Research output per year
Research output per year
Research output
- 1 - 50 out of 178 results
Search results
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2025
Zero-length crosslinking: A breakthrough approach for evaluating target engagement in a-synuclein immunotherapy
Rochet, J. C., Qi, W. & Kirik, D., 2025 Jan, In: Journal of Pharmacology and Experimental Therapeutics. 392, 1, 100036.Research output: Contribution to journal › Debate/Note/Editorial
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2024
Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain
Trist, B. G., Wright, C. J., Rangel, A., Cottle, L., Prasad, A., Jensen, N. M., Gram, H., Dzamko, N., Jensen, P. H. & Kirik, D., 2024 Dec, In: npj Parkinson's Disease. 10, 1, 217.Research output: Contribution to journal › Article › peer-review
Open Access -
State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons
Basso, V., Döbrössy, M. D., Thompson, L. H., Kirik, D., Fuller, H. R. & Gates, M. A., 2024 Sept, In: Biology. 13, 9, 690.Research output: Contribution to journal › Review article › peer-review
Open Access -
Image post-processing for SILMAS: structured illumination light sheet microscopy with axial sweeping
Frantz, D., Wright, C. J., Schaser, A. J., Kirik, D., Kristensson, E. & Berrocal, E., 2024 Aug, In: Biomedical Optics Express. 15, 8, p. 4943-4962 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Basal activity of PINK1 and PRKN in cell models and rodent brain
Watzlawik, J. O., Fiesel, F. C., Fiorino, G., Bustillos, B. A., Baninameh, Z., Markham, B. N., Hou, X., Hayes, C. S., Bredenberg, J. M., Kurchaba, N. W., Fričová, D., Siuda, J., Wszolek, Z. K., Noda, S., Sato, S., Hattori, N., Prasad, A. A., Kirik, D., Fox, H. S. & Stauch, K. L. & 2 others, , 2024, In: Autophagy. 20, 5, p. 1147-1158 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease
Sastre, D., Zafar, F., Torres, C. A. M., Piper, D., Kirik, D., Sanders, L. H., Qi, L. S. & Schüle, B., 2023 Dec, In: Scientific Reports. 13, 1, 17796.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease
Bergh, S., Gabery, S., Tonetto, S., Kirik, D., Petersén, Å. & Cheong, R. Y., 2023 Apr, In: Neuropathology and Applied Neurobiology. 49, 2, e12891.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of human-induced pluripotent-stem-cell-derived cortical neurons for high-throughput imaging of neurite morphology and neuron maturation
Wali, G., Li, Y., Abu-Bonsrah, D., Kirik, D., Parish, C. L. & Sue, C. M., 2023, In: STAR Protocols. 4, 2, 102325.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene
Pavan, C., Jin, J., Jong, S., Strbenac, D., Davis, R. L., Sue, C. M., Johnston, J., Lynch, T., Halliday, G., Kirik, D., Parish, C. L., Thompson, L. H. & Ovchinnikov, D. A., 2023, In: Stem Cell Research. 73, 103211.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks
Marciano, S., Ionescu, T. M., Saw, R. S., Cheong, R. Y., Kirik, D., Maurer, A., Pichler, B. J. & Herfert, K., 2022 Oct 4, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 40, e2122552119.Research output: Contribution to journal › Article › peer-review
Open Access -
High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping
Frantz, D., Karamahmutoglu, T., Schaser, A. J., Kirik, D. & Berrocal, E., 2022 Sept 1, In: Biomedical Optics Express. 13, 9, p. 4907-4925 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells
Moriarty, N., Gantner, C. W., Hunt, C. P. J., Ermine, C. M., Frausin, S., Viventi, S., Ovchinnikov, D. A., Kirik, D., Parish, C. L. & Thompson, L. H., 2022 Mar 3, In: Cell Stem Cell. 29, 3, p. 434-448.e5Research output: Contribution to journal › Article › peer-review
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Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats
Tugba, E. K., Medine, G. I. O., Ozlem, A., Deniz, K. & Filiz, O. Y., 2022, In: Pharmacology Biochemistry and Behavior. 213, 173317.Research output: Contribution to journal › Article › peer-review
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2021
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease
Arkan, S., Ljungberg, M., Kirik, D. & Hansen, C., 2021 Oct, In: Neurobiology of Disease. 158, 105477.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model
Cheong, R. Y., Baldo, B., Sajjad, M. U., Kirik, D. & Petersén, Å., 2021 Jun 1, In: Neuropathology and Applied Neurobiology. 47, 4, p. 564-578 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease
Huynh, B., Fu, Y., Kirik, D., Shine, J. M. & Halliday, G. M., 2021, In: Movement Disorders. 36, 9, p. 2085-2093Research output: Contribution to journal › Article › peer-review
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Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome
Petty, A., Cui, X., Ali, A., Du, Z., Srivastav, S., Kesby, J. P., Kirik, D., Howes, O. & Eyles, D., 2021, In: Scientific Reports. 11, 1, 4294.Research output: Contribution to journal › Article › peer-review
Open Access -
Structured light sheet microscopy for high contrast 3D imaging of whole mouse brain
