Cecilia Hegardt

2022

How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? A Study of Paired Core-Needle Biopsies and Surgical Specimens in Early Breast Cancer

Saghir, H., Veerla, S., Malmberg, M., Rydén, L., Ehinger, A., Saal, L. H., Vallon-Christersson, J., Borg, Å., Hegardt, C., Larsson, C., Haidar, A., Hedenfalk, I., Loman, N. & Kimbung, S., 2022 Aug 18, In: Cancers. 14, 16, p. 1-16 4000.

Research output: Contribution to journal › Article › peer-review

Open Access

One-year recovery from breast cancer: Importance of tumor and treatment-related factors, resilience, and sociodemographic factors for health-related quality of life

Veličković, K., Borrebaeck, C. A. K., Bendahl, P. O., Hegardt, C., Johnsson, P., Richter, C., Rydén, L. & Hallberg, I. R., 2022 Aug 16, In: Frontiers in Oncology. 12, 891850.

Research output: Contribution to journal › Article › peer-review

Open Access

RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer

Staaf, J., Häkkinen, J., Hegardt, C., Saal, L. H., Kimbung, S., Hedenfalk, I., Lien, T., Sørlie, T., Naume, B., Russnes, H., Marcone, R., Ayyanan, A., Brisken, C., Malterling, R. R., Asking, B., Olofsson, H., Lindman, H., Bendahl, P.-O., Ehinger, A. & Larsson, C. & 5 others, Loman, N., Rydén, L., Malmberg, M., Borg, Å. & Vallon-Christersson, J., 2022 Aug 16, In: npj Breast Cancer. 8, p. 1-17 94.

Research output: Contribution to journal › Article › peer-review

Open Access

RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer

Vallon-Christersson, J., Staaf, J., Häkkinen, J., Hegardt, C., Saal, L., Ehinger, A., Larsson, C., Loman, N., Rydén, L., Malmberg, M. & Borg, Å., 2022 May 1, In: Annals of Oncology. 33, Suppl 3, p. S144-S145 52P.

Research output: Contribution to journal › Published meeting abstract › peer-review

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2021

Psychological resilience and health‐related quality of life in 418 swedish women with primary breast cancer: Results from a prospective longitudinal study

Mohlin, Å., Bendahl, P. O., Hegardt, C., Richter, C., Hallberg, I. R. & Rydén, L., 2021 May 1, In: Cancers. 13, 9, 2233.

Research output: Contribution to journal › Article › peer-review

Open Access

Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer

Dahlgren, M., George, A., Brueffer, C., Gladchuk, S., Chen, Y., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Ryden, L., Malmberg, M., Larsson, C., Gruvberger, S., Ehinger, A., Loman, N., Borg, Å. & Saal, L., 2021 Apr 22, In: JNCI Cancer Spectrum. 5, 2, pkab028.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of Extracellular Matrix Proteins Secreted by Human Dermal Fibroblasts Cultured in 3D Electrospun Scaffolds

Malakpour Permlid, A., Buzzi, I., Hegardt, C., Johansson, F. & Oredsson, S., 2021 Mar 23, In: Scientific Reports. 11, 18 p., 6655.

Research output: Contribution to journal › Article › peer-review

Open Access

“Association of mammographic features with molecular breast tumor profiles”

Sartor, H., Zackrisson, S., Hegardt, C. & Larsson, C., 2021, In: Cancer Treatment and Research Communications. 28, 100387.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

The mutational landscape of the SCAN‐B real‐world primary breast cancer transcriptome

Brueffer, C., Gladchuk, S., Winter, C., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., George, A., Chen, Y., Ehinger, A., Larsson, C., Loman, N., Malmberg, M., Ryden, L., Borg, Å. & Saal, L., 2020 Sept 14, In: EMBO Molecular Medicine. 12, 10, e12118.

