Deniz Kirik

2025

TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice

Bergh, S., Casadei, N., Gabery, S., Simonsson, O., Duarte, J. M. N., Kirik, D., Nguyen, H. P. & Petersén, Å., 2025 Dec, In: Acta Neuropathologica Communications. 13, 1, 119.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain

Trist, B. G., Wright, C. J., Rangel, A., Cottle, L., Prasad, A., Jensen, N. M., Gram, H., Dzamko, N., Jensen, P. H. & Kirik, D., 2024 Dec, In: npj Parkinson's Disease. 10, 1, 217.

Research output: Contribution to journal › Article › peer-review

Open Access

Image post-processing for SILMAS: structured illumination light sheet microscopy with axial sweeping

Frantz, D., Wright, C. J., Schaser, A. J., Kirik, D., Kristensson, E. & Berrocal, E., 2024 Aug, In: Biomedical Optics Express. 15, 8, p. 4943-4962 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Basal activity of PINK1 and PRKN in cell models and rodent brain

Watzlawik, J. O., Fiesel, F. C., Fiorino, G., Bustillos, B. A., Baninameh, Z., Markham, B. N., Hou, X., Hayes, C. S., Bredenberg, J. M., Kurchaba, N. W., Fričová, D., Siuda, J., Wszolek, Z. K., Noda, S., Sato, S., Hattori, N., Prasad, A. A., Kirik, D., Fox, H. S. & Stauch, K. L. & 2 others, Goldberg, M. S. & Springer, W., 2024, In: Autophagy. 20, 5, p. 1147-1158 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

Sastre, D., Zafar, F., Torres, C. A. M., Piper, D., Kirik, D., Sanders, L. H., Qi, L. S. & Schüle, B., 2023 Dec, In: Scientific Reports. 13, 1, 17796.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease

Bergh, S., Gabery, S., Tonetto, S., Kirik, D., Petersén, Å. & Cheong, R. Y., 2023 Apr, In: Neuropathology and Applied Neurobiology. 49, 2, e12891.

Research output: Contribution to journal › Article › peer-review

Open Access

Generation of human-induced pluripotent-stem-cell-derived cortical neurons for high-throughput imaging of neurite morphology and neuron maturation

Wali, G., Li, Y., Abu-Bonsrah, D., Kirik, D., Parish, C. L. & Sue, C. M., 2023, In: STAR Protocols. 4, 2, 102325.

Research output: Contribution to journal › Article › peer-review

Open Access

Generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene

Pavan, C., Jin, J., Jong, S., Strbenac, D., Davis, R. L., Sue, C. M., Johnston, J., Lynch, T., Halliday, G., Kirik, D., Parish, C. L., Thompson, L. H. & Ovchinnikov, D. A., 2023, In: Stem Cell Research. 73, 103211.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks

Marciano, S., Ionescu, T. M., Saw, R. S., Cheong, R. Y., Kirik, D., Maurer, A., Pichler, B. J. & Herfert, K., 2022 Oct 4, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 40, e2122552119.

Research output: Contribution to journal › Article › peer-review

Open Access

High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping

Frantz, D., Karamahmutoglu, T., Schaser, A. J., Kirik, D. & Berrocal, E., 2022 Sept 1, In: Biomedical Optics Express. 13, 9, p. 4907-4925 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells

Moriarty, N., Gantner, C. W., Hunt, C. P. J., Ermine, C. M., Frausin, S., Viventi, S., Ovchinnikov, D. A., Kirik, D., Parish, C. L. & Thompson, L. H., 2022 Mar 3, In: Cell Stem Cell. 29, 3, p. 434-448.e5

Research output: Contribution to journal › Article › peer-review

Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats

Tugba, E. K., Medine, G. I. O., Ozlem, A., Deniz, K. & Filiz, O. Y., 2022, In: Pharmacology Biochemistry and Behavior. 213, 173317.

Research output: Contribution to journal › Article › peer-review

2021

DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease

Arkan, S., Ljungberg, M., Kirik, D. & Hansen, C., 2021 Oct, In: Neurobiology of Disease. 158, 105477.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model

Cheong, R. Y., Baldo, B., Sajjad, M. U., Kirik, D. & Petersén, Å., 2021 Jun 1, In: Neuropathology and Applied Neurobiology. 47, 4, p. 564-578 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease

Huynh, B., Fu, Y., Kirik, D., Shine, J. M. & Halliday, G. M., 2021, In: Movement Disorders. 36, 9, p. 2085-2093

Research output: Contribution to journal › Article › peer-review

Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome

Petty, A., Cui, X., Ali, A., Du, Z., Srivastav, S., Kesby, J. P., Kirik, D., Howes, O. & Eyles, D., 2021, In: Scientific Reports. 11, 1, 4294.