Frantz, D., Karamahmutoglu, T., Kirik, D. & Berrocal, E., 2021, Novel Techniques in Microscopy, NTM 2021. Optical Society of America, NM2C.7. (Optics InfoBase Conference Papers).Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review
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Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease
Marmion, D. J., Rutkowski, A. A., Chatterjee, D., Hiller, B. M., Werner, M. H., Bezard, E., Kirik, D., McCown, T., Gray, S. J. & Kordower, J. H., 2021, In: Neurobiology of Disease. 148, 105184.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
Landeck, N., Strathearn, K. E., Ysselstein, D., Buck, K., Dutta, S., Banerjee, S., Lv, Z., Hulleman, J. D., Hindupur, J., Lin, L. K., Padalkar, S., Stanciu, L. A., Lyubchenko, Y. L., Kirik, D. & Rochet, J. C., 2020, In: Molecular Neurodegeneration. 15, 1, 49.Research output: Contribution to journal › Article › peer-review
Open Access -
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
Gantner, C. W., de Luzy, I. R., Kauhausen, J. A., Moriarty, N., Niclis, J. C., Bye, C. R., Penna, V., Hunt, C. P. J., Ermine, C. M., Pouton, C. W., Kirik, D., Thompson, L. H. & Parish, C. L., 2020, In: Cell Stem Cell. 26, 4, p. 511-526.e5Research output: Contribution to journal › Article › peer-review
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2019
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia
Petty, A., Cui, X., Tesiram, Y., Kirik, D., Howes, O. & Eyles, D., 2019, In: npj Schizophrenia. 5, 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access -
How is alpha-synuclein cleared from the cell?
Stefanis, L., Emmanouilidou, E., Pantazopoulou, M., Kirik, D., Vekrellis, K. & Tofaris, G. K., 2019, In: Journal of Neurochemistry. 150, 5, p. 577-590Research output: Contribution to journal › Review article › peer-review
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Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
Elfarrash, S., Jensen, N. M., Ferreira, N., Betzer, C., Thevathasan, J. V., Diekmann, R., Adel, M., Omar, N. M., Boraie, M. Z., Gad, S., Ries, J., Kirik, D., Nabavi, S. & Jensen, P. H., 2019, In: Acta Neuropathologica Communications. 7, 1, 213.Research output: Contribution to journal › Article › peer-review
Open Access -
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease
Baldo, B., Gabery, S., Soylu-Kucharz, R., Cheong, R. Y., Henningsen, J. B., Englund, E., McLean, C., Kirik, D., Halliday, G. & Petersén, 2019, In: Neuropathology and Applied Neurobiology. 45, 4, p. 361-379Research output: Contribution to journal › Article › peer-review
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2018
Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice
Hansen, M. G., Ledri, L. N., Kirik, D., Kokaia, M. & Ledri, M., 2018 Jan 9, In: Frontiers in Cellular Neuroscience. 11, 433.Research output: Contribution to journal › Article › peer-review
Open Access -
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein
Lillethorup, T. P., Glud, A. N., Landeck, N., Alstrup, A. K. O., Jakobsen, S., Vang, K., Doudet, D. J., Brooks, D. J., Kirik, D., Hinz, R., Sørensen, J. C. & Landau, A. M., 2018, In: Synapse. 72, 12, e22060.Research output: Contribution to journal › Article › peer-review
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Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs
Lillethorup, T. P., Glud, A. N., Alstrup, A. K. O., Noer, O., Nielsen, E. H. T., Schacht, A. C., Landeck, N., Kirik, D., Orlowski, D., Sørensen, J. C. H., Doudet, D. J. & Landau, A. M., 2018, In: Scientific Reports. 8, 1, 15715.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay
Baldo, B., Sajjad, M. U., Cheong, R. Y., Bigarreau, J., Vijayvargia, R., McLean, C., Perrier, A. L., Seong, I. S., Halliday, G., Petersén, Å. & Kirik, D., 2018, In: eNeuro. 5, 4Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates
Mandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J. & Kordower, J. H., 2017 Jun 16, In: Acta Neuropathologica Communications. 5, 1, p. 47Research output: Contribution to journal › Article › peer-review
Open Access -
Toxic effects of human and rodent variants of alpha-synuclein in vivo
Landeck, N., Buck, K. & Kirik, D., 2017 Feb 1, In: European Journal of Neuroscience. 45, 4, p. 536-547 12 p.Research output: Contribution to journal › Article › peer-review
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Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands
Kirik, D., Cederfjäll, E., Halliday, G. & Petersén, 2017 Jan 1, In: Neurobiology of Disease. 97, p. 179-188 10 p.Research output: Contribution to journal › Review article › peer-review
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Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats
Naughton, C., O'Toole, D., Kirik, D. & Dowd, E., 2017 Jan 1, In: Behavioural Brain Research. 316, p. 160-168 9 p.Research output: Contribution to journal › Article › peer-review
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2016
How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?