Research output: Contribution to journal › Article › peer-review

Open Access

Abstract CT074: Pre-existing ESR1 mutations in early-stage primary breast cancer predict failure of endocrine therapy and poor survival

Dahlgren, M., George, A., Brueffer, C., Gladchuk, S., Chen, Y., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Ryden, L., Malmberg, M., Larsson, C., Gruvberger, S., Ehinger, A., Loman, N., Borg, Å. & Saal, L., 2020 Aug, In: Cancer research. Supplement. 80, 16

Research output: Contribution to journal › Published meeting abstract

Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer

Larsson, C., Ehinger, A., Winslow, S., Leandersson, K., Klintman, M., Dahl, L., Vallon-christersson, J., Häkkinen, J., Hegardt, C., Manjer, J., Saal, L., Rydén, L., Malmberg, M., Borg, Å. & Loman, N., 2020 Jul 6, In: npj Breast Cancer. 6, 1, 28.

Research output: Contribution to journal › Article › peer-review

Open Access

Defining the mutational landscape of 3,217 primary breast cancer transcriptomes through large-scale RNA-seq within the Sweden Cancerome Analysis Network: Breast Project (SCAN-B; NCT03430492).

Brueffer, C., Gladchuk, S., Winter, C., Vallon-christersson, J., Hegardt, C., Häkkinen, J., George, A. M., Chen, Y., Ehinger, A., Larsson, C., Loman, N., Malmberg, M., Rydén, L., Borg, Å. & Saal, L. H., 2020 May 20, In: Journal of Clinical Oncology. 38, 15_suppl, p. 518-518

Research output: Contribution to journal › Published meeting abstract

Whole-genome sequencing of triple negative breast cancers in a standard population-based clinical setting

Staaf, J., Glodzik, D., Bosch Campos, A., Vallon-Christersson, J., Reuterswärd, C., Häkkinen, J., Degasperi, A., Amarante, T. D., Saal, L., Hegardt, C., Stobart, H., Ehinger, A., Larsson, C., Ryden, L., Loman, N., Malmberg, M., Kvist, A., Ehrencrona, H., Davies, H. R. & Borg, Å. & 1 others, Nik-Zainal, S., 2020 Feb 6, In: Breast Cancer Research and Treatment. 180, p. 531-532

Research output: Contribution to journal › Published meeting abstract

Abstract P1-18-10: Preoperative treatment of HER2-positive breast cancer in South Sweden. A retrospective, comprehensive survey of neo-adjuvant treated HER2-positve breast cancer in the SCAN-B project 2010-2017

Malmberg, M., Larsson, C., Vallon-Christersson, J., Ehinger, A., Hegardt, C., Killander, F., Ryden, L., Saal, L., Loman, N. & Borg, Å., 2020 Feb, In: Cancer research. Supplement. 80, Issue 4 Supplement, p. P1-18-10

Research output: Contribution to journal › Published meeting abstract

The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome

Brueffer, C., Gladchuk, S., Winter, C., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., George, A., Chen, Y., Ehinger, A., Larsson, C., Loman, N., Malmberg, M., Ryden, L., Borg, Å. & Saal, L., 2020 Jan 31, bioRxiv.

Research output: Working paper/Preprint › Preprint (in preprint archive)

Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers

Glodzik, D., Bosch, A., Hartman, J., Aine, M., Vallon-Christersson, J., Reuterswärd, C., Karlsson, A., Mitra, S., Niméus, E., Holm, K., Häkkinen, J., Hegardt, C., Saal, L. H., Larsson, C., Malmberg, M., Rydén, L., Ehinger, A., Loman, N., Kvist, A. & Ehrencrona, H. & 3 others, Nik-zainal, S., Borg, Å. & Staaf, J., 2020, In: Nature Communications. 11, 1, 3747.

Research output: Contribution to journal › Article › peer-review

Open Access

Psychological resilience and health-related quality of life in Swedish women with newly diagnosed breast cancer

Mohlin, Å., Axelsson, U., Bendahl, P. O., Borrebaeck, C., Hegardt, C., Johnsson, P., Hallberg, I. R. & Rydén, L., 2020, In: Cancer Management and Research. 12, p. 12041-12051 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series

Vallon-Christersson, J., Häkkinen, J., Hegardt, C., Saal, L., Larsson, C., Ehinger, A., Lindman, H., Olofsson, H., Sjoblom, T., Wärnberg, F., Rydén, L., Loman, N., Malmberg, M., Borg, Å. & Staaf, J., 2019 Aug 21, In: Scientific Reports. 9, 12184.

