Caroline Sandén

2023

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

Strickson, S., Houslay, K. F., Negri, V. A., Ohne, Y., Ottosson, T., Dodd, R. B., Huntington, C. C., Baker, T., Li, J., Stephenson, K. E., O’Connor, A. J., Sagawe, J. S., Killick, H., Moore, T., Rees, D. G., Koch, S., Sanden, C., Wang, Y., Gubbins, E. & Ghaedi, M. & 8 others, Kolbeck, R., Saumyaa, S., Erjefält, J. S., Sims, G. P., Humbles, A. A., Scott, I. C., Ros, X. R. & Cohen, E. S., 2023 Sept 1, In: European Respiratory Journal. 62, 3, 2202210.

Research output: Contribution to journal › Article › peer-review

Open Access

Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes

Hvidtfeldt, M., Sverrild, A., Pulga, A., Frøssing, L., Silberbrandt, A., Hostrup, M., Thomassen, M., Sanden, C., Clausson, C. M., Siddhuraj, P., Bornesund, D., Nieto-Fontarigo, J. J., Uller, L., Erjefält, J. & Porsbjerg, C., 2023, In: Journal of Allergy and Clinical Immunology. 152, 1, p. 107-116.e4

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19

Erjefält, J. S., de Souza Xavier Costa, N., Jönsson, J., Cozzolino, O., Dantas, K. C., Clausson, C. M., Siddhuraj, P., Lindö, C., Alyamani, M., Lombardi, S. C. F. S., Mendroni Júnior, A., Antonangelo, L., Faria, C. S., Duarte-Neto, A. N., de Almeida Monteiro, R. A., Rebello Pinho, J. R., Gomes-Gouvêa, M. S., Verciano Pereira, R., Monteiro, J. S. & Setubal, J. C. & 9 others, de Oliveira, E. P., Theodoro Filho, J., Sanden, C., Orengo, J. M., Sleeman, M. A., da Silva, L. F. F., Saldiva, P. H. N., Dolhnikoff, M. & Mauad, T., 2022 Sept, In: EBioMedicine. 83, 104229.

Research output: Contribution to journal › Article › peer-review

Open Access

Mucosal cryobiopsies: a new method for studying airway pathology in asthma

Hvidtfeldt, M., Sverrild, A., Pulga, A., Frøssing, L., Silberbrandt, A., Sanden, C., Clausson, C. M., Bornesund, D., Erjefält, J. & Porsbjerg, C., 2022, In: ERJ open research. 8, 1, 00666-2021.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma

Lamb, D., De Sousa, D., Quast, K., Fundel-Clemens, K., Erjefält, J. S., Sandén, C., Hoffmann, H. J., Kästle, M., Schmid, R., Menden, K. & Delic, D., 2021 Dec 1, In: Respiratory Research. 22, 1, 158.

Research output: Contribution to journal › Article › peer-review

Open Access

Lung Mast Cells Have a High Constitutive Expression of Carboxypeptidase A3 mRNA That Is Independent from Granule-Stored CPA3

Siddhuraj, P., Clausson, C. M., Sanden, C., Alyamani, M., Kadivar, M., Marsal, J., Wallengren, J., Bjermer, L. & Erjefält, J. S., 2021, In: Cells. 10, 2

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Eosinophils, basophils, and type 2 immune microenvironments in COPD-affected lung tissue

Jogdand, P., Siddhuraj, P., Mori, M., Sanden, C., Jönsson, J., Walls, A. F., Kearley, J., Humbles, A. A., Kolbeck, R., Bjermer, L., Newbold, P. & Erjefält, J. S., 2020, In: European Respiratory Journal. 55, 4

Research output: Contribution to journal › Article › peer-review

Open Access

2019

IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation

Allinne, J., Scott, G., Lim, W. K., Birchard, D., Erjefält, J. S., Sandén, C., Ben, L. H., Agrawal, A., Kaur, N., Kim, J. H., Kamat, V., Fury, W., Huang, T., Stahl, N., Yancopoulos, G. D., Murphy, A. J., Sleeman, M. A. & Orengo, J. M., 2019 Dec, In: Journal of Allergy and Clinical Immunology. 144, 6, p. 1624-1637 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Human G protein-coupled Receptor 30 (GPR30) is N -glycosylated and N-terminal Domain Asparagine 44 is Required for Receptor Structure and Activity

Gonzalez de Valdivia, E., Sandén, C., Kahn, R., Olde, B. & Leeb-Lundberg, F. L. M., 2019 Feb 13, In: Bioscience Reports. 39, 2, BSR20182436.

