Personal profile
Research
Over three million people die each year and over 60 million people suffer worldwide from chronic lung diseases (CLDs). At present, there is no cure for CLDs, including chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and pulmonary fibrosis. Lung transplantation is the only option at end-stage disease and is further complicated by shortage in organs available for transplantation and low efficacy. Five-year survival rate has remained at 50% for the last decade. New options are desperately needed for these patients.
My lab focuses on understanding the role of the extracellular environment for endogenous and exogenous lung tissue regeneration in healthy and diseased lung. In particular, our work focuses on the design and use of biologic and synthetic scaffolds to bioengineer new lung tissue for transplantation. We further aim to build new models of human lung tissue to reduce animal usage, better understand how regeneration processes are deranged in CLDs, and for use as drug discovery and therapeutic screening platforms.
Subject classification (UKÄ)
- Cell and Molecular Biology
- Biomaterials Science
- Manufacturing, Surface and Joining Technology
Free keywords
- Lung Regeneration
- Tissue Engineering
- Stem Cells
- Biomaterials
- Mechanotransduction
- Hippo
- Bioengineering
- Ex vivo
- Bioreactor
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 5 Gender Equality -
SDG 12 Responsible Consumption and Production -
SDG 16 Peace, Justice and Strong Institutions
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Collaborations the last five years
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Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue
De Santis, M. M., Alsafadi, H. N., Tas, S., Bölükbas, D. A., Prithiviraj, S., Da Silva, I. A., Mittendorfer, M., Ota, C., Stegmayr, J., Daoud, F., Königshoff, M., Swärd, K., Wood, J. A., Tassieri, M., Bourgine, P. E., Lindstedt, S., Mohlin, S. & Wagner, D. E., 2021, In: Advanced Materials. 33, 3, 2005476.Research output: Contribution to journal › Article › peer-review
Open Access -
Isolation of high yield and quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts
Stegmayr, J., Alsafadi, H. N., Langwinski, W., Niroomand, A., Lindstedt, S., Leigh, N. D. & Wagner, D. E., 2021, In: American Journal of Physiology: Lung Cellular and Molecular Physiology. 320, 2, p. L232-L240Research output: Contribution to journal › Article › peer-review
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Simultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations
Alsafadi, H. N., Stegmayr, J., Ptasinski, V., Silva, I., Mittendorfer, M., Murray, L. A. & Wagner, D. E., 2022, In: Stem Cell Reports. 17, 12, p. 2718-2731Research output: Contribution to journal › Article › peer-review
Open Access -
Organ-Restricted Vascular Delivery of Nanoparticles for Lung Cancer Therapy
Bölükbas, D., Datz, S., Meyer-Schwickerath, C., Morrone, C., Doryab, A., Gössl, D., Vreka, M., Yang, L., Argyo, C., van Rijt, S., Lindner, M., Eickelberg, O., Stoeger, T., Schmid, O., Lindstedt, S., Stathopoulos, G. T., Bein, T., Wagner, D. E. & Meiners, S., 2020 Jul 1, In: Advanced Therapeutics. 3, 7, 2000017.Research output: Contribution to journal › Article › peer-review
Open Access -
Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro
Petrou, C. L., D'Ovidio, T. J., Bölükbas, D., Tas, S., Brown, R. D., Allawzi, A., Lindstedt Ingemansson, S., Nozik-Grayck, E., Stenmark, K. R., Wagner, D. & Magin, C. M., 2020 Aug 21, In: Journal of Materials Chemistry B. 8, 31, p. 6814-6826Research output: Contribution to journal › Article › peer-review
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Apical-out human airway organoids-on-a-chip derived from iPSCs for studying bacterial infections
Wagner, D. (PI) & Påhlman, L. (CoPI)
Wallenberg Centre for Molecular Medicine (WCMM)
2025/11/01 → 2027/12/31
Project: Research
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Biomaterials@LU
Hajizadeh, S. (PI), Larsson, M. (PI), Orlov, D. (PI), Dicko, C. (PI), Aits, S. (PI), Bourgine, P. (PI), Käll, J. (PI), Svensson Bonde, J. (PI), Raina, D. (PI), Nordin, M. (PI), Elowsson, L. (PI), Ibáñez-Fonseca, A. (PI), Wagner, D. (PI), Parvaneh, S. (Researcher), Wendi, I. P. (Researcher), Alsafadi, H. (Researcher) & Gvazava, N. (Researcher)
2023/09/01 → …
Project: Network
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Fabrication of hybrid decellularized extracellular matrix polycaprolactone nanofiber scaffolds for use in next generation lung-on-a-chip
Wagner, D. (PI)
2023/01/01 → 2027/12/31
Project: Research
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Deep Learning for Lung Image Analysis
Kazemi Rashed, S. (Researcher), Augusto Silva, I. (Researcher), Wagner, D. (Researcher) & Aits, S. (Researcher)
2021/03/01 → …
Project: Research
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Activities
- 2 Organisation of conference
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Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases
Wagner, D. (Chair)
2019 Jul 15 → 2019 Jul 18Activity: Participating in or organising an event › Organisation of conference
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Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases
Wagner, D. (Chair)
2017 Jul 24 → 2017 Jul 27Activity: Participating in or organising an event › Organisation of conference
Prizes and Distinction
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American Thoracic Society Science and Innovation Center Rising Star of Research
Wagner, D. (Recipient), 2017 May 21
Prize: National/international honour