Personal profile
Research
I am an internal-medicine resident and post-doctoral fellow in the Perinatal and Cardiovascular Epidemiology (PACE) group at Lund University, directed by Associate Professor Simon Timpka. Working closely with Associate Professor Sofia Enhörning, I investigate endocrine and hydration-related determinants of cardiometabolic risk. I integrate untargeted and targeted mass-spectrometry metabolomics with longitudinal cohort data and controlled-hydration studies to determine (i) how melatonin secretion modulates glucose homeostasis and (ii) how chronic under-hydration, indexed by vasopressin–copeptin activity, reprograms metabolism and heightens susceptibility to type 2 diabetes and cardiovascular disease.
During my PhD in Professor Olle Melander’s Cardiovascular Research–Hypertension unit, I analysed data from more than 6,000 Malmö-cohort participants and demonstrated that diet-derived metabolic signatures predict atrial fibrillation, type 2 diabetes, cardiovascular events, and mortality. I also showed that a short Mediterranean-style dietary intervention rapidly remodels the circulating metabolome. I now apply the analytical frameworks and nutritional biomarker panels developed in that work to identify modifiable hormonal and hydration targets for the precision prevention of cardiometabolic disorders.
I welcome collaborative opportunities that advance this research agenda.
Subject classification (UKÄ)
- Epidemiology
- Medical Biostatistics
- Endocrinology and Diabetes
- Internal Medicine
Free keywords
- melatonin
- diabetes
- metabolomics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
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Nocturnal melatonin secretion and risk of type 2 diabetes: a prospective cohort study
Sojakka Smith, E., Franzén, A., Pihlsgård, M., Nilsson, P. M., Timpka, S. & Enhörning, S., 2026 May 19, In: The Journal of clinical endocrinology and metabolism. 111, 6, p. 1705-1712Research output: Contribution to journal › Article › peer-review
Open Access -
Urbanisation-associated shifts in the avian metabolome within the annual cycle
Watson, H., Nilsson, J. Å., Smith, E., Ottosson, F., Melander, O., Hegemann, A., Urhan, U. & Isaksson, C., 2024 Sept, In: Science of the Total Environment. 944, 173624.Research output: Contribution to journal › Article › peer-review
Open Access -
Impact of a short-term Mediterranean diet intervention on plasma metabolites: a pilot study
Smith, E., Ottosson, F., Ericson, U., Hellstrand, S., Rizzo, M., Sukruang, K., Pizza, V., Orho-Melander, M., Nilsson, P. M., Kennbäck, C., Fernandez, C., Antonini, P., Di Somma, S. & Melander, O., 2024 Aug, In: Metabolomics. 20, 4, 82.Research output: Contribution to journal › Article › peer-review
Open Access -
Metabolite Alterations and Cardiometabolic Disease: A Nutritional Perspective
Smith, E., 2024, Lund: Lund University, Faculty of Medicine. 72 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile367 Downloads (Pure) -
A healthy dietary metabolic signature is associated with a lower risk for type 2 diabetes and coronary artery disease
Smith, E., Ericson, U., Hellstrand, S., Orho-Melander, M., Nilsson, P. M., Fernandez, C., Melander, O. & Ottosson, F., 2022 Dec, In: BMC Medicine. 20, 1, 122.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active
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Hydration status and seasonal environmental stressors in cardiometabolic and pregrancy related disease
Franzén, A. (Research student), Enhörning, S. (Supervisor), Timpka, S. (Assistant supervisor) & Sojakka Smith, E. (Assistant supervisor)
2024/11/04 → …
Project: Dissertation
Prizes and Distinction
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Swedish Savings Bank Foundation master thesis award
Smith, E. (Recipient), 2019 Aug 26
Prize: Prize (including medals and awards)