Annika Jögi

Läkare, Affiliated with the university, Associate professor, M. Sci., M. Med.

Personal profile


Impact of the tumor microenvironment and hypoxia on breast cancer and therapy resistance


Breast cancer is the most common cancer in women with ~9000 cases yearly in Sweden. Treatment with surgery, often combined with additional therapy such as radiation and anti-estrogens, relieves tumor burden. In some cases re-growth or metastasis occur, which is linked to poor patient outcome.

The microenvironment within tumors differs from that of healthy tissues, especially oxygen delivery is poor leading to hypoxia. Intra tumor hypoxia leads to poor response to several cancer therapies including anti-estrogens, chemo and radiation.

We want to explore why some patients experience cancer recurrence, metastasis and therapy resistance with the aim to improve and specialize treatment. Therefore we molecularly map how hypoxia and factors induced by hypoxia contribute to anti-estrogen resistance. In parallel we investigate how the presence of intra-tumor hypoxia correlates to patient outcome.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Medical and Health Sciences
  • Cell Biology
  • Basic Medicine
  • Cell and Molecular Biology
  • Cancer and Oncology

Free keywords

  • Cancer and Oncology
  • Tumor microenvironment
  • Breast cancer
  • Therapy resistance
  • Tumor models
  • Tumor hypoxia


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Collaborations the last five years

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