Björn Dahlbäck

2024

Importance of individual residues in hydrophobic patch PLVIVGL (1481-1487) in FV-Short for synergistic TFPIα cofactor activity with protein S, an alanine-scanning study: AlphaFold-mediated prediction of FV-Short/TFPIα/protein S trimolecular complex structure

Dahlbäck, B., Tran, S. & Draczkowski, P., 2024 Nov 29, (E-pub ahead of print) In: Journal of thrombosis and haemostasis : JTH. p. 1-14

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular coagulation and thrombophilia

Dahlbäck, B. & Hillarp, A., 2024 Mar 8, Molecular Hematology. Provan, D. & Lazarus, H. (eds.). 5 ed. Wiley, p. 201-215

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2023

Natural anticoagulant discovery, the gift that keeps on giving: finding FV-Short

Dahlbäck, B., 2023 Apr, In: Journal of Thrombosis and Haemostasis. 21, 4, p. 716-727 12 p.

Research output: Contribution to journal › Review article › peer-review

2022

Diagnosis and management of severe congenital protein C deficiency (SCPCD): Communication from the SSC of the ISTH

Minford, A., Brandão, L. R., Othman, M., Male, C., Abdul-Kadir, R., Monagle, P., Mumford, A. D., Adcock, D., Dahlbäck, B., Miljic, P., DeSancho, M. T. & Teruya, J., 2022 Jul, In: Journal of Thrombosis and Haemostasis. 20, 7, p. 1735-1743 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A hydrophobic patch (PLVIVG; 1481–1486) in the B-domain of factor V-short is crucial for its synergistic TFPIα-cofactor activity with protein S and for the formation of the FXa-inhibitory complex comprising FV-short, TFPIα, and protein S

Dahlbäck, B. & Tran, S., 2022 May, In: Journal of Thrombosis and Haemostasis. 20, 5, p. 1146-1157 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults: A Population-Based Cohort Study

Manderstedt, E., Lind-Halldén, C., Halldén, C., Elf, J., Svensson, P. J., Dahlbäck, B., Engström, G., Melander, O., Baras, A., Lotta, L. A., Zöller, B. & Regeneron Genetics Center, 2022 Feb, In: Journal of the American Heart Association. 11, 4, e023018.

Research output: Contribution to journal › Article › peer-review

Open Access

The preAR2 region (1458–1492) in factor V-Short is crucial for the synergistic TFPIα-cofactor activity with protein S and the assembly of a trimolecular factor Xa-inhibitory complex comprising FV-Short, protein S, and TFPIα

Dahlbäck, B. & Tran, S., 2022 Jan, In: Journal of Thrombosis and Haemostasis. 20, 1, p. 58-68 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH

Brinkman, H. J. M., Ahnström, J., Castoldi, E., Dahlbäck, B. & Marlar, R. A., 2021, In: Journal of Thrombosis and Haemostasis. 19, 1, p. 281-286 6 p.

Research output: Contribution to journal › Article › peer-review

2020

Advances in understanding mechanisms of thrombophilic disorders

Dahlback, B., 2020, In: Hämostaseologie. 40, 1, p. 12-21 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Genetic risk factors for venous thromboembolism

Zöller, B., Svensson, P. J., Dahlbäck, B., Lind-Hallden, C., Hallden, C. & Elf, J., 2020, In: Expert Review of Hematology. 13, 9, p. 971-981

Research output: Contribution to journal › Review article › peer-review

Open Access

Reduced Apolipoprotein M and Adverse Outcomes across the Spectrum of Human Heart Failure

Chirinos, J. A., Zhao, L., Jia, Y., Frej, C., Adamo, L., Mann, D., Shewale, S. V., Millar, J. S., Rader, D. J., French, B., Brandimarto, J., Margulies, K. B., Parks, J. S., Wang, Z., Seiffert, D. A., Fang, J., Sweitzer, N., Chistoffersen, C., Dahlbäck, B. & Car, B. D. & 3 others, Gordon, D. A., Cappola, T. P. & Javaheri, A., 2020, In: Circulation. p. 1463-1476 14 p.

Research output: Contribution to journal › Article › peer-review

2019

Low plasma concentrations of apolipoprotein M are associated with disease activity and endothelial dysfunction in systemic lupus erythematosus

Tydén, H., Lood, C., Jönsen, A., Gullstrand, B., Kahn, R., Linge, P., Kumaraswamy, S. B., Dahlbäck, B. & Bengtsson, A. A., 2019 May 2, In: Arthritis Research and Therapy. 21, 1, 110.

Research output: Contribution to journal › Article › peer-review

Open Access

New functional test for the TFPIα cofactor activity of Protein S working in synergy with FV-Short

Dahlbäck, B., Guo, L. J., Zöller, B. & Tran, S., 2019, In: Journal of Thrombosis and Haemostasis. 17, 4, p. 585-595

Research output: Contribution to journal › Article › peer-review

Plasma Apolipoprotein M and Sphingosine-1-Phosphate Levels are Inversely Associated with Mortality in African Americans with Type 2 Diabetes Mellitus

Liu, M., Frej, C., Langefeld, C. D., Divers, J., Bowden, D. W., Carr, J., Gebre, A., Xu, J., Larsson, B., Dahlbäck, B., Freedman, B. I. & Parks, J. S., 2019, In: Journal of Lipid Research. 60, 8, p. 1425-1431

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Lean ApoM^−/−Mice with Hyperactive Brown Adipose Tissue

Dahlbäck, B., 2018 May, In: Trends in Endocrinology and Metabolism. 29, 5, p. 283-284

Research output: Contribution to journal › Article › peer-review

Evaluation of Expression Level of Apolipoprotein M as a Diagnostic Marker for Primary Venous Thromboembolism

Ahmad, A., Sundquist, K., Zöller, B., Dahlbäck, B., Elf, J., Svensson, P. J., Strandberg, K., Sundquist, J. & Memon, A. A., 2018 Apr, In: Clinical and Applied Thrombosis/Hemostasis. 24, 3, p. 416-422

Research output: Contribution to journal › Article › peer-review

Treating hemophilia by targeting protein S?

Dahlbäck, B., 2018 Mar 22, In: Blood. 131, 12, p. 1271-1272 2 p.

Research output: Contribution to journal › Debate/Note/Editorial › peer-review

Vitamin K–Dependent Protein S: Beyond the Protein C Pathway

Dahlbäck, B., 2018 Mar, In: Seminars in Thrombosis and Hemostasis. 44, 2, p. 176-184

Research output: Contribution to journal › Article › peer-review

High-density lipoprotein from end-stage renal disease patients exhibits superior cardioprotection and increase in sphingosine-1-phosphate

Brinck, J. W., Thomas, A., Brulhart-Meynet, M. C., Lauer, E., Frej, C., Dahlbäck, B., Stenvinkel, P., James, R. W. & Frias, M. A., 2018 Feb, In: European Journal of Clinical Investigation. 48, 2, e12866.

Research output: Contribution to journal › Article › peer-review

2017

Factor V-short and protein S as synergistic tissue factor pathway inhibitor (TFPIα) cofactors

Dahlbäck, B., Guo, L. J., Livaja Koshiar, R. & Tran, S., 2017 Dec 20, In: Research and practice in thrombosis and haemostasis. 2, 1, p. 114-124

Research output: Contribution to journal › Article › peer-review

Open Access

Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S

Dahlbäck, B., 2017 Jul 1, In: Journal of Thrombosis and Haemostasis. 15, 7, p. 1241-1250 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A Shift in ApoM/S1P between HDL-Particles in Women with Type 1 Diabetes Mellitus Is Associated with Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex

Frej, C., Mendez, A. J., Ruiz Garcia, M., Castillo, M., Hughes, T. A., Dahlbäck, B. & Goldberg, R. B., 2017 Jun 1, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 6, p. 1194-1205

Research output: Contribution to journal › Article › peer-review

Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier

Kober, A. C., Manavalan, A. P. C., Tam-Amersdorfer, C., Holmér, A., Saeed, A., Fanaee-Danesh, E., Zandl, M., Albrecher, N. M., Björkhem, I., Kostner, G. M., Dahlbäck, B. & Panzenboeck, U., 2017 Jun 1, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 6, p. 573-588 16 p.

