Research output per year
Research output per year
Personal profile
Research
My research focuses in identify targetable mechanisms and pathways underlying initiation and progression of diabetic complications with potential therapeutic value.
In have investigated and successfully published a study in which we looked at whether the calcium-calcineurin transcription factor NFAT was involved in diabetic-driven endothelial and kidney dysfunction in the novel Akita mouse model of diabetes type 1.
The project that I am working at the moment focuses on exploring if the blockade of diabetes induced NFAT activation in the heart of the Akita mouse model exerts cardioprotective effects against the development of diabetic cardiomyopathy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Medical and Health Sciences
Free keywords
- Diabetes
- kidney disease
- endothelial function
- NFAT
- inflammation
- diabetic complications
- Cardiomyopathy
- vascular physiology
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Collaborations and top research areas from the last five years
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Impact of metabolic substrate modification on myocardial efficiency in a rat model of obesity and diabetes
Virta, J., Silvola, J. M. U., Kiugel, M., Liljenback, H., Berglund, L., Garcia Vaz, E., Dutius Andersson, A-M., Zetterqvist, A., Oikonen, V., Jauhianen, M., Knuuti, J., Nuutila, P., Roivainen, A., Gomez, M. F. & Saraste, A., 2022 Oct 3, In: European Heart Journal, Supplement. 43, 2, p. 3076 1 p.Research output: Contribution to journal › Published meeting abstract › peer-review
Open Access -
Inhibition of NFAT signaling restores microvascular endothelial function in diabetic mice
Garcia-Vaz, E., McNeilly, A. D., Berglund, L. M., Ahmad, A., Gallagher, J. R., Andersson, A. M. D., McCrimmon, R. J., Zetterqvist, A. V., Gomez, M. F. & Khan, F., 2020, In: Diabetes. 69, 3, p. 424-435 12 p.Research output: Contribution to journal › Article › peer-review
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MicroRNA-dependent regulation of KLF4 by glucose in vascular smooth muscle
Hien, T. T., Garcia-Vaz, E., Stenkula, K. G., Sjögren, J., Nