Research output per year
Research output per year
Personal profile
Research
I am a bioinformatician and biomedical data scientist. My main interest is in using computational methods and biological/medical data to improve our understanding and treatment of diseases. Many of my projects, including my doctoral thesis, have been focused on cancer in humans, particularly using data from the Sweden Cancerome Analysis Network Breast (SCAN-B) breast cancer study. Additionally I work on improving open source bioinformatics and reproducible research infrastructure by contributing to projects such as conda-forge, Bioconda, and Biopython.
For consulting inquiries, please visit https://insilico.consulting.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Bioinformatics (Computational Biology)
- Bioinformatics and Systems Biology
- Cancer and Oncology
Free keywords
- Bioinformatics
- Cancer Genomics
- Cancer
- Genomics
- Biomarkers
- Next Generation Sequencing
- RNA-seq
- Transcriptomics
- Liquid Biopsy
- Precision Medicine
- Data Science
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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The mutational landscape of the SCAN‐B real‐world primary breast cancer transcriptome
Brueffer, C., Gladchuk, S., Winter, C., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., George, A., Chen, Y., Ehinger, A., Larsson, C., Loman, N., Malmberg, M., Ryden, L., Borg, Å. & Saal, L., 2020 Sept 14, In: EMBO Molecular Medicine. 12, 10, e12118.Research output: Contribution to journal › Article › peer-review
Open Access -
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer
Dahlgren, M., George, A., Brueffer, C., Gladchuk, S., Chen, Y., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Ryden, L., Malmberg, M., Larsson, C., Gruvberger, S., Ehinger, A., Loman, N., Borg, Å. & Saal, L., 2021 Apr 22, In: JNCI Cancer Spectrum. 5, 2, pkab028.Research output: Contribution to journal › Article › peer-review
Open Access -
Bioconda: sustainable and comprehensive software distribution for the life sciences
Grüning, B., Dale, R., Sjödin, A., Chapman, B. A., Rowe, J., Tomkins-Tinch, C. H., Valieris, R., Köster, J., Bioconda Team & Brueffer, C. (Contributor), 2018 Jul 2, In: Nature Methods. 15, 7, p. 475-476 2 p.Research output: Contribution to journal › Letter › peer-review
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Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative
Brueffer, C., Vallon-Christersson, J., Grabau, D., Ehinger, A., Häkkinen, J., Hegardt, C., Malina, J., Chen, Y., Bendahl, P.-O., Manjer, J., Malmberg, M., Larsson, C., Loman, N., Rydén, L., Borg, Å. & Saal, L. H., 2018 Mar 9, In: JCO Precision Oncology. 2, p. 1-18Research output: Contribution to journal › Article › peer-review
Open Access -
RNA Sequencing for Molecular Diagnostics in Breast Cancer
Brueffer, C., 2021, Lund: Lund University, Faculty of Medicine. 110 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile1611 Downloads (Pure)
Projects
- 1 Finished
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RNA sequencing for molecular diagnostics in breast cancer
Brueffer, C. (PI), Saal, L. (Supervisor), Höglund, M. (Assistant supervisor) & Axelson, H. (Assistant supervisor)
2014/06/01 → 2021/01/13
Project: Dissertation
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Program Committee at BOSC 2021
Brueffer, C. (Reviewer)
2021 May 6 → 2021 Jul 30Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)
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Program Committee at BOSC/BCC 2020
Brueffer, C. (Reviewer)
2020 May 3 → 2020 Jul 21Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)
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Defining the Mutational Landscape of the Primary Breast Cancer Transcriptome through large-scale RNA-seq in the Sweden Cancerome Analysis Network–Breast (SCAN-B) Project
Brueffer, C. (Speaker)
2019 Oct 4Activity: Talk or presentation › Presentation
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Towards Better Breast Cancer Diagnostics: Large-scale Profiling of Tumor Transcriptomes
Brueffer, C. (Speaker)
2019 May 23Activity: Talk or presentation › Presentation
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Program Committee at BOSC 2019
Brueffer, C. (Reviewer)
2019 Apr 11 → 2019 Jul 25Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)