Research output: Contribution to journal › Article › peer-review

Open Access

Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease

Marmion, D. J., Rutkowski, A. A., Chatterjee, D., Hiller, B. M., Werner, M. H., Bezard, E., Kirik, D., McCown, T., Gray, S. J. & Kordower, J. H., 2021, In: Neurobiology of Disease. 148, 105184.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

Landeck, N., Strathearn, K. E., Ysselstein, D., Buck, K., Dutta, S., Banerjee, S., Lv, Z., Hulleman, J. D., Hindupur, J., Lin, L. K., Padalkar, S., Stanciu, L. A., Lyubchenko, Y. L., Kirik, D. & Rochet, J. C., 2020, In: Molecular Neurodegeneration. 15, 1, 49.

Research output: Contribution to journal › Article › peer-review

Open Access

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

Gantner, C. W., de Luzy, I. R., Kauhausen, J. A., Moriarty, N., Niclis, J. C., Bye, C. R., Penna, V., Hunt, C. P. J., Ermine, C. M., Pouton, C. W., Kirik, D., Thompson, L. H. & Parish, C. L., 2020, In: Cell Stem Cell. 26, 4, p. 511-526.e5

Research output: Contribution to journal › Article › peer-review

2019

Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia

Petty, A., Cui, X., Tesiram, Y., Kirik, D., Howes, O. & Eyles, D., 2019, In: npj Schizophrenia. 5, 1, 6.

Research output: Contribution to journal › Article › peer-review

Open Access

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Elfarrash, S., Jensen, N. M., Ferreira, N., Betzer, C., Thevathasan, J. V., Diekmann, R., Adel, M., Omar, N. M., Boraie, M. Z., Gad, S., Ries, J., Kirik, D., Nabavi, S. & Jensen, P. H., 2019, In: Acta Neuropathologica Communications. 7, 1, 213.

Research output: Contribution to journal › Article › peer-review

Open Access

SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease

Baldo, B., Gabery, S., Soylu-Kucharz, R., Cheong, R. Y., Henningsen, J. B., Englund, E., McLean, C., Kirik, D., Halliday, G. & Petersén, 2019, In: Neuropathology and Applied Neurobiology. 45, 4, p. 361-379

Research output: Contribution to journal › Article › peer-review

2018

Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice

Hansen, M. G., Ledri, L. N., Kirik, D., Kokaia, M. & Ledri, M., 2018 Jan 9, In: Frontiers in Cellular Neuroscience. 11, 433.

Research output: Contribution to journal › Article › peer-review

Open Access

In vivo quantification of glial activation in minipigs overexpressing human α-synuclein

Lillethorup, T. P., Glud, A. N., Landeck, N., Alstrup, A. K. O., Jakobsen, S., Vang, K., Doudet, D. J., Brooks, D. J., Kirik, D., Hinz, R., Sørensen, J. C. & Landau, A. M., 2018, In: Synapse. 72, 12, e22060.

Research output: Contribution to journal › Article › peer-review

Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs

Lillethorup, T. P., Glud, A. N., Alstrup, A. K. O., Noer, O., Nielsen, E. H. T., Schacht, A. C., Landeck, N., Kirik, D., Orlowski, D., Sørensen, J. C. H., Doudet, D. J. & Landau, A. M., 2018, In: Scientific Reports. 8, 1, 15715.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

Baldo, B., Sajjad, M. U., Cheong, R. Y., Bigarreau, J., Vijayvargia, R., McLean, C., Perrier, A. L., Seong, I. S., Halliday, G., Petersén, Å. & Kirik, D., 2018, In: eNeuro. 5, 4

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Mandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J. & Kordower, J. H., 2017 Jun 16, In: Acta Neuropathologica Communications. 5, 1, p. 47

Research output: Contribution to journal › Article › peer-review

Open Access

Toxic effects of human and rodent variants of alpha-synuclein in vivo

Landeck, N., Buck, K. & Kirik, D., 2017 Feb 1, In: European Journal of Neuroscience. 45, 4, p. 536-547 12 p.

Research output: Contribution to journal › Article › peer-review

Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats

Naughton, C., O'Toole, D., Kirik, D. & Dowd, E., 2017 Jan 1, In: Behavioural Brain Research. 316, p. 160-168 9 p.

Research output: Contribution to journal › Article › peer-review

2016

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein

Landeck, N., Hall, H., Ardah, M. T., Majbour, N. K., El-Agnaf, O. M. A., Halliday, G. & Kirik, D., 2016 Aug 22, In: Molecular Neurodegeneration. 11, 1, 125.

Research output: Contribution to journal › Article › peer-review

Open Access

Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T.

Cuellar-Baena, S., Landeck, N., Sonnay, S., Buck, K., Mlynarik, V., in 't Zandt, R. & Kirik, D., 2016, In: Journal of Neurochemistry. 137, 5, p. 806-819

Research output: Contribution to journal › Article › peer-review

2015

A doctor's dilemma

Kirik, D. & Pain, E., 2015 Nov 20, In: Science (New York, N.Y.). 350, 6263, p. 998

Research output: Contribution to journal › Article

Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.

