Research output per year
Research output per year
Professor, consultant
Innate host defense molecules as biomarkers and therapeutic targets in chronic airway inflammation
COPD, asthma, and cystic fibrosis (CF) together affect a large number of individuals and no curative treatments are available. These diseases have in common that they start at the airway mucosal surfaces and inflammatory bouts (exacerbations) are to a large extent triggered by infections. In this project, we study innate host defense, with a focus on roles for chemokines and innate antibiotics during airway inflammation. These molecules are important both in the context of the prolonged and dysregulated inflammation as well as during the exacerbations seen COPD, asthma, and CF.
The project applies experimental models reflecting mucosal inflammation as well as investigation of clinical samples. The production of antibacterial chemokines by inflamed epithelial cells demonstrates an important aspect of innate immunity. It is therefore important to increase the knowledge concerning mechanisms regulating their expression in airway epithelial cells. In addition, antibacterial chemokines can serve as both biomarkers and templates to develop new treatment strategies against inflammatory bouts of COPD, asthma, and CF.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Egesten, A. (PI)
Swedish Government Agency for Innovation Systems (Vinnova)
2023/04/03 → 2025/12/31
Project: Research
Isholt, H. (Researcher), Akbarshahi, H. (Supervisor) & Egesten, A. (Assistant supervisor)
2023/02/01 → …
Project: Research
Egesten, A. (Researcher)
Swedish Research Council, The Swedish Heart Lung Foundation
2020/01/01 → 2027/12/31
Project: Research
Schmidtchen, A. (Project coordinator), Albiger, B. (Researcher), Björck, L. (Researcher), Collin, M. (Researcher), Herwald, H. (Researcher), Frick, I.-M. (Researcher), Shannon, O. (Researcher), Sörensen, O. (Researcher), Egesten, A. (Researcher), Malmström, J. (Researcher), Borrebaeck, C. (Researcher), Sterner, O. (Researcher), Hederstedt, L. (Researcher), Ausmees, N. (Researcher), Flärdh, K. (Researcher), von Wachenfeldt, C. (Researcher), Holst, E. (Researcher) & Forsén, S. (Researcher)
2010/08/10 → 2011/08/10
Project: Network