Research output per year
Research output per year
Personal profile
Research
My research focuses on the development of diagnostics based on tumor DNA/RNA deep sequencing (also known as next generation sequencing) to improve treatment and survival of cancer patients. Most of my projects are embedded in the Sweden Cancerome Analysis Network Breast (SCAN-B) breast cancer study. Additionally I work on improving open source bioinformatics and reproducible research infrastructure by contributing to projects such as conda-forge, Bioconda, and Biopython.
UKÄ subject classification
- Bioinformatics (Computational Biology)
- Bioinformatics and Systems Biology
- Cancer and Oncology
Keywords
- Cancer Genomics
- Genomics
- Biomarkers
- Next-Generation Sequencing
- RNA-seq
- Liquid Biopsy
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Research output
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The mutational landscape of the SCAN‐B real‐world primary breast cancer transcriptome
Brueffer, C., Gladchuk, S., Winter, C., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., George, A., Chen, Y., Ehinger, A., Larsson, C., Loman, N., Malmberg, M., Ryden, L., Borg, Å. & Saal, L., 2020 Sep 14, In: EMBO Molecular Medicine. 12, 10, e12118.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (SciVal) -
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer
Dahlgren, M., George, A., Brueffer, C., Gladchuk, S., Chen, Y., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Ryden, L., Malmberg, M., Larsson, C., Gruvberger, S., Ehinger, A., Loman, N., Borg, Å. & Saal, L., 2021 Apr 22, In: JNCI Cancer Spectrum. 5, 2, pkab028.Research output: Contribution to journal › Article › peer-review
Open Access -
Bioconda: sustainable and comprehensive software distribution for the life sciences
Grüning, B., Dale, R., Sjödin, A., Chapman, B. A., Rowe, J., Tomkins-Tinch, C. H., Valieris, R., Köster, J., Bioconda Team & Brueffer, C., 2018 Jul 2, In: Nature Methods. 15, 7, p. 475-476 2 p.Research output: Contribution to journal › Letter › peer-review
228 Citations (SciVal) -
Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative
Brueffer, C., Vallon-Christersson, J., Grabau, D., Ehinger, A., Häkkinen, J., Hegardt, C., Malina, J., Chen, Y., Bendahl, P-O., Manjer, J., Malmberg, M., Larsson, C., Loman, N., Rydén, L., Borg, Å. & Saal, L. H., 2018 Mar 9, In: JCO Precision Oncology. 2, p. 1-18Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (SciVal) -
RNA Sequencing for Molecular Diagnostics in Breast Cancer
Brueffer, C., 2021, Lund: Lund University, Faculty of Medicine. 110 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile772 Downloads (Pure)
Projects
- 1 Finished
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RNA sequencing for molecular diagnostics in breast cancer
Brueffer, C., Saal, L., Höglund, M. & Axelson, H.
2014/06/01 → 2021/01/13
Project: Dissertation
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Program Committee at BOSC 2021
Christian Brueffer (Reviewer)
2021 May 6 → 2021 Jul 30Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)
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Program Committee at BOSC/BCC 2020
Christian Brueffer (Reviewer)
2020 May 3 → 2020 Jul 21Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)
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Program Committee at BOSC 2019
Christian Brueffer (Reviewer)
2019 Apr 11 → 2019 Jul 25Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)
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Defining the Mutational Landscape of the Primary Breast Cancer Transcriptome through large-scale RNA-seq in the Sweden Cancerome Analysis Network–Breast (SCAN-B) Project
Christian Brueffer (Speaker)
2019 Oct 4Activity: Talk or presentation › Presentation
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Towards Better Breast Cancer Diagnostics: Large-scale Profiling of Tumor Transcriptomes
Christian Brueffer (Speaker)
2019 May 23Activity: Talk or presentation › Presentation