Research output per year
Research output per year
Personal profile
Research
I apply biochemical, structural and functional genomic methods to explore molecular mechanisms of chromatin regulation in human cells. I am particularly interested in: (i) relating macromolecular structure, interactions and dynamics to function, (ii) designing innovative assays to perturb processes of medical interest, and (iii) building collaborations to tackle important questions in molecular medicine.
My current research seeks to understand transcriptional regulation by a poorly-characterized family of nuclear ATPases, the human microchordia CW-type zinc finger proteins (MORCs). MORCs repress genes and mobile genetic elements to maintain genome stability but we do not understand how silencing is imposed and why particular genetic elements are specifically targeted. A clear picture of the relationship between MORCs and epigenetic pathways is lacking. Patient mutations in MORC genes cause a range of neurodevelopmental disorders, demonstrating that accurate MORC functions are vital to human health.
For more information on publications and funding sources, see here and here.
UKÄ subject classification
- Medical Genetics
Keywords
- Chromatin
- Epigenetics
- Transposons
- Transcription
- Protein Structure
- Functional Genomics
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Research output
- 6 Article
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A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
Johansson, P. A., Brattås, P. L., Douse, C. H., Hsieh, P., Adami, A., Pontis, J., Grassi, D., Garza, R., Sozzi, E., Cataldo, R., Jönsson, M. E., Atacho, D. A. M., Pircs, K., Eren, F., Sharma, Y., Johansson, J., Fiorenzano, A., Parmar, M., Fex, M., Trono, D., & 2 others, 2022, In: Cell Stem Cell. 29, 1, p. 52-69.e8Research output: Contribution to journal › Article › peer-review
Open Access -
Structure and functional mapping of the KRAB-KAP1 repressor complex
Stoll, G. A., Pandiloski, N., Douse, C. H. & Modis, Y., 2022 Dec 15, In: EMBO Journal. 41, 24, 16 p., e111179.Research output: Contribution to journal › Article › peer-review
Open Access -
Periphilin self-association underpins epigenetic silencing by the HUSH complex
Prigozhin, D. M., Douse, C. H., Albecka, A., Tchasovnikarova, I. A., Timms, R. T., Oda, S-I., Adolf, F., Freund, S. M. V., Maslen, S., Lehner, P. J. & Modis, Y., 2020 Oct 9, In: Nucleic Acids Research. 48, 18, p. 10313-10328Research output: Contribution to journal › Article › peer-review
Open Access -
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Douse, C. H., Tchasovnikarova, I. A., Timms, R. T., Protasio, A. V., Seczynska, M., Prigozhin, D. M., Albecka, A., Wagstaff, J., Williamson, J. C., Freund, S. M. V., Lehner, P. J. & Modis, Y., 2020, In: Nature Communications. 11, 1, 4940.Research output: Contribution to journal › Article › peer-review
Open Access -
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
Douse, C. H., Bloor, S., Liu, Y., Shamin, M., Tchasovnikarova, I. A., Timms, R. T., Lehner, P. J. & Modis, Y., 2018 Feb 13, In: Nature Communications. 9, 651.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active
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Epigenetic regulation of Transposable Elements in human health, development and disease
Pandiloski, N., Jakobsson, J. & Douse, C.
2020/09/15 → …
Project: Dissertation