Research output per year
Research output per year
Personal profile
Research
Our research primarily focuses on tumor immunology, with a particular emphasis on understanding the behavior of Tumor-Associated Macrophages (TAMs) and is dedicated to finding novel targets that reprogram immunosuppressive and pro-metastatic Tumor-Associated Macrophages into an anti-tumor phenotype. Our lab employs state-of-the-art molecular biology techniques, mouse models, and patient samples to uncover mechanisms that regulate TAM phenotypes. By targeting these mechanisms, the overarching aim is to reprogram pro-tumoral TAMs into an anti-tumoral state, affecting various components of the non-cancer cells residing in the tumor microenvironment, ultimately inhibiting tumor growth and metastasis.
Professional work
Current projects
- Studying the crosstalk between TAMs phenotypes and the Tumor Microenvironment
- Metabolic pathways that regulate TAM phenotypes.
- Exploiting TAM subtypes for chemotherapy efficacy.
- TAMs as predictive and prognostic tools in breast cancer, adult and pediatric sarcoma and other solid tumors
Free keywords
- immuno-oncology
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
- 1 Article
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An Activin Receptor-Like Kinase 1-governed monocytic lineage shapes an immunosuppressive landscape in breast cancer metastases
Safaee Talkhoncheh, M., Sjölund, J., Bolivar, P., Kurzejamska, E., Cordero, E., Vallès Pagès, T., Larsson, S., Lehn, S., Frimannsson, G., Ingesson, V., Braun, S., Pantaleo, J., Oudenaarden, C., Lauss, M., Pearsall, R. S., Jönsson, G. B., Rolny, C., Bocci, M. & Pietras, K., 2025, In: The Journal of clinical investigation. 135, 5Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 2 Active
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Understanding the underlying mechanisms that regulate immune cells to become tumourigenic
Rolny, C. (PI)
2024/08/15 → 2026/12/15
Project: Research
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Unlocking the Prognostic and Mechanistic Potential of Tumor-Associated Macrophages
Rolny, C. (PI)
Mrs. Berta Kamprad's Cancer Foundation
2024/04/02 → 2029/02/28
Project: Research
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LUCC - Breast and Imaging & nuclear/radiology: Retreat
Saal, L. (Organiser), Skarping, I. (Organiser), Massoumi, R. (Organiser), Skarping, I. (Session chair), Zackrisson, S. (Speaker), Ryden, L. (Speaker), van Brakel, J. (Speaker), Alkner, S. (Speaker), Saal, L. (Session chair), Rantalainen, M. (Keynote/plenary speaker), Lehn, S. (Session chair), Jessica, P. (Speaker), Olsson, L. E. (Speaker), Massoumi, R. (Session chair), Sydoff, M. (Speaker), Barrientos Baeza, S. (Speaker), Rolny, C. (Speaker), Ahlin Gullers, A. (Speaker), Olsson, J. (Speaker), Wiklund, H. (Speaker), Loman, N. (Speaker), Kimbung, S. (Session chair), Heiberg, E. (Speaker), Swaminathan, V. (Speaker), Bourgine, P. (Speaker), Saal, L. (Speaker), Vallon-Christersson, J. (Speaker) & Staaf, J. (Speaker)
2025 Mar 20 → 2025 Mar 21Activity: Participating in or organising an event › Organisation of conference
File -
LUCC - Immunology, tumour microenvironment & metastasis Minisymposium
Leandersson, K. (Organiser), Sandström Gerdtsson, A. (Organiser), Rolny, C. (Presenter) & Briem, O. (Presenter)
2024 Sept 27Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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LUCC - Breast: Meeting
Saal, L. (Organiser), Alkner, S. (Organiser), Stridh, M. (Presenter), Rolny, C. (Presenter) & Kimbung, S. (Presenter)
2024 Apr 23Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course