Research output: Contribution to journal › Article › peer-review

Open Access

Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer

Lundgren, C., Bendahl, P.-O., Ehinger, A., Hegardt, C., Larsson, C., Loman, N., Malmberg, M., Olofsson, H., Saal, L., Sjoblom, T., Lindman, H., Klintman, M., Häkkinen, J., Vallon-Christersson, J., Fernö, M., Rydén, L. & Ekholm, M., 2019 Aug 20, In: Breast Cancer Research and Treatment. p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Prediction of lymph node metastasis in breast cancer by gene expression and clinicopathological models: Development and validation within a population based cohort.

Dihge, L., Vallon-Christersson, J., Hegardt, C., Saal, L., Häkkinen, J., Larsson, C., Ehinger, A., Loman, N., Malmberg, M., Bendahl, P.-O., Borg, Å., Staaf, J. & Rydén, L., 2019 Jul 24, In: Clinical Cancer Research. 25, 21, p. 6368-6381

Research output: Contribution to journal › Article › peer-review

Refinement of breast cancer molecular classification by miRNA expression profiles

Søkilde, R., Persson, H., Ehinger, A., Pirona, A. C., Fernö, M., Hegardt, C., Larsson, C., Loman, N., Malmberg, M., Rydén, L., Saal, L., Borg, Å., Vallon-Christerson, J. & Rovira, C., 2019 Jun 17, In: BMC Genomics. 20, 1, 12 p., 503.

Research output: Contribution to journal › Article › peer-review

Open Access

Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study

Staaf, J., Glodzik, D., Bosch, A., Vallon-Christersson, J., Reuterswärd, C., Häkkinen, J., Degasperi, A., Amarante, T. D., Saal, L. H., Hegardt, C., Stobart, H., Ehinger, A., Larsson, C., Rydén, L., Loman, N., Malmberg, M., Kvist, A., Ehrencrona, H., Davies, H. R. & Borg, Å. & 1 others, Nik-Zainal, S., 2019, In: Nature Medicine. 25, p. 1526–1533

Research output: Contribution to journal › Article › peer-review

2018

The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin

Huang, X., Borgström, B., Stegmayr, J., Abassi, Y., Kruszyk, M., Leffler, H., Persson, L., Albinsson, S., Massoumi, R., Scheblykin, I. G., Hegardt, C., Oredsson, S. & Strand, D., 2018 Jun 27, In: ACS Central Science. 4, 6, p. 760-767 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative

Brueffer, C., Vallon-Christersson, J., Grabau, D., Ehinger, A., Häkkinen, J., Hegardt, C., Malina, J., Chen, Y., Bendahl, P.-O., Manjer, J., Malmberg, M., Larsson, C., Loman, N., Rydén, L., Borg, Å. & Saal, L. H., 2018 Mar 9, In: JCO Precision Oncology. 2, p. 1-18

Research output: Contribution to journal › Article › peer-review

Open Access

Abstract P1-06-01: Putting multigene signatures to the test: Prognostic assessment in population-based contemporary clinical breast cancer

Staaf, J., Vallon-Christersson, J., Häkkinen, J., Saal, L., Hegardt, C., Larsson, C., Ehinger, A., Rydén, L., Loman, N., Malmberg, M. & Borg, Å., 2018 Feb, In: Cancer research. Supplement. 78, 4

Research output: Contribution to journal › Published meeting abstract › peer-review

Open Access

Abstract P2-02-09: Breast cancer subtype distribution and circulating tumor DNA in response to neoadjuvant chemotherapy: Experiences from a preoperative cohort within SCAN-B

