson, S., Siesjö, P., Bengzon, J. & Darabi, A., 2009, In: International Journal of Cancer. 125, 1, p. 15-22Research output: Contribution to journal › Article › peer-review
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Cure of established GL261 mouse gliomas after combined immunotherapy with GM-CSF and IFNgamma is mediated by both CD8(+) and CD4(+) T-cells.
Enell Smith, K., Fritzell, S., Badn, W., Eberstål, S., Janelidze, S., Visse, E., Darabi, A. & Siesjö, P., 2009, In: International Journal of Cancer. 124, 3, p. 630-637Research output: Contribution to journal › Article › peer-review
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Identification of proteins involved in neural progenitor cell targeting of gliomas
Staflin, K., Zuchner, T., Honeth, G., Darabi, A. & Lundberg, C., 2009, In: BMC Cancer. 9Research output: Contribution to journal › Article › peer-review
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Immunizations With IFN gamma Secreting Tumor Cells can Eliminate Fully Established and Invasive Rat Gliomas
Janelidze, S., Bexell, D., Badn, W., Darabi, A., Enell Smith, K., Fritzell, S., Gunnarsson, S., Milos, P., Bengzon, J., Salford, L., Siesjö, P. & Visse, E., 2009, In: Journal of Immunotherapy. 32, 6, p. 593-601Research output: Contribution to journal › Article › peer-review
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Immunizations with IFNgamma secreting tumor cells can eliminate fully established and invasive rat gliomas.
Janelidze, S., Bexell, D., Badn, W., Darabi, A., Enell Smith, K., Fritzell, S., Gunnarsson, S., Milos, P., Bengzon, J., Salford, L., Siesjö, P. & Visse, E., 2009, In: Journal of Immunotherapy. 32, 6, p. 593-601Research output: Contribution to journal › Article › peer-review
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The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I
Roder, G., Geironson Ulfsson, L., Darabi, A., Harndahl, M., Schafer-Nielsen, C., Skjodt, K., Buus, S. & Paulsson, K. M., 2009, In: European Journal of Immunology. 39, 10, p. 2682-2694Research output: Contribution to journal › Article › peer-review
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Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy
van der Most, R. G., Currie, A. J., Mahendran, S., Prosser, A., Darabi, A., Robinson, B. W. S., Nowak, A. K. & Lake, R. A., 2009, In: Cancer Immunology and Immunotherapy. 58, 8, p. 1219-1228Research output: Contribution to journal › Article › peer-review
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2007
Inhibition of Inducible Nitric Oxide Synthase Enhances Anti-tumour Immune Responses in Rats Immunized with IFN-gamma-Secreting Glioma Cells.
Badn, W., Hegardt, P., Agemark, M., Darabi, A., Esbjörnsson, M., Smith, K. E., Janelidze, S., Salford, L., Visse, E. & Siesjö, P., 2007, In: Scandinavian Journal of Immunology. 65, 3, p. 289-297Research output: Contribution to journal › Article › peer-review
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Postimmunization with IFN-gamma-secreting glioma cells combined with the inducible nitric oxide synthase inhibitor mercaptoethylguanidine prolongs survival of rats with intracerebral tumors
Badn, W., Visse, E., Darabi, A., Enell Smith, K., Salford, L. & Siesjö, P., 2007, In: Journal of Immunology. 179, 6, p. 4231-4238Research output: Contribution to journal › Article › peer-review
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Synergism between GM-CSF and IFNgamma: Enhanced immunotherapy in mice with glioma.
Smith, K. E., Janelidze, S., Visse, E., Badn, W., Salford, L., Siesjö, P. & Darabi, A., 2007, In: International Journal of Cancer. 120, 1, p. 75-80Research output: Contribution to journal › Article › peer-review
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2005
Activation of purified allogeneic CD4(+) T cells by rat bone marrow-derived dendritic cells induces concurrent secretion of IFN-gamma, IL-4, and IL-10.
Janelidze, S., Enell Smith, K., Visse, E., Darabi, A., Salford, L. & Siesjö, P., 2005, In: Immunology Letters. 101, 2, p. 193-201Research output: Contribution to journal › Article › peer-review
File156 Downloads (Pure) -
2004
Abstracts from the Ninth Annual Meeting of the Society for Neuro-Oncology
Salford, L., Siesjö, P., Skagerberg, G., Visse, E., Darabi, A., Lilja, Å., Blennow, C., Strömblad, S., Ask, E., Rydelius, A., Persson, B. R., Baureus Koch, C., Englund, E., Larsson, E.-M., Mandahl, N. & Widegren, B., 2004, In: Neuro-Oncology. 6, 4, p. 307-400Research output: Contribution to journal › Article › peer-review
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Identification and characterization of a human smad3 splicing variant lacking part of the linker region.
Kjellman, C., Honeth, G., Järnum, S., Lindvall, M., Darabi, A., Nilsson, I., Edvardsen, K., Salford, L. & Widegren, B., 2004, In: Gene. 327, 2, p. 141-152Research output: Contribution to journal › Article › peer-review
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LEPREL1, a novel ER and Golgi resident member of the Leprecan family.
Järnum, S., Kjellman, C., Darabi, A., Nilsson, I., Edvardsen, K. & Aman, P., 2004, In: Biochemical and Biophysical Research Communications. 317, 2, p. 342-351Research output: Contribution to journal › Article › peer-review
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2002
Enhanced expression of iNOS intratumorally and at the immunization site after immunization with IFNgamma-secreting rat glioma cells
Johansson, A. C., Hegardt, P., Janelidze, S., Visse, E., Widegren, B. & Siesjö, P., 2002, In: Journal of Neuroimmunology. 123, 1-2, p. 135-143 9 p., 123.Research output: Contribution to journal › Article › peer-review
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2001
Computerized image analysis as a tool to quantify infiltrating leukocytes: a comparison between high- and low-magnification images
C Johansson, A., Visse, E., Widegren, B., Sjögren, H. O. & Siesjö, P., 2001 Sept, In: Journal of Histochemistry and Cytochemistry. 49, 9, p. 1073-79 7 p.Research output: Contribution to journal › Article › peer-review
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2000
Immunohistochemical analysis of glioma-infiltrating leucocytes after peripheral therapeutic immunization with interferon-gamma-transfected glioma cells
Visse, E., C Johansson, A., Widegren, B., Sjögren, H. O. & Siesjö, P., 2000 Jun, In: Cancer Immunology and Immunotherapy. 49, 3, p. 142-151 10 p.Research output: Contribution to journal › Article › peer-review
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Effects of transforming growth factor beta1 expression in a rat colon carcinoma: growth inhibition, leukocyte infiltration and production of interleukin-10 and tumor necrosis factor alpha
Schiött, A., Widegren, B., Sjögren, H. O., Lindvall, M. & C Johansson, A., 2000 Jan, In: Cancer Immunology and Immunotherapy. 48, 10, p. 579-587 9 p.Research output: Contribution to journal › Article › peer-review