Volpicelli-Daley, L. A., Kirik, D., Stoyka, L. E., Standaert, D. G. & Harms, A. S., 2016 Oct 1, In: Journal of Neurochemistry. 139, S1, p. 131-155 25 p.Research output: Contribution to journal › Review article › peer-review
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A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
Landeck, N., Hall, H., Ardah, M. T., Majbour, N. K., El-Agnaf, O. M. A., Halliday, G. & Kirik, D., 2016 Aug 22, In: Molecular Neurodegeneration. 11, 1, 125.Research output: Contribution to journal › Article › peer-review
Open Access -
Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T.
Cuellar-Baena, S., Landeck, N., Sonnay, S., Buck, K., Mlynarik, V., in 't Zandt, R. & Kirik, D., 2016, In: Journal of Neurochemistry. 137, 5, p. 806-819Research output: Contribution to journal › Article › peer-review
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2015
A doctor's dilemma
Kirik, D. & Pain, E., 2015 Nov 20, In: Science (New York, N.Y.). 350, 6263, p. 998Research output: Contribution to journal › Article
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Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
Cederfjäll, E., Broom, L. & Kirik, D., 2015, In: Molecular Therapy. 23, 5, p. 896-906Research output: Contribution to journal › Article › peer-review
File178 Downloads (Pure) -
Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
Soylu, R., Adlesic, N., Baldo, B., Kirik, D. & Petersén, Å., 2015, In: Scientific Reports. 5, 14598.Research output: Contribution to journal › Article › peer-review
Open AccessFile294 Downloads (Pure) -
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.
Kuzdas-Wood, D., Fellner, L., Premstaller, M., Borm, C., Bloem, B., Kirik, D., Wenning, G. K. & Stefanova, N., 2015, In: BMC Neuroscience. 16, 1, 86.Research output: Contribution to journal › Article › peer-review
Open Access -
Selective loss of oxytocin and vasopressin in the hypothalamus in early Huntington disease: a case study.
Gabery, S., Halliday, G., Kirik, D., Englund, E. & Petersén, Å., 2015, In: Neuropathology & Applied Neurobiology. 41, 6, p. 843-848Research output: Contribution to journal › Letter › peer-review
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Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.
Buck, K., Landeck, N., Ulusoy, A., Majbour, N. K., El-Agnaf, O. M. A. & Kirik, D., 2015, In: Neurobiology of Disease. 78, Mar 25, p. 100-114Research output: Contribution to journal › Article › peer-review
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Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.
Gabery, S., Georgiou-Karistianis, N., Hult Lundh, S., Cheong, R., Churchyard, A., Chua, P., Stout, J. C., Egan, G. F., Kirik, D. & Petersén, Å., 2015, In: PLoS ONE. 10, 2, e0117593.Research output: Contribution to journal › Article › peer-review
Open AccessFile476 Downloads (Pure) -
2014
Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
Sahin, G., Thompson, L., Lavisse, S., Özgür, M., Rbah-Vidal, L., Dollé, F., Hantraye, P. & Kirik, D., 2014, In: PLoS ONE. 9, 3, e90759.Research output: Contribution to journal › Article › peer-review
File235 Downloads (Pure) -
Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.
Ledri, M., Grönning Madsen, M., Nikitidou, L., Kirik, D. & Kokaia, M., 2014, In: The Journal of Neuroscience. 34, 9, p. 3364-3377Research output: Contribution to journal › Article › peer-review
File316 Downloads (Pure) -
Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease
Moloney, T. C., Hyland, R., O'Toole, D., Paucard, A., Kirik, D., O'Doherty, A., Gorman, A. M. & Dowd, E., 2014, In: CNS Neuroscience & Therapeutics. 20, 1, p. 50-58Research output: Contribution to journal › Article › peer-review
Open Access -
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.
Hall, H., Reyes, S., Landeck, N., Bye, C., Leanza, G., Double, K., Thompson, L., Halliday, G. & Kirik, D., 2014, In: Brain. 137, Jul 24, p. 2493-2508Research output: Contribution to journal › Article › peer-review
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Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.
Berglind, F., Ledri, M., Sørensen, A. T., Nikitidou, L., Melis, M., Bielefeld, P., Kirik, D., Deisseroth, K., Andersson, M. & Kokaia, M., 2014, In: Neurobiology of Disease. 65, p. 133-141Research output: Contribution to journal › Article › peer-review
File665 Downloads (Pure) -
Twisting mice move the dystonia field forward
Petersén, Å. & Kirik, D., 2014, In: Journal of Clinical Investigation. 124, 7, p. 2848-2850Research output: Contribution to journal › Debate/Note/Editorial
File71 Downloads (Pure) -
2013
Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies
Bezard, E., Yue, Z., Kirik, D. & Spillantini, M. G., 2013, In: Movement Disorders. 28, 1, p. 61-70Research output: Contribution to journal › Review article › peer-review