Loman, N., Chen, Y., Aaltonen, K., Brueffer, C., George, A., Zander, L., Vallon-Christersson, J., Häkkinen, J., Förnvik, D., Rigo, R., Ehinger, A., Malmberg, M., Larsson, C., Hegardt, C., Borg, Å., Rydén, L. & Saal, L., 2018 Feb, In: Cancer research. Supplement. 78, 4

Research output: Contribution to journal › Published meeting abstract › peer-review

Open Access

Abstract P3-02-02: Concordance between immunohistochemical and gene-expression based subtyping of early breast cancer using core needle biopsies and surgical specimens - experices from SCAN-B

Morgan, G., Larsson, C., Tahin, B., Vallon-Christersson, J., Häkkinen, J., Ehinger, A., Malmberg, M., Hegardt, C., Borg, Å., Rydén, L., Saal, L., Hedenfalk, I. & Loman, N., 2018 Feb, In: Cancer research. Supplement. 78, 4

Research output: Contribution to journal › Published meeting abstract › peer-review

Open Access

Abstract P4-09-03: On the development and clinical value of RNA-sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter SCAN-B study

Brueffer, C., Vallon-Christersson, J., Grabau, D., Ehinger, A., Häkkinen, J., Hegardt, C., Malina, J., Chen, Y., Bendahl, P.-O., Manjer, J., Malmberg, M., Larsson, C., Loman, N., Rydén, L., Borg, Å. & Saal, L., 2018 Feb, In: Cancer research. Supplement. 78, 4

Research output: Contribution to journal › Published meeting abstract › peer-review

Open Access

Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative

Rydén, L., Loman, N., Larsson, C., Hegardt, C., Vallon-Christersson, J., Malmberg, M., Lindman, H., Ehinger, A., Saal, L. H. & Borg, Å., 2018 Jan 17, In: British Journal of Surgery. 105, 2, p. e158–e168

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Myoepithelium assessment with p63 immunostaining in formalinfixed paraffin-embedded breast cancer tissue pre-treated with RNA-later

Ehinger, A., Remse, I., Lövgren, K., Hegardt, C., Häkkinen, J., Saal, L., Vallon-Christersson, J. & Borg, Å., 2017 Sept 2, In: Virchows Archiv. 471, Supplement 1, p. 299 1 p., E-PS-02-027.

Research output: Contribution to journal › Published meeting abstract › peer-review

Open Access

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Structure–Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Selectivity of Semi-synthetic Derivatives

Borgström, B., Huang, X., Hegardt, C., Oredsson, S. & Strand, D., 2017 Feb 10, In: Chemistry - A European Journal. 23, 9, p. 2077-2083 7 p.

Research output: Contribution to journal › Article › peer-review

Abstract P1-07-17: The SCAN-B study: 5-year summary of a large-scale population-based prospective breast cancer translational genomics platform covering a wide geography of Sweden (NCT02306096)

Saal, L., Hegardt, C., Vallon-Christersson, J., Häkkinen, J., Ehinger, A., Manjer, J., Larsson, C., Loman, N., Rydén, L., Malmberg, M. & Borg, Å., 2017 Feb, In: Cancer Research. 77, 4 Suppl

Research output: Contribution to journal › Published meeting abstract › peer-review

2016

Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic

Winter, C., Nilsson, M. P., Olsson, E., George, A. M., Chen, Y., Kvist, A., Törngren, T., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Jönsson, G., Grabau, D., Malmberg, M., Kristoffersson, U., Rehn, M., Gruvberger-Saal, S. K., Larsson, C., Borg, Å., Loman, N. & Saal, L. H., 2016 Aug, In: Annals of Oncology. 27, 8, p. 1532-8 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs.

Huang, X., Borgström, B., Kempengren, S., Persson, L., Hegardt, C., Strand, D. & Oredsson, S., 2016, In: BMC Cancer. 16, 1, 145.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.

Sjöström, M., Werner Hartman, L., Honeth, G., Grabau, D., Malmström, P., Hegardt, C., Fernö, M. & Niméus, E., 2015, In: Journal of Clinical Pathology. 68, 12, p. 1012-1019

Research output: Contribution to journal › Article › peer-review

The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine.

