Research output per year
Research output per year
Research output
- 1 - 50 out of 137 results
Search results
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2022
A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells
Moriarty, N., Gantner, C. W., Hunt, C. P. J., Ermine, C. M., Frausin, S., Viventi, S., Ovchinnikov, D. A., Kirik, D., Parish, C. L. & Thompson, L. H., 2022 Mar 3, In: Cell Stem Cell. 29, 3, p. 434-448.e5Research output: Contribution to journal › Article › peer-review
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Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks
Marciano, S., Ionescu, T. M., Saw, R. S., Cheong, R. Y., Kirik, D., Maurer, A., Pichler, B. J. & Herfert, K., 2022 Oct 4, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 40, e2122552119.Research output: Contribution to journal › Article › peer-review
Open Access -
High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping
Frantz, D., Karamahmutoglu, T., Schaser, A. J., Kirik, D. & Berrocal, E., 2022 Sep 1, In: Biomedical Optics Express. 13, 9, p. 4907-4925 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats
Tugba, E. K., Medine, G. I. O., Ozlem, A., Deniz, K. & Filiz, O. Y., 2022, In: Pharmacology Biochemistry and Behavior. 213, 173317.Research output: Contribution to journal › Article › peer-review
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2021
Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease
Huynh, B., Fu, Y., Kirik, D., Shine, J. M. & Halliday, G. M., 2021, In: Movement Disorders. 36, 9, p. 2085-2093Research output: Contribution to journal › Article › peer-review
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DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease
Arkan, S., Ljungberg, M., Kirik, D. & Hansen, C., 2021 Oct, In: Neurobiology of Disease. 158, 105477.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model
Cheong, R. Y., Baldo, B., Sajjad, M. U., Kirik, D. & Petersén, Å., 2021 Jun 1, In: Neuropathology and Applied Neurobiology. 47, 4, p. 564-578 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome
Petty, A., Cui, X., Ali, A., Du, Z., Srivastav, S., Kesby, J. P., Kirik, D., Howes, O. & Eyles, D., 2021, In: Scientific Reports. 11, 1, 4294.Research output: Contribution to journal › Article › peer-review
Open Access -
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease
Marmion, D. J., Rutkowski, A. A., Chatterjee, D., Hiller, B. M., Werner, M. H., Bezard, E., Kirik, D., McCown, T., Gray, S. J. & Kordower, J. H., 2021, In: Neurobiology of Disease. 148, 105184.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
Landeck, N., Strathearn, K. E., Ysselstein, D., Buck, K., Dutta, S., Banerjee, S., Lv, Z., Hulleman, J. D., Hindupur, J., Lin, L. K., Padalkar, S., Stanciu, L. A., Lyubchenko, Y. L., Kirik, D. & Rochet, J. C., 2020, In: Molecular Neurodegeneration. 15, 1, 49.Research output: Contribution to journal › Article › peer-review
Open Access -
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
Gantner, C. W., de Luzy, I. R., Kauhausen, J. A., Moriarty, N., Niclis, J. C., Bye, C. R., Penna, V., Hunt, C. P. J., Ermine, C. M., Pouton, C. W., Kirik, D., Thompson, L. H. & Parish, C. L., 2020, In: Cell Stem Cell. 26, 4, p. 511-526.e5Research output: Contribution to journal › Article › peer-review
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2019
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia
Petty, A., Cui, X., Tesiram, Y., Kirik, D., Howes, O. & Eyles, D., 2019, In: npj Schizophrenia. 5, 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access -
Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
Elfarrash, S., Jensen, N. M., Ferreira, N., Betzer, C., Thevathasan, J. V., Diekmann, R., Adel, M., Omar, N. M., Boraie, M. Z., Gad, S., Ries, J., Kirik, D., Nabavi, S. & Jensen, P. H., 2019, In: Acta Neuropathologica Communications. 7, 1, 213.Research output: Contribution to journal › Article › peer-review
Open Access -
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease
Baldo, B., Gabery, S., Soylu-Kucharz, R., Cheong, R. Y., Henningsen, J. B., Englund, E., McLean, C., Kirik, D., Halliday, G. & Petersén, 2019, In: Neuropathology and Applied Neurobiology. 45, 4, p. 361-379Research output: Contribution to journal › Article › peer-review
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2018
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein
Lillethorup, T. P., Glud, A. N., Landeck, N., Alstrup, A. K. O., Jakobsen, S., Vang, K., Doudet, D. J., Brooks, D. J., Kirik, D., Hinz, R., Sørensen, J. C. & Landau, A. M., 2018, In: Synapse. 72, 12, e22060.Research output: Contribution to journal › Article › peer-review
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Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs
