Research output per year
Research output per year
Personal profile
Research
Overall research aims are to identify microRNAs (miRNAs) and Apolipoprotein A-I (ApoA-I) pathways relevant for prevention/treatment of type 2 diabetes.
miRNAs
- Investigating miRNAs regulating genes important in mitochondrial processes and the impact of changes in their expression on pancreatic β-cell function.
- Using in vivo models of type 2 diabetes to assess effects of miRNA inhibitors.
- Globally profiling miRNAs in human pancreatic islet cells.
ApoA-I
- Delineating ApoA-I -receptor pathways/mechanisms of insulin secretion in pancreatic β-cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Subject classification (UKÄ)
- Medical and Health Sciences
- Endocrinology and Diabetes
- Cell and Molecular Biology
- Bioinformatics (Computational Biology)
Free keywords
- Type 2 diabetes
- Islets of Langerhans
- Beta cells
- Metabolism
- Mitochondria
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Apolipoprotein A-I priming via SR-BI and ABCA1 receptor binding upregulates mitochondrial metabolism to promote insulin secretion in INS-1E cells
Lyons, C. L., Cowan, E., Nilsson, O., Mohar, M., Peña-Martínez, P., Eliasson, L. & Lagerstedt, J. O., 2024 Nov, In: PLoS ONE. 19, 11 November, e0311039.Research output: Contribution to journal › Article › peer-review
Open Access -
MicroRNA 29 modulates β-cell mitochondrial metabolism and insulin secretion via underlying miR-29-OXPHOS complex pathways
Cowan, E., Sun, J., Hamilton, A., Ruhrmann, S., Karagiannopoulos, A., Westholm, E., Ofori, J. K., Luan, C., Zhang, E., Mulder, H. & Eliasson, L., 2024 Aug, In: Acta Physiologica. 240, 8, e14180.Research output: Contribution to journal › Article › peer-review
Open Access -
RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine
Miskelly, M. G., Lindqvist, A., Piccinin, E., Hamilton, A., Cowan, E., Nergård, B. J., Del Giudice, R., Ngara, M., Cataldo, L. R., Kryvokhyzha, D., Volkov, P., Engelking, L., Artner, I., Lagerstedt, J. O., Eliasson, L., Ahlqvist, E., Moschetta, A., Hedenbro, J. & Wierup, N., 2024, In: Diabetologia. 67, 2, p. 356–370 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Glucocorticoid-mediated induction of ZBTB16 affects insulin secretion in human islets and EndoC-βH1 β-cells
Karagiannopoulos, A., Westholm, E., Ofori, J. K., Cowan, E., Esguerra, J. L. S. & Eliasson, L., 2023 May 19, In: iScience. 26, 5, p. 1-23 106555.Research output: Contribution to journal › Article › peer-review
Open Access -
miRNAs in the beta cell - friends or foes?
Karagiannopoulos, A., Cowan, E. & Eliasson, L., 2023, In: Endocrinology. 164, 5Research output: Contribution to journal › Review article › peer-review