Research output per year
Research output per year
Personal profile
Research
I am a bioinformatician and biomedical data scientist. My main interest is in using computational methods and biological/medical data to improve our understanding and treatment of diseases. Many of my projects, including my doctoral thesis, have been focused on cancer in humans, particularly using data from the Sweden Cancerome Analysis Network Breast (SCAN-B) breast cancer study. Additionally I work on improving open source bioinformatics and reproducible research infrastructure by contributing to projects such as conda-forge, Bioconda, and Biopython.
For consulting inquiries, please visit https://insilico.consulting.
Subject classification (UKÄ)
- Bioinformatics (Computational Biology)
- Bioinformatics and Computational Biology
- Cancer and Oncology
- Basic Cancer Research
Free keywords
- Bioinformatics
- Cancer Genomics
- Cancer
- Genomics
- Oncology
- Next Generation Sequencing
- RNA-seq
- Transcriptomics
- Liquid Biopsy
- Precision Medicine
- Data Science
- ctDNA
- Biomarkers
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 9 Industry, Innovation, and Infrastructure
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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NeoCircle: pre- and post-operative circulating tumor DNA dynamics predicts survival in neoadjuvant-treated early breast cancer
George, A. M., Chen, Y., Gladchuk, S., Alcaide, M., Dalal, H., Meng, P., Brueffer, C., Saghir, H., Kimbung, S., Aaltonen, K., Oton, L., Rushton, C., Birkeälv, S., Jönsson, M., Zackrisson, S., Skarping, I., Förnvik, D., Zander, L., Honeth, G. & Woodhouse, S. & 7 others, , 2026 May 26, (E-pub ahead of print) In: EMBO Molecular Medicine. p. 1-18Research output: Contribution to journal › Article › peer-review
Open Access -
ctDNA as an Objective Marker for Postoperative Residual Disease in Primary Advanced High-Grade Serous Ovarian Cancer
Glueck, V., Grimm, C., Postl, M., Brueffer, C., Segui Gracia, N., Alcaide, M., Oton, L., Chen, Y., Saal, L., Hofstetter, G., Polterauer, S. & Muellauer, L., 2025 Feb 25, In: Cancers. 17, 5, 786.Research output: Contribution to journal › Article › peer-review
Open Access -
Genomic Characteristics Related to Histology-based Immune Features in Breast Cancer
Cha, Y. J., O'Connell, C. E., Calhoun, B. C., Felsheim, B. M., Fernandez-Martinez, A., Fan, C., Brueffer, C., Larsson, C., Borg, Å., Saal, L. H. & Perou, C. M., 2025, In: Modern Pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 38, 5, 100736.Research output: Contribution to journal › Article › peer-review
Open Access -
The fifth international hackathon for developing computational cloud-based tools and resources for pan-structural variation and genomics
Deb, S. K., Kalra, D., Kubica, J., Stricker, E., Truong, V. Q., Zeng, Q., Fiscus, C. J., Agustinho, D. P., Alexander, A., Arciniega-Sanchez, M., Bosseau, L., Brueffer, C., Canal, A., Daw, J., Enoma, D., Diaz-Cuevas, A., Diesh, C., Doolittle-Hall, J. M., Fernandez-Luna, L. & Han, T. & 29 others, , 2024 Jun 27, In: F1000Research. 13, p. 1-33 708.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
De Marchi, T., Lai, C.-F., Simmons, G. M., Goldsbrough, I., Harrod, A., Lam, T., Buluwela, L., Kjellström, S., Brueffer, C., Saal, L. H., Malmström, J., Ali, S. & Niméus, E., 2024 Mar 22, In: Scientific Reports. 14, p. 1-16 6873.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Finished
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RNA sequencing for molecular diagnostics in breast cancer
Brueffer, C. (PI), Saal, L. (Supervisor), Höglund, M. (Assistant supervisor) & Axelson, H. (Assistant supervisor)
2014/06/01 → 2021/01/13
Project: Dissertation
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Program Committee at BOSC 2021
Brueffer, C. (Reviewer)
2021 May 6 → 2021 Jul 30Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)
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Program Committee at BOSC/BCC 2020
Brueffer, C. (Reviewer)
2020 May 3 → 2020 Jul 21Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)
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Defining the Mutational Landscape of the Primary Breast Cancer Transcriptome through large-scale RNA-seq in the Sweden Cancerome Analysis Network–Breast (SCAN-B) Project
Brueffer, C. (Speaker)
2019 Oct 4Activity: Talk or presentation › Presentation
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Towards Better Breast Cancer Diagnostics: Large-scale Profiling of Tumor Transcriptomes
Brueffer, C. (Speaker)
2019 May 23Activity: Talk or presentation › Presentation
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Program Committee at BOSC 2019
Brueffer, C. (Reviewer)
2019 Apr 11 → 2019 Jul 25Activity: Consultancy, expert advice and memberships › Member of peer review panel or committee (not publications)