Research output per year
Research output per year
Personal profile
Research
PhD Student within the Islet Cell Exocytosis group. The thesis project is focused on studying the underlying mechanisms of beta and alpha cell dysfunction observed in cystic fibrosis related diabetes. Mainly, putative paracrine signals in the form of exosomal microRNA from exocrine to endocrine cells, and the resulting effects on functions such as hormone secretion will be assessed.
Research
PhD Student within the Islet Cell Exocytosis group. The thesis project is focused on studying the underlying mechanisms of beta and alpha cell dysfunction observed in cystic fibrosis related diabetes. Mainly, putative paracrine signals in the form of exosomal microRNA from exocrine to endocrine cells, and the resulting effects on functions such as hormone secretion will be assessed.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion
Westholm, E., Karagiannopoulos, A., Kattner, N., Al-Selwi, Y., Merces, G., Shaw, J. A., Wendt, A. & Eliasson, L., 2024 Aug 19, In: iScience. 27, 9, 110767.Research output: Contribution to journal › Article › peer-review
Open Access -
MicroRNA 29 modulates β-cell mitochondrial metabolism and insulin secretion via underlying miR-29-OXPHOS complex pathways
Cowan, E., Sun, J., Hamilton, A., Ruhrmann, S., Karagiannopoulos, A., Westholm, E., Ofori, J. K., Luan, C., Zhang, E., Mulder, H. & Eliasson, L., 2024 Aug, In: Acta Physiologica. 240, 8, e14180.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulation of insulin secretion by local and circulating factors - Investigations on islet proteins and microRNAs
Westholm, E., 2024, Lund: Lund University, Faculty of Medicine. 83 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile121 Downloads (Pure) -
Glucocorticoid-mediated induction of ZBTB16 affects insulin secretion in human islets and EndoC-βH1 β-cells
Karagiannopoulos, A., Westholm, E., Ofori, J. K., Cowan, E., Esguerra, J. L. S. & Eliasson, L., 2023 May 19, In: iScience. 26, 5, p. 1-23 106555.Research output: Contribution to journal › Article › peer-review
Open Access -
Interleukin-4 reduces insulin secretion in human islets from healthy but not type-2 diabetic donors
Westholm, E., Edlund, A., Karagiannopoulos, A., Wendt, A. & Eliasson, L., 2023 Mar 15, In: Biochemical and Biophysical Research Communications. 649, p. 87-92 6 p.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Finished
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MicroRNA regulation of Alpha cell function
Westholm, E. (Researcher), Eliasson, L. (Supervisor), Karagiannopoulos, A. (Research student) & Wendt, A. (Assistant supervisor)
2020/09/01 → 2023/08/31
Project: Dissertation
Activities
- 1 Presentation
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Insulin-like growth factor binding protein 7 reduces glucose stimulated insulin secretion and downregulates key beta cell transcription factors
Westholm, E. (Role not specified)
2022 Sept 21Activity: Talk or presentation › Presentation