Research output per year
Research output per year
Personal profile
Research
Impact of the tumor microenvironment and hypoxia on breast cancer and therapy resistance
Breast cancer is the most common cancer in women with ~9000 cases yearly in Sweden. Treatment with surgery, often combined with additional therapy such as radiation and anti-estrogens, relieves tumor burden. In some cases re-growth or metastasis occur, which is linked to poor patient outcome.
The microenvironment within tumors differs from that of healthy tissues, especially oxygen delivery is poor leading to hypoxia. Intra tumor hypoxia leads to poor response to several cancer therapies including anti-estrogens, chemo and radiation.
We want to explore why some patients experience cancer recurrence, metastasis and therapy resistance with the aim to improve and specialize treatment. Therefore we molecularly map how hypoxia and factors induced by hypoxia contribute to anti-estrogen resistance. In parallel we investigate how the presence of intra-tumor hypoxia correlates to patient outcome.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Subject classification (UKÄ)
- Basic Cancer Research
- Medical and Health Sciences
- Cell Biology
- Basic Medicine
- Cell and Molecular Biology
- Cancer and Oncology
Free keywords
- Cancer and Oncology
- Tumor microenvironment
- Breast cancer
- Therapy resistance
- Tumor models
- Tumor hypoxia
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.
Alam, M. W., Persson, C., Reinbothe, S., Kazi, J. U., Rönnstrand, L., Wigerup, C., Ditzel, H. J., Lykkesfeldt, A. E., Påhlman, S. & Jögi, A., 2016 Mar, In: Oncotarget. 7, 10, p. 11238-50Research output: Contribution to journal › Article › peer-review
Open Access -
Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution.
Påhlman, S., Lund, L. R. & Jögi, A., 2015, In: PLoS ONE. 10, 5, e0125771.Research output: Contribution to journal › Article › peer-review
Open AccessFile233 Downloads (Pure) -
Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR
Almholt, K., Laerum, O. D., Nielsen, B. S., Lund, I. K., Lund, L. R., Romer, J. & Jögi, A., 2015, In: Clinical and Experimental Metastasis. 32, 6, p. 543-554Research output: Contribution to journal › Article › peer-review
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Tumour hypoxia and the hypoxia inducible transcription factors: Key players in cancer progression and metastasis
Jögi, A., 2015, Tumor cell metabolism : Pathways, Regulation and Biology. Mazurek, S. & Shoshan, M. (eds.). Heidelberg: Springer, p. 65-98Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
Vaapil, M., Helczynska, K., Villadsen, R., Petersen, O. W., Johansson, E., Beckman, S., Larsson, C., Påhlman, S. & Jögi, A., 2012, In: PLoS ONE. 7, 9, e46543.Research output: Contribution to journal › Article › peer-review
Open AccessFile273 Downloads (Pure)
Activities
- 1 Public lecture/debate/seminar
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Hur sprids cancer?
Jögi, A. (Lecturer)
2014 Apr 10Activity: Talk or presentation › Public lecture/debate/seminar