Research output: Contribution to journal › Article › peer-review

The nanoparticle protein corona formed in human blood or human blood fractions

Lundqvist, M., Augustsson, C., Lilja, M., Lundkvist, K., Dahlbäck, B., Linse, S. & Cedervall, T., 2017 Apr 1, In: PLoS ONE. 12, 4, e0175871.

Research output: Contribution to journal › Article › peer-review

Open Access

HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

Ruiz Garcia, M., Okada, H. & Dahlbäck, B., 2017 Feb 8, In: Lipids in Health and Disease. 16, 1, 36.

Research output: Contribution to journal › Article › peer-review

Open Access

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1

Ruiz Garcia, M., Frej, C., Holmér, A., Guo, L. J., Tran, S. & Dahlbäck, B., 2017 Jan, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 1, p. 118-129

Research output: Contribution to journal › Article › peer-review

Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma

Grabiec, A. M., Denny, N., Doherty, J. A., Happonen, K. E., Hankinson, J., Connolly, E., Fife, M. E., Fujimori, T., Fujino, N., Goenka, A., Holden, S., Tavernier, G., Shah, R., Cook, P. C., MacDonald, A. S., Niven, R. M., Dahlbäck, B., Fowler, S. J., Simpson, A. & Hussell, T., 2017, In: Journal of Allergy and Clinical Immunology. 140, 4, p. 1144-1146.e4

Research output: Contribution to journal › Letter › peer-review

Open Access

Gas6-Axl signaling in presence of Sunitinib is enhanced, diversified and sustained in renal tumor cells, resulting in tumor-progressive advantages

Gustafsson, A., Fritz, H. K. M. & Dahlbäck, B., 2017, In: Experimental Cell Research. 355, 1, p. 47-56

Research output: Contribution to journal › Article › peer-review

2016

Identification of polymorphisms in Apolipoprotein M gene and their relationship with risk of recurrent venous thromboembolism

Ahmad, A., Sundquist, K., Zöller, B., Dahlbäck, B., Svensson, P. J., Sundquist, J. & Memon, A. A., 2016 Aug 30, In: Thrombosis and Haemostasis. 116, 3, p. 432-41 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Familial hypercholesterolaemia: cholesterol efflux and coronary disease

Versmissen, J., Vongpromek, R., Yahya, R., van der Net, J. B., van Vark-van der Zee, L., Blommesteijn-Touw, J., Wattimena, D., Rietveld, T., Pullinger, C. R., Christoffersen, C., Dahlbäck, B., Kane, J. P., Mulder, M. & Sijbrands, E. J. G., 2016 Jul 1, In: European Journal of Clinical Investigation. 46, 7, p. 643-650 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons

Frej, C., Linder, A., Happonen, K. E., Taylor, F. B., Lupu, F. & Dahlbäck, B., 2016 Jun 1, In: Journal of Cellular and Molecular Medicine. 20, 6, p. 1170-1181 12 p.

Research output: Contribution to journal › Article › peer-review

Pro- and anticoagulant properties of factor V in pathogenesis of thrombosis and bleeding disorders

Dahlbäck, B., 2016 May, In: International Journal of Laboratory Hematology. 38, p. 4-11

Research output: Contribution to journal › Article › peer-review

The Gas6-Axl Interaction Mediates Endothelial Uptake of Platelet Microparticles

Happonen, K. E., Tran, S., Mörgelin, M., Prince, R., Calzavarini, S., Angelillo-Scherrer, A. & Dahlbäck, B., 2016 Mar 22, In: Journal of Biological Chemistry. 291, 20, p. 10586-10601

Research output: Contribution to journal › Article › peer-review

Epidemiology of Familial Aggregation of Venous Thromboembolism

Zöller, B., Li, X., Ohlsson, H., Ji, J., Memon, A. A., Svensson, P. J., Palmér, K., Dahlbäck, B., Sundquist, J. & Sundquist, K., 2016, In: Seminars in Thrombosis and Hemostasis. 42, 8, p. 821-832

Research output: Contribution to journal › Review article › peer-review

Gas6 fueling tumor-mediated thrombosis.

