Charlotte Rolny

Our research primarily focuses on tumor immunology, with a particular emphasis on understanding the behavior of Tumor-Associated Macrophages (TAMs) and is dedicated to finding novel targets that reprogram immunosuppressive and pro-metastatic Tumor-Associated Macrophages into an anti-tumor phenotype. Our lab employs state-of-the-art molecular biology techniques, mouse models, and patient samples to uncover mechanisms that regulate TAM phenotypes. By targeting these mechanisms, the overarching aim is to reprogram pro-tumoral TAMs into an anti-tumoral state, affecting various components of the non-cancer cells residing in the tumor microenvironment, ultimately inhibiting tumor growth and metastasis.

Current projects

• Studying the crosstalk between TAMs phenotypes and the Tumor Microenvironment
• Metabolic pathways that regulate TAM phenotypes.
• Exploiting TAM subtypes for chemotherapy efficacy.
• TAMs as predictive and prognostic tools in breast cancer, adult and pediatric sarcoma and other solid tumors