The Consiglio Lab investigates how biological sex impacts human immunity using systems immunology approaches. Generally, females mount more robust immune responses than males, resulting in lower severity of infections, decreased frequency of cancer, but increased prevalence of autoimmunity. Yet, we do not fully understand the precise mechanisms that underlie such sex discrepancies.

Our lab combines high throughput multiomics technologies with state-of-the-art computational methods to understand mechanisms of sex differences in human immunity. Our major research focus are centered around:

1. Immunomonitoring of human cohorts using systems immunology: Here we investigate the emergence and drivers of sex differences in the human immune system throughout life periods. We do this by collecting longitudinal samples of human cohorts at different stages of their life, and applying multiomics techniques and computational methods to understand sex and sex hormone modulation of human immunity.

2. Mechanistic investigation of sex hormone modulation of the human immune system: Sex hormones have clear effects on immune cells; yet, we do not fully understand what immune genes, pathways and responses are modulated by sex hormones in humans. This project is dives into mechanisms of sex hormone modulation of immune function in humans.

Camila Consiglio is a DDLS (Data-driven life sciences) fellow. DDLS is a program that is funded by SciLifeLab and The Wallenberg National Program (https://www.scilifelab.se/data-driven/ ).