Cederfjäll, E., Broom, L. & Kirik, D., 2015, In: Molecular Therapy. 23, 5, p. 896-906

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Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.

Soylu, R., Adlesic, N., Baldo, B., Kirik, D. & Petersén, Å., 2015, In: Scientific Reports. 5, 14598.

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Open Access

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Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.

Kuzdas-Wood, D., Fellner, L., Premstaller, M., Borm, C., Bloem, B., Kirik, D., Wenning, G. K. & Stefanova, N., 2015, In: BMC Neuroscience. 16, 1, 86.

Research output: Contribution to journal › Article › peer-review

Open Access

Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.

Buck, K., Landeck, N., Ulusoy, A., Majbour, N. K., El-Agnaf, O. M. A. & Kirik, D., 2015, In: Neurobiology of Disease. 78, Mar 25, p. 100-114

Research output: Contribution to journal › Article › peer-review

Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.

Gabery, S., Georgiou-Karistianis, N., Hult Lundh, S., Cheong, R., Churchyard, A., Chua, P., Stout, J. C., Egan, G. F., Kirik, D. & Petersén, Å., 2015, In: PLoS ONE. 10, 2, e0117593.

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Open Access

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2014

Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease.

Sahin, G., Thompson, L., Lavisse, S., Özgür, M., Rbah-Vidal, L., Dollé, F., Hantraye, P. & Kirik, D., 2014, In: PLoS ONE. 9, 3, e90759.

Research output: Contribution to journal › Article › peer-review

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Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

Ledri, M., Grönning Madsen, M., Nikitidou, L., Kirik, D. & Kokaia, M., 2014, In: The Journal of Neuroscience. 34, 9, p. 3364-3377

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Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease

Moloney, T. C., Hyland, R., O'Toole, D., Paucard, A., Kirik, D., O'Doherty, A., Gorman, A. M. & Dowd, E., 2014, In: CNS Neuroscience & Therapeutics. 20, 1, p. 50-58

Research output: Contribution to journal › Article › peer-review

Open Access

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.

Hall, H., Reyes, S., Landeck, N., Bye, C., Leanza, G., Double, K., Thompson, L., Halliday, G. & Kirik, D., 2014, In: Brain. 137, Jul 24, p. 2493-2508

Research output: Contribution to journal › Article › peer-review

Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

Berglind, F., Ledri, M., Sørensen, A. T., Nikitidou, L., Melis, M., Bielefeld, P., Kirik, D., Deisseroth, K., Andersson, M. & Kokaia, M., 2014, In: Neurobiology of Disease. 65, p. 133-141

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2013

Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration

Xilouri, M., Brekk, O. R., Landeck, N., Pitychoutis, P. M., Papasilekas, T., Papadopoulou-Daifoti, Z., Kirik, D. & Stefanis, L., 2013, In: Brain. 136, p. 2130-2146

Research output: Contribution to journal › Article › peer-review

Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors.

Hall, H., Jewett, M., Landeck, N., Nilsson, N., Schagerlöf, U., Leanza, G. & Kirik, D., 2013, In: PLoS ONE. 8, 5, e64844.

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Open Access

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Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

Cederfjäll, E., Nilsson, N., Sahin, G., Chu, Y., Nikitidou, E., Björklund, T., Kordower, J. H. & Kirik, D., 2013, In: Scientific Reports. 3, 2157.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntingtons disease

Hult Lundh, S., Nilsson, N., Soylu, R., Kirik, D. & Petersén, Å., 2013, In: Human Molecular Genetics. 22, 17, p. 3485-3497

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Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

Febbraro, F., Sahin, G., Farran, A., Soares, S., Jensen, P. H., Kirik, D. & Romero-Ramos, M., 2013, In: Neurobiology of Disease. 56, p. 47-58

Research output: Contribution to journal › Article › peer-review

The behavioural and neuropathological impact of intranigral AAV-alpha-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats

Mulcahy, P., O'Doherty, A., Paucard, A., O'Brien, T., Kirik, D. & Dowd, E., 2013, In: Behavioural Brain Research. 243, p. 6-15

Research output: Contribution to journal › Article › peer-review

Transduced Wild-Type but Not P301S Mutated Human Tau Shows Hyperphosphorylation in Transgenic Mice Overexpressing A30P Mutated Human Alpha-Synuclein

Oksman, M., Wisman, L., Jiang, H., Miettinen, P., Kirik, D. & Tanila, H., 2013, In: Neurodegenerative Diseases. 12, 2, p. 91-102

Research output: Contribution to journal › Article › peer-review

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

Reyes, S., Fu, Y., Double, K. L., Cottam, V., Thompson, L. H., Kirik, D., Paxinos, G., Watson, C., Cooper, H. M. & Halliday, G. M., 2013, In: Neurobiology of Aging. 34, 3, p. 873-886

Research output: Contribution to journal › Article › peer-review

Deniz Kirik

Research output

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