Happonen, K. & Dahlbäck, B., 2016, In: Blood. 127, 6, p. 672-673

Research output: Contribution to journal › Article › peer-review

Urinary apolipoprotein M as a biomarker of acute kidney injury in children undergoing heart surgery.

Madsen Svarrer, E. M., Andersen, H. Ø., Helvind, M., Slagman, M. C., Navis, G., Dullaart, R. P., Dahlbäck, B. & Nielsen, L. B., 2016, In: Biomarkers in Medicine. 10, 1, p. 81-93

Research output: Contribution to journal › Article › peer-review

2015

Amino acid residues in the laminin G domains of protein S involved in tissue factor pathway inhibitor interaction.

Somajo, S., Ahnström, J., Fernandez-Recio, J., Gierula, M., Villoutreix, B. O. & Dahlbäck, B., 2015, In: Thrombosis and Haemostasis. 113, 5, p. 976-987

Research output: Contribution to journal › Article › peer-review

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

Galvani, S., Sanson, M., Blaho, V. A., Swendeman, S. L., Conger, H., Dahlbäck, B., Kono, M., Proia, R. L., Smith, J. D. & Hla, T., 2015, In: Science Signaling. 8, 389, p. ra79

Research output: Contribution to journal › Article › peer-review

Protein Unfolding allow use of Commercial Antibodies in an Apolipoprotein M sandwich ELISA.

Bosteen, M. H., Dahlbäck, B., Nielsen, L. B. & Christoffersen, C., 2015, In: Journal of Lipid Research. 56, 3, p. 754-759

Research output: Contribution to journal › Article › peer-review

Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation.

Frej, C., Andersson, A. S., Larsson, B., Guo, L. J., Norström, E., Happonen, K. & Dahlbäck, B., 2015, In: Analytical and Bioanalytical Chemistry. 407, 28, p. 8533-8542

Research output: Contribution to journal › Article › peer-review

Open Access

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Fritz, H., Gustafsson, A., Ljungberg, B., Ceder, Y., Axelson, H. & Dahlbäck, B., 2015, In: PLoS ONE. 10, 8, e0135991.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

Apolipoprotein M and the risk of unprovoked recurrent venous thromboembolism.

Memon, A., Sundquist, J., Zöller, B., Wang, X., Dahlbäck, B., Svensson, P. & Sundquist, K., 2014, In: Thrombosis Research. 133, 3, p. 322-326

Research output: Contribution to journal › Article › peer-review

Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation.

Livaja Koshiar, R., Somajo, S., Norström, E. & Dahlbäck, B., 2014, In: PLoS ONE. 9, 8, e104200.

Research output: Contribution to journal › Article › peer-review

Open Access

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185 Downloads (Pure)

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The miR(21/10b) ratio as a prognostic marker in clear cell renal cell carcinoma.

Fritz, H., Lindgren, D., Ljungberg, B., Axelson, H. & Dahlbäck, B., 2014, In: European Journal of Cancer. 50, 10, p. 1758-1765

Research output: Contribution to journal › Article › peer-review

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228 Downloads (Pure)

2013

Coagulation factor V-A2440G causes east Texas bleeding disorder via TFPI alpha

Vincent, L. M., Tran, S., Livaja Koshiar, R., Bensend, T. A., Milewicz, D. M. & Dahlbäck, B., 2013, In: Journal of Clinical Investigation. 123, 9, p. 3777-3787

Research output: Contribution to journal › Article › peer-review

Open Access

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Björn Dahlbäck

Research output

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