Research output: Contribution to journal › Article › peer-review

Bronchoscopic mucosal cryobiopsies as a method for studying airway disease

Hvidtfeldt, M., Pulga, A., Hostrup, M., Sanden, C., Mori, M., Bornesund, D., Larsen, K. R., Erjefält, J. S. & Porsbjerg, C., 2019 Jan, In: Clinical and Experimental Allergy. 49, 1, p. 27-34

Research output: Contribution to journal › Article › peer-review

2018

Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

Scott, I. C., Majithiya, J. B., Sanden, C., Thornton, P., Sanders, P. N., Moore, T., Guscott, M., Corkill, D. J., Erjefält, J. S. & Cohen, E. S., 2018 Dec 1, In: Scientific Reports. 8, 1, 3363.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis

Sanden, C., Mori, M., Jogdand, P., Jönsson, J., Krishnan, R., Wang, X. & Erjefält, J. S., 2017, In: Immunity, Inflammation and Disease. 5, 3, p. 300-309

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

Silver, J. S., Kearley, J., Copenhaver, A. M., Sanden, C., Mori, M., Yu, L., Pritchard, G. H., Berlin, A. A., Hunter, C. A., Bowler, R., Erjefält, J., Kolbeck, R. & Humbles, A. A., 2016, In: Nature Immunology. 17, 6, p. 626-635

Research output: Contribution to journal › Article › peer-review

Open Access

Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours

Braekeveldt, N., Wigerup, C., Tadeo, I., Beckman, S., Sandén, C., Jönsson, J., Erjefält, J. S., Berbegall, A. P., Börjesson, A., Backman, T., Øra, I., Navarro, S., Noguera, R., Gisselsson, D., Påhlman, S. & Bexell, D., 2016, In: Cancer Letters. 375, 2, p. 384-389

Research output: Contribution to journal › Article › peer-review

Open Access

2015

A major population of mucosal memory CD4(+) T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.

Holmkvist, P., Roepstorff, K., Uronen-Hansson, H., Sandén, C., Gudjonsson, S., Hultman Patschan, O., Grip, O., Marsal, J., Schmidtchen, A., Hornum, L., Erjefält, J., Håkansson, K. & Agace, W., 2015, In: Mucosal Immunology. 8, 3, p. 545-558

Research output: Contribution to journal › Article › peer-review

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203 Downloads (Pure)

Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.

Kearley, J., Silver, J. S., Sandén, C., Liu, Z., Berlin, A. A., White, N., Mori, M., Pham, T.-H., Ward, C. K., Criner, G. J., Marchetti, N., Mustelin, T., Erjefält, J., Kolbeck, R. & Humbles, A. A., 2015, In: Immunity. 42, 3, p. 566-579

Research output: Contribution to journal › Article › peer-review

IL-17A is Elevated in End-stage COPD and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis.

Roos, A., Sandén, C., Mori, M., Bjermer, L., Stampfli, M. R. & Erjefält, J., 2015, In: American Journal of Respiratory and Critical Care Medicine. 191, 11, p. 1232-1241

Research output: Contribution to journal › Article › peer-review

Interleukin-17A Promotes Neutrophilia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Roos, A., Sethi, S., Nikota, J., Wrona, C. T., Dorrington, M. G., Sandén, C., Bauer, C. M., Shen, P., Bowdish, D., Stevenson, C. S., Erjefält, J. & Stampfli, M. R., 2015, In: American Journal of Respiratory and Critical Care Medicine. 192, 4, p. 428-437

Research output: Contribution to journal › Article › peer-review

2014

Kinin-Stimulated B1 Receptor Signaling Depends on Receptor Endocytosis Whereas B2 Receptor Signaling Does Not.

Enquist, J., Sandén, C., Skröder, C., Mathis, S. A. & Leeb-Lundberg, F., 2014, In: Neurochemical Research. 39, 6, p. 1037-1047

Research output: Contribution to journal › Article › peer-review

2013

Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface.

Sandén, C. & Leeb-Lundberg, F., 2013, In: International Immunopharmacology. 15, 1, p. 121-128

Research output: Contribution to journal › Article › peer-review

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385 Downloads (Pure)

2011

G Protein-Coupled Estrogen Receptor 1 (GPER1)/GPR30 Localizes in the Plasma Membrane and Trafficks Intracellularly on Cytokeratin Intermediate Filaments.

Sandén, C., Broselid, S., Cornmark, L., Andersson, K., Daszkiewicz-Nilsson, J., Mårtensson, U., Olde, B. & Leeb-Lundberg, F., 2011, In: Molecular Pharmacology. 79, 3, p. 400-410

Research output: Contribution to journal › Article › peer-review

2009

Activation of TAFI on the Surface of Streptococcus pyogenes Evokes Inflammatory Reactions by Modulating the Kallikrein/Kinin System

Bengtson, S., Sandén, C., Mörgelin, M., Marx, P., Olin, A., Leeb-Lundberg, F., Meijers, J. C. M. & Herwald, H., 2009, In: Journal of Innate Immunity. 1, 1, p. 18-28

Research output: Contribution to journal › Article › peer-review

G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

Sandén, C., 2009, Experimentel medicinsk vetenskap, Lunds Universitet. 155 p.

Research output: Thesis › Doctoral Thesis (compilation)

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807 Downloads (Pure)

2008

Kinin B2 Receptor-Mediated Bradykinin Internalization and Metalloendopeptidase EP24.15-Dependent Intracellular Bradykinin Degradation.

Sandén, C., Enquist, J., Bengtson, S., Herwald, H. & Leeb-Lundberg, F., 2008, In: Journal of Pharmacology and Experimental Therapeutics. 326, 1, p. 24-32

Research output: Contribution to journal › Article › peer-review

Caroline Sandén

Research output

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