Saal, L., Vallon-Christersson, J., Häkkinen, J., Hegardt, C., Grabau, D., Winter, C., Brueffer, C., Tang, M.-H. E., Reuterswärd, C., Schulz, R., Karlsson, A. K., Ehinger, A., Malina, J., Manjer, J., Malmberg, M., Larsson, C., Rydén, L., Loman, N. & Borg, Å., 2015, In: Genome Medicine. 7, 1, 20.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

Semisynthesis of SY-1 for Investigation of Breast Cancer Stem Cell Selectivity of C-Ring-Modified Salinomycin Analogues.

Huang, X., Borgström, B., Månsson, L., Persson, L., Oredsson, S., Hegardt, C. & Strand, D., 2014, In: ACS Chemical Biology. 9, 7, p. 1587-1594

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Synthetic modification of salinomycin: selective O-acylation and biological evaluation

Borgström, B., Huang, X., Posta, M., Hegardt, C., Oredsson, S. & Strand, D., 2013, In: Chemical Communications. 49, 85, p. 9944-9946 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours.

Holm, K., Staaf, J., Jönsson, G. B., Vallon-Christersson, J., Gunnarsson, H., Arason, A., Magnusson, L., Barkardottir, R. B., Hegardt, C., Ringnér, M. & Borg, Å., 2012, In: Breast Cancer Research and Treatment. 133, 2, p. 583-594

Research output: Contribution to journal › Article › peer-review

Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes.

Holm, K., Grabau, D., Lövgren, K., Aradottir, S., Gruvberger, S., Howlin, J., Saal, L., Ethier, S. P., Bendahl, P.-O., Stål, O., Malmström, P., Fernö, M., Rydén, L., Hegardt, C., Borg, Å. & Ringnér, M., 2012, In: Molecular Oncology. 6, 5, p. 494-506

Research output: Contribution to journal › Article › peer-review

Open Access

The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer.

Jönsson, G. B., Staaf, J., Vallon-Christersson, J., Ringnér, M., Gruvberger, S., Saal, L., Holm, K., Hegardt, C., Arason, A., Fagerholm, R., Olsson, C., Grabau, D., Johnsson, E., Lövgren, K., Magnusson, L., Heikkilä, P., Agnarsson, B. A., Johannsson, O. T., Malmström, P. & Fernö, M. & 5 others, Olsson, H., Loman, N., Nevanlinna, H., Barkardottir, R. B. & Borg, Å., 2012, In: Cancer Research. 72, 16, p. 4028-4036

Research output: Contribution to journal › Article › peer-review

2011

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers.

Olsson, E., Honeth, G., Bendahl, P.-O., Saal, L., Gruvberger, S., Ringnér, M., Vallon-Christersson, J., Jönsson, G. B., Holm, K., Lövgren, K., Fernö, M., Grabau, D., Borg, Å. & Hegardt, C., 2011, In: BMC Cancer. 11, 418.

Research output: Contribution to journal › Article › peer-review

Open Access

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The antiproliferative effect of dietary fibre phenolic compounds ferulic acid and p-coumaric acid on the cell cycle in Caco-2 cells

Janicke, B., Hegardt, C., Krogh, M., Önning, G., Åkesson, B., Cirenajwis, H. & Oredsson, S., 2011, In: Nutrition and Cancer. 63, p. 611-622 12 p.

Research output: Contribution to journal › Article › peer-review

2010

Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

Jönsson, G. B., Staaf, J., Vallon-Christersson, J., Ringnér, M., Holm, K., Hegardt, C., Gunnarsson, H., Fagerholm, R., Forsare, C., Agnarsson, B. A., Kilpivaara, O., Luts, L., Heikkila, P., Aittomaki, K., Blomqvist, C., Loman, N., Malmström, P., Olsson, H., Johannsson, O. T. & Arason, A. & 3 others, Nevanlinna, H., Barkardottir, R. B. & Borg, Å., 2010, In: Breast Cancer Research. 12, 3, R42.

Research output: Contribution to journal › Article › peer-review

Open Access

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