I currently aim to unveil the interplay of human host proteins with Gram-positive anaerobic cocci during infection. Infections with Gram-positive anaerobic cocci (GPAC) can cause mild diseases as well as severe invasive conditions, such as sepsis and necrotizing fasciitis. Reduced susceptibility towards certain antibiotics alongside existing comorbidities amplify the risk of detrimental outcome for the host. Interactions between host and bacterial proteins are highly significant for pathogenesis and virulence.Virulence factors of GPAC species F. magna, such as F. magna adhesion factor (FAF) and Protein L have been associated with binding to host proteins and induction of clinical infection. Applying a range of molecular, cellular and biophysical methods (e.g. Infection assays, Circular Dichroism, Fluorescence Spectroscopy, Surface Plasmon Resonance, Flow cytometry, Mass Spectrometry), my research aims to provide novel and crucial information needed to target GPAC infections, thus promoting the development of potential preventive and therapeutic strategies.