Lillethorup, T. P., Glud, A. N., Alstrup, A. K. O., Noer, O., Nielsen, E. H. T., Schacht, A. C., Landeck, N., Kirik, D., Orlowski, D., Sørensen, J. C. H., Doudet, D. J. & Landau, A. M., 2018, In: Scientific Reports. 8, 1, 15715.Research output: Contribution to journal › Article › peer-review
Open Access -
Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice
Hansen, M. G., Ledri, L. N., Kirik, D., Kokaia, M. & Ledri, M., 2018 Jan 9, In: Frontiers in Cellular Neuroscience. 11, 433.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay
Baldo, B., Sajjad, M. U., Cheong, R. Y., Bigarreau, J., Vijayvargia, R., McLean, C., Perrier, A. L., Seong, I. S., Halliday, G., Petersén, Å. & Kirik, D., 2018, In: eNeuro. 5, 4Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats
Naughton, C., O'Toole, D., Kirik, D. & Dowd, E., 2017 Jan 1, In: Behavioural Brain Research. 316, p. 160-168 9 p.Research output: Contribution to journal › Article › peer-review
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Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates
Mandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J. & Kordower, J. H., 2017 Jun 16, In: Acta Neuropathologica Communications. 5, 1, p. 47Research output: Contribution to journal › Article › peer-review
Open Access -
Toxic effects of human and rodent variants of alpha-synuclein in vivo
Landeck, N., Buck, K. & Kirik, D., 2017 Feb 1, In: European Journal of Neuroscience. 45, 4, p. 536-547 12 p.Research output: Contribution to journal › Article › peer-review
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2016
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
Landeck, N., Hall, H., Ardah, M. T., Majbour, N. K., El-Agnaf, O. M. A., Halliday, G. & Kirik, D., 2016 Aug 22, In: Molecular Neurodegeneration. 11, 1, 125.Research output: Contribution to journal › Article › peer-review
Open Access -
Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T.
Cuellar-Baena, S., Landeck, N., Sonnay, S., Buck, K., Mlynarik, V., in 't Zandt, R. & Kirik, D., 2016, In: Journal of Neurochemistry. 137, 5, p. 806-819Research output: Contribution to journal › Article › peer-review
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2015
A doctor's dilemma
Kirik, D. & Pain, E., 2015 Nov 20, In: Science (New York, N.Y.). 350, 6263, p. 998Research output: Contribution to journal › Article
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Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
Cederfjäll, E., Broom, L. & Kirik, D., 2015, In: Molecular Therapy. 23, 5, p. 896-906Research output: Contribution to journal › Article › peer-review
File153 Downloads (Pure) -
Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
Soylu, R., Adlesic, N., Baldo, B., Kirik, D. & Petersén, Å., 2015, In: Scientific Reports. 5, 14598.Research output: Contribution to journal › Article › peer-review
Open AccessFile232 Downloads (Pure) -
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.
Kuzdas-Wood, D., Fellner, L., Premstaller, M., Borm, C., Bloem, B., Kirik, D., Wenning, G. K. & Stefanova, N., 2015, In: BMC Neuroscience. 16, 1, 86.Research output: Contribution to journal › Article › peer-review
Open Access -
Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.
Buck, K., Landeck, N., Ulusoy, A., Majbour, N. K., El-Agnaf, O. M. A. & Kirik, D., 2015, In: Neurobiology of Disease. 78, Mar 25, p. 100-114Research output: Contribution to journal › Article › peer-review
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Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.
Gabery, S., Georgiou-Karistianis, N., Hult Lundh, S., Cheong, R., Churchyard, A., Chua, P., Stout, J. C., Egan, G. F., Kirik, D. & Petersén, Å., 2015, In: PLoS ONE. 10, 2, e0117593.Research output: Contribution to journal › Article › peer-review
Open AccessFile409 Downloads (Pure) -
2014
Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
Sahin, G., Thompson, L., Lavisse, S., Özgür, M., Rbah-Vidal, L., Dollé, F., Hantraye, P. & Kirik, D., 2014, In: PLoS ONE. 9, 3, e90759.Research output: Contribution to journal › Article › peer-review
File181 Downloads (Pure) -
Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.
Ledri, M., Grönning Madsen, M., Nikitidou, L., Kirik, D. & Kokaia, M., 2014, In: Journal of Neuroscience. 34, 9, p. 3364-3377Research output: Contribution to journal › Article › peer-review
File242 Downloads (Pure) -
Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease
Moloney, T. C., Hyland, R., O'Toole, D., Paucard, A., Kirik, D., O'Doherty, A., Gorman, A. M. & Dowd, E., 2014, In: CNS Neuroscience & Therapeutics. 20, 1, p. 50-58Research output: Contribution to journal › Article › peer-review
Open Access -
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.
Hall, H., Reyes, S., Landeck, N., Bye, C., Leanza, G., Double, K., Thompson, L., Halliday, G. & Kirik, D., 2014, In: Brain. 137, Jul 24, p. 2493-2508Research output: Contribution to journal › Article › peer-review
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Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.
Berglind, F., Ledri, M., Sørensen, A. T., Nikitidou, L., Melis, M., Bielefeld, P., Kirik, D., Deisseroth, K., Andersson, M. & Kokaia, M., 2014, In: Neurobiology of Disease. 65, p. 133-141Research output: Contribution to journal › Article › peer-review
File586 Downloads (Pure) -
2013
Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration
Xilouri, M., Brekk, O. R., Landeck, N., Pitychoutis, P. M., Papasilekas, T., Papadopoulou-Daifoti, Z., Kirik, D. & Stefanis, L., 2013, In: Brain. 136, p. 2130-2146Research output: Contribution to journal › Article › peer-review
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Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors.
Hall, H., Jewett, M., Landeck, N., Nilsson, N., Schagerlöf, U., Leanza, G. & Kirik, D., 2013, In: PLoS ONE. 8, 5, e64844.Research output: Contribution to journal › Article › peer-review
Open AccessFile169 Downloads (Pure) -
Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.
Cederfjäll, E., Nilsson, N., Sahin, G., Chu, Y., Nikitidou, E., Björklund, T., Kordower, J. H. & Kirik, D., 2013, In: Scientific Reports. 3, 2157.Research output: Contribution to journal › Article › peer-review
Open AccessFile189 Downloads (Pure) -
Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntingtons disease
Hult Lundh, S., Nilsson, N., Soylu, R., Kirik, D. & Petersén, Å., 2013, In: Human Molecular Genetics. 22, 17, p. 3485-3497Research output: Contribution to journal › Article › peer-review
File184 Downloads (Pure) -
Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
Febbraro, F., Sahin, G., Farran, A., Soares, S., Jensen, P. H., Kirik, D. & Romero-Ramos, M., 2013, In: Neurobiology of Disease. 56, p. 47-58Research output: Contribution to journal › Article › peer-review
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The behavioural and neuropathological impact of intranigral AAV-alpha-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats
Mulcahy, P., O'Doherty, A., Paucard, A., O'Brien, T., Kirik, D. & Dowd, E., 2013, In: Behavioural Brain Research. 243, p. 6-15Research output: Contribution to journal › Article › peer-review
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Transduced Wild-Type but Not P301S Mutated Human Tau Shows Hyperphosphorylation in Transgenic Mice Overexpressing A30P Mutated Human Alpha-Synuclein
Oksman, M., Wisman, L., Jiang, H., Miettinen, P., Kirik, D. & Tanila, H., 2013, In: Neurodegenerative Diseases. 12, 2, p. 91-102Research output: Contribution to journal › Article › peer-review
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Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease
Reyes, S., Fu, Y., Double, K. L., Cottam, V., Thompson, L. H., Kirik, D., Paxinos, G., Watson, C., Cooper, H. M. & Halliday, G. M., 2013, In: Neurobiology of Aging. 34, 3, p. 873-886Research output: Contribution to journal › Article › peer-review
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Variability in Neuronal Expression of Dopamine Receptors and Transporters in the Substantia Nigra
Reyes, S., Cottam, V., Kirik, D., Double, K. L. & Halliday, G. M., 2013, In: Movement Disorders. 28, 10, p. 1351-1359Research output: Contribution to journal › Article › peer-review
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2012
alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
Lastres-Becker, I., Ulusoy, A., Innamorato, N. G., Sahin, G., Rabano, A., Kirik, D. & Cuadrado, A., 2012, In: Human Molecular Genetics. 21, 14, p. 3173-3192Research output: Contribution to journal › Article › peer-review
File239 Downloads (Pure) -
Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.
Ledri, M., Nikitidou, L., Erdelyi, F., Szabo, G., Kirik, D., Deisseroth, K. & Kokaia, M., 2012, In: European Journal of Neuroscience. 36, 1, p. 1971-1983Research output: Contribution to journal › Article › peer-review
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Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.
Gabery, S., Sajjad, M. U., Hult Lundh, S., Soylu, R., Kirik, D. & Petersén, Å., 2012, In: European Journal of Neuroscience. 36, 6, p. 2789-2800Research output: Contribution to journal › Article › peer-review
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Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.
Cederfjäll, E., Sahin, G., Kirik, D. & Björklund, T., 2012, In: Molecular Therapy. 20, 7, p. 1315-1326Research output: Contribution to journal › Article › peer-review
File157 Downloads (Pure) -
Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.
Mulcahy, P., O'Doherty, A., Paucard, A., O'Brien, T., Kirik, D. & Dowd, E., 2012, In: Neuroscience. 203, p. 170-179Research output: Contribution to journal › Article › peer-review
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Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue.
Hall, H., Cuellar-Baena, S., Denisov, V. & Kirik, D., 2012, In: Journal of Neurochemistry.Research output: Contribution to journal › Article › peer-review
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Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
Ulusoy, A., Björklund, T., Buck, K. & Kirik, D., 2012, In: Neurobiology of Disease. 47, 3, p. 367-377Research output: Contribution to journal › Article › peer-review