Anna Hagström-Andersson

Senior lecturer, Principal Investigator

Personal profile


Acute leukemia in infants (less than one year of age) is characterized by rearrangements of the Mixed Lineage Leukemia (MLL) gene (MLL-R) and a very poor survival. MLL-R leukemia can also be found in children above one year of age; these typically have a better survival. Thus, new therapeutic approaches are needed to improve the cure rates for these patients, in particular for infant ALL.

My research efforts focus on defining the landscape of epigenetic and genetic lesions that underlie pediatric MLL-R leukemia at diagnosis and at relapse. We use high-resolution genomic methods to identify aberrant genes and signaling pathways, in combination with murine models, to unravel their impact on tumor behavior. These studies will enhance our understanding of the differences between infant and non-infant MLL-R leukemia, and the nature of alterations that drive its development, and will increase our understanding about the genetic basis of relapse. In addition, we are interested in defining how distinct tumor clones cooperate to drive the growth of MLL-R leukemia, and the mechanisms behind clonal cooperation using murine models and in vitro assays to determine its biological significance. Our studies will advance our understanding of leukemogenesis, and may influence how leukemia is diagnosed, classified and treated in the future, and will help identify targets for novel treatment modalities.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Cancer and Oncology

Free keywords

  • Leukemia
  • MLL
  • Mouse models


Dive into the research topics where Anna Hagström-Andersson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or