Research output per year
Research output per year
Research output
- 47 results
Search results
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2022
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? A Study of Paired Core-Needle Biopsies and Surgical Specimens in Early Breast Cancer
Saghir, H., Veerla, S., Malmberg, M., Rydén, L., Ehinger, A., Saal, L. H., Vallon-Christersson, J., Borg, Å., Hegardt, C., Larsson, C., Haidar, A., Hedenfalk, I., Loman, N. & Kimbung, S., 2022 Aug 18, In: Cancers. 14, 16, p. 1-16 4000.Research output: Contribution to journal › Article › peer-review
Open Access -
One-year recovery from breast cancer: Importance of tumor and treatment-related factors, resilience, and sociodemographic factors for health-related quality of life
Veličković, K., Borrebaeck, C. A. K., Bendahl, P. O., Hegardt, C., Johnsson, P., Richter, C., Rydén, L. & Hallberg, I. R., 2022 Aug 16, In: Frontiers in Oncology. 12, 891850.Research output: Contribution to journal › Article › peer-review
Open Access -
RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
Staaf, J., Häkkinen, J., Hegardt, C., Saal, L. H., Kimbung, S., Hedenfalk, I., Lien, T., Sørlie, T., Naume, B., Russnes, H., Marcone, R., Ayyanan, A., Brisken, C., Malterling, R. R., Asking, B., Olofsson, H., Lindman, H., Bendahl, P.-O., Ehinger, A. & Larsson, C. & 5 others, , 2022 Aug 16, In: npj Breast Cancer. 8, p. 1-17 94.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Psychological resilience and health‐related quality of life in 418 swedish women with primary breast cancer: Results from a prospective longitudinal study
Mohlin, Å., Bendahl, P. O., Hegardt, C., Richter, C., Hallberg, I. R. & Rydén, L., 2021 May 1, In: Cancers. 13, 9, 2233.Research output: Contribution to journal › Article › peer-review
Open Access -
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer
Dahlgren, M., George, A., Brueffer, C., Gladchuk, S., Chen, Y., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Ryden, L., Malmberg, M., Larsson, C., Gruvberger, S., Ehinger, A., Loman, N., Borg, Å. & Saal, L., 2021 Apr 22, In: JNCI Cancer Spectrum. 5, 2, pkab028.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of Extracellular Matrix Proteins Secreted by Human Dermal Fibroblasts Cultured in 3D Electrospun Scaffolds
Malakpour Permlid, A., Buzzi, I., Hegardt, C., Johansson, F. & Oredsson, S., 2021 Mar 23, In: Scientific Reports. 11, 18 p., 6655.Research output: Contribution to journal › Article › peer-review
Open Access -
“Association of mammographic features with molecular breast tumor profiles”
Sartor, H., Zackrisson, S., Hegardt, C. & Larsson, C., 2021, In: Cancer Treatment and Research Communications. 28, 100387.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
The mutational landscape of the SCAN‐B real‐world primary breast cancer transcriptome
Brueffer, C., Gladchuk, S., Winter, C., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., George, A., Chen, Y., Ehinger, A., Larsson, C., Loman, N., Malmberg, M., Ryden, L., Borg, Å. & Saal, L., 2020 Sept 14, In: EMBO Molecular Medicine. 12, 10, e12118.Research output: Contribution to journal › Article › peer-review
Open Access -
Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer
Larsson, C., Ehinger, A., Winslow, S., Leandersson, K., Klintman, M., Dahl, L., Vallon-christersson, J., Häkkinen, J., Hegardt, C., Manjer, J., Saal, L., Rydén, L., Malmberg, M., Borg, Å. & Loman, N., 2020 Jul 6, In: npj Breast Cancer. 6, 1, 28.Research output: Contribution to journal › Article › peer-review
Open Access -
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Glodzik, D., Bosch, A., Hartman, J., Aine, M., Vallon-Christersson, J., Reuterswärd, C., Karlsson, A., Mitra, S., Niméus, E., Holm, K., Häkkinen, J., Hegardt, C., Saal, L. H., Larsson, C., Malmberg, M., Rydén, L., Ehinger, A., Loman, N., Kvist, A. & Ehrencrona, H. & 3 others, , 2020, In: Nature Communications. 11, 1, 3747.Research output: Contribution to journal › Article › peer-review
Open Access -
Psychological resilience and health-related quality of life in Swedish women with newly diagnosed breast cancer
Mohlin, Å., Axelsson, U., Bendahl, P. O., Borrebaeck, C., Hegardt, C., Johnsson, P., Hallberg, I. R. & Rydén, L., 2020, In: Cancer Management and Research. 12, p. 12041-12051 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series
Vallon-Christersson, J., Häkkinen, J., Hegardt, C., Saal, L., Larsson, C., Ehinger, A., Lindman, H., Olofsson, H., Sjoblom, T., Wärnberg, F., Rydén, L., Loman, N., Malmberg, M., Borg, Å. & Staaf, J., 2019 Aug 21, In: Scientific Reports. 9, 12184.Research output: Contribution to journal › Article › peer-review
Open Access -
Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer
Lundgren, C., Bendahl, P.-O., Ehinger, A., Hegardt, C., Larsson, C., Loman, N., Malmberg, M., Olofsson, H., Saal, L., Sjoblom, T., Lindman, H., Klintman, M., Häkkinen, J., Vallon-Christersson, J., Fernö, M., Rydén, L. & Ekholm, M., 2019 Aug 20, In: Breast Cancer Research and Treatment. p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Prediction of lymph node metastasis in breast cancer by gene expression and clinicopathological models: Development and validation within a population based cohort.
Dihge, L., Vallon-Christersson, J., Hegardt, C., Saal, L., Häkkinen, J., Larsson, C., Ehinger, A., Loman, N., Malmberg, M., Bendahl, P.-O., Borg, Å., Staaf, J. & Rydén, L., 2019 Jul 24, In: Clinical Cancer Research. 25, 21, p. 6368-6381Research output: Contribution to journal › Article › peer-review
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Refinement of breast cancer molecular classification by miRNA expression profiles
Søkilde, R., Persson, H., Ehinger, A., Pirona, A. C., Fernö, M., Hegardt, C., Larsson, C., Loman, N., Malmberg, M., Rydén, L., Saal, L., Borg, Å., Vallon-Christerson, J. & Rovira, C., 2019 Jun 17, In: BMC Genomics. 20, 1, 12 p., 503.Research output: Contribution to journal › Article › peer-review
Open Access -
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study
Staaf, J., Glodzik, D., Bosch, A., Vallon-Christersson, J., Reuterswärd, C., Häkkinen, J., Degasperi, A., Amarante, T. D., Saal, L. H., Hegardt, C., Stobart, H., Ehinger, A., Larsson, C., Rydén, L., Loman, N., Malmberg, M., Kvist, A., Ehrencrona, H., Davies, H. R. & Borg, Å. & 1 others, , 2019, In: Nature Medicine. 25, p. 1526–1533Research output: Contribution to journal › Article › peer-review
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2018
The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
Huang, X., Borgström, B., Stegmayr, J., Abassi, Y., Kruszyk, M., Leffler, H., Persson, L., Albinsson, S., Massoumi, R., Scheblykin, I. G., Hegardt, C., Oredsson, S. & Strand, D., 2018 Jun 27, In: ACS Central Science. 4, 6, p. 760-767 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative
Brueffer, C., Vallon-Christersson, J., Grabau, D., Ehinger, A., Häkkinen, J., Hegardt, C., Malina, J., Chen, Y., Bendahl, P.-O., Manjer, J., Malmberg, M., Larsson, C., Loman, N., Rydén, L., Borg, Å. & Saal, L. H., 2018 Mar 9, In: JCO Precision Oncology. 2, p. 1-18Research output: Contribution to journal › Article › peer-review
Open Access -
Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative
Rydén, L., Loman, N., Larsson, C., Hegardt, C., Vallon-Christersson, J., Malmberg, M., Lindman, H., Ehinger, A., Saal, L. H. & Borg, Å., 2018 Jan 17, In: British Journal of Surgery. 105, 2, p. e158–e168Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Structure–Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Selectivity of Semi-synthetic Derivatives
Borgström, B., Huang, X., Hegardt, C., Oredsson, S. & Strand, D., 2017 Feb 10, In: Chemistry - A European Journal. 23, 9, p. 2077-2083 7 p.Research output: Contribution to journal › Article › peer-review
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2016
Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic
Winter, C., Nilsson, M. P., Olsson, E., George, A. M., Chen, Y., Kvist, A., Törngren, T., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Jönsson, G., Grabau, D., Malmberg, M., Kristoffersson, U., Rehn, M., Gruvberger-Saal, S. K., Larsson, C., Borg, Å., Loman, N. & Saal, L. H., 2016 Aug, In: Annals of Oncology. 27, 8, p. 1532-8 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs.
Huang, X., Borgström, B., Kempengren, S., Persson, L., Hegardt, C., Strand, D. & Oredsson, S., 2016, In: BMC Cancer. 16, 1, 145.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.
Sjöström, M., Werner Hartman, L., Honeth, G., Grabau, D., Malmström, P., Hegardt, C., Fernö, M. & Niméus, E., 2015, In: Journal of Clinical Pathology. 68, 12, p. 1012-1019Research output: Contribution to journal › Article › peer-review
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The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine.
Saal, L., Vallon-Christersson, J., Häkkinen, J., Hegardt, C., Grabau, D., Winter, C., Brueffer, C., Tang, M.-H. E., Reuterswärd, C., Schulz, R., Karlsson, A. K., Ehinger, A., Malina, J., Manjer, J., Malmberg, M., Larsson, C., Rydén, L., Loman, N. & Borg, Å., 2015, In: Genome Medicine. 7, 1, 20.Research output: Contribution to journal › Article › peer-review
Open AccessFile345 Downloads (Pure) -
2014
Semisynthesis of SY-1 for Investigation of Breast Cancer Stem Cell Selectivity of C-Ring-Modified Salinomycin Analogues.
Huang, X., Borgström, B., Månsson, L., Persson, L., Oredsson, S., Hegardt, C. & Strand, D., 2014, In: ACS Chemical Biology. 9, 7, p. 1587-1594Research output: Contribution to journal › Article › peer-review
Open Access -
2013
Synthetic modification of salinomycin: selective O-acylation and biological evaluation
Borgström, B., Huang, X., Posta, M., Hegardt, C., Oredsson, S. & Strand, D., 2013, In: Chemical Communications. 49, 85, p. 9944-9946 3 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2012
Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours.
Holm, K., Staaf, J., Jönsson, G. B., Vallon-Christersson, J., Gunnarsson, H., Arason, A., Magnusson, L., Barkardottir, R. B., Hegardt, C., Ringnér, M. & Borg, Å., 2012, In: Breast Cancer Research and Treatment. 133, 2, p. 583-594Research output: Contribution to journal › Article › peer-review
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Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes.
Holm, K., Grabau, D., Lövgren, K., Aradottir, S., Gruvberger, S., Howlin, J., Saal, L., Ethier, S. P., Bendahl, P.-O., Stål, O., Malmström, P., Fernö, M., Rydén, L., Hegardt, C., Borg, Å. & Ringnér, M., 2012, In: Molecular Oncology. 6, 5, p. 494-506Research output: Contribution to journal › Article › peer-review
Open Access -
The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer.
Jönsson, G. B., Staaf, J., Vallon-Christersson, J., Ringnér, M., Gruvberger, S., Saal, L., Holm, K., Hegardt, C., Arason, A., Fagerholm, R., Olsson, C., Grabau, D., Johnsson, E., Lövgren, K., Magnusson, L., Heikkilä, P., Agnarsson, B. A., Johannsson, O. T., Malmström, P. & Fernö, M. & 5 others, , 2012, In: Cancer Research. 72, 16, p. 4028-4036Research output: Contribution to journal › Article › peer-review
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2011
CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers.
Olsson, E., Honeth, G., Bendahl, P.-O., Saal, L., Gruvberger, S., Ringnér, M., Vallon-Christersson, J., Jönsson, G. B., Holm, K., Lövgren, K., Fernö, M., Grabau, D., Borg, Å. & Hegardt, C., 2011, In: BMC Cancer. 11, 418.Research output: Contribution to journal › Article › peer-review
Open AccessFile351 Downloads (Pure) -
The antiproliferative effect of dietary fibre phenolic compounds ferulic acid and p-coumaric acid on the cell cycle in Caco-2 cells
Janicke, B., Hegardt, C., Krogh, M., Önning, G., Åkesson, B., Cirenajwis, H. & Oredsson, S., 2011, In: Nutrition and Cancer. 63, p. 611-622 12 p.Research output: Contribution to journal › Article › peer-review
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2010
Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics
Jönsson, G. B., Staaf, J., Vallon-Christersson, J., Ringnér, M., Holm, K., Hegardt, C., Gunnarsson, H., Fagerholm, R., Forsare, C., Agnarsson, B. A., Kilpivaara, O., Luts, L., Heikkila, P., Aittomaki, K., Blomqvist, C., Loman, N., Malmström, P., Olsson, H., Johannsson, O. T. & Arason, A. & 3 others, , 2010, In: Breast Cancer Research. 12, 3, R42.Research output: Contribution to journal › Article › peer-review
Open AccessFile318 Downloads (Pure) -
Identification of Subtypes in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Reveals a Gene Signature Prognostic of Outcome.
Staaf, J., Ringnér, M., Vallon-Christersson, J., Jönsson, G. B., Bendahl, P.-O., Holm, K., Arason, A., Gunnarsson, H., Hegardt, C., Agnarsson, B. A., Luts, L., Grabau, D., Fernö, M., Malmström, P., Johannsson, O. T., Loman, N., Barkardottir, R. B. & Borg, Å., 2010, In: Journal of Clinical Oncology. 28, 11, p. 1813-1820Research output: Contribution to journal › Article › peer-review
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Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Holm, K., Hegardt, C., Staaf, J., Vallon-Christersson, J., Jönsson, G. B., Olsson, H., Borg, Å. & Ringnér, M., 2010, In: Breast Cancer Research. 12, 3, R36.Research output: Contribution to journal › Article › peer-review
Open AccessFile305 Downloads (Pure) -
Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.
Rennstam, K., McMichael, N., Berglund, P., Honeth, G., Hegardt, C., Rydén, L., Luts, L., Bendahl, P.-O. & Hedenfalk, I., 2010, In: Breast Cancer Research and Treatment. 122, p. 315-324Research output: Contribution to journal › Article › peer-review
File233 Downloads (Pure) -
Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
Cirenajwis, H., Smiljanic, S., Honeth, G., Hegardt, C., Marton, L. J. & Oredsson, S., 2010, In: Anti-Cancer Drugs. 21, 10, p. 897-906Research output: Contribution to journal › Article › peer-review
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2008
Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines.
Myhre, L., Alm, K., Hegardt, C., Staaf, J., Jönsson, G. B., Larsson, S. & Oredsson, S., 2008, In: Anti-Cancer Drugs. 19, 4, p. 359-368Research output: Contribution to journal › Article › peer-review
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Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.
Johansson, V., Falck Miniotis, M., Hegardt, C., Jönsson, G. B., Staaf, J., Berntsson, P., Oredsson, S. & Alm, K., 2008, In: Cell Biology International. 32, p. 1467-1477Research output: Contribution to journal › Article › peer-review
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Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line.
Holst, M., Staaf, J., Jönsson, G. B., Hegardt, C. & Oredsson, S., 2008, In: Anti-Cancer Drugs. 19, 9, p. 871-883Research output: Contribution to journal › Article › peer-review
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The CD44(+)/CD24(-) phenotype is enriched in basal-like breast tumors
Honeth, G., Bendahl, P.-O., Ringnér, M., Saal, L., Gruvberger, S., Lövgren, K., Grabau, D., Fernö, M., Borg, Å. & Hegardt, C., 2008, In: Breast Cancer Research. 10, 3, R53.Research output: Contribution to journal › Article › peer-review
Open Access -
2007
Estrogen receptor beta expression is associated with tamoxifen response in ER alpha-negative breast carcinoma
Gruvberger, S., Bendahl, P.-O., Saal, L. H., Laakso, M., Hegardt, C., Edén, P., Peterson, C., Malmström, P., Isola, J., Borg, Å. & Fernö, M., 2007, In: Clinical Cancer Research. 13, 7, p. 1987-1994 8 p.Research output: Contribution to journal › Article › peer-review
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2006
Induction of apoptotic cell death by putrescine.
Takao, K., Rickhag, M., Hegardt, C., Oredsson, S. & Persson, L., 2006, In: International Journal of Biochemistry & Cell Biology. 38, 4, p. 621-628Research output: Contribution to journal › Article › peer-review
File232 Downloads (Pure) -
2005
Intratumor versus intertumor heterogeneity in gene expression profiles of soft-tissue sarcomas.
Francis, P., Fernebro, J., Edén, P., Laurell, A., Rydholm, A., Domanski, H., Breslin, T., Hegardt, C., Borg, Å. & Nilbert, M., 2005, In: Genes, Chromosomes and Cancer. 43, 3, p. 302-308Research output: Contribution to journal › Article › peer-review
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2003
Spermine prevents cytochrome c release in glucocorticoid-induced apoptosis in mouse thymocytes.
Hegardt, C., Andersson, G. & Oredsson, S., 2003, In: Cell Biology International. 27, 2, p. 115-121Research output: Contribution to journal › Article › peer-review
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2002
Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N-1,N-11-diethylnorspermine
Hegardt, C., Johannsson, O. & Oredsson, S., 2002, In: European Journal of Biochemistry. 269, 3, p. 1033-1039Research output: Contribution to journal › Article › peer-review
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2001
Different roles of spermine in glucocorticoid- and Fas-induced apoptosis
Hegardt, C., Andersson, G. & Oredsson, S., 2001, In: Experimental Cell Research. 266, 2, p. 333-341Research output: Contribution to journal › Article › peer-review
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2000
Changes in polyamine metabolism during glucocorticoid-induced programmed cell death in mouse thymus
Hegardt, C., Andersson, G. & Oredsson, S., 2000, In: Cell Biology International. 24, 12, p. 871-880Research output: Contribution to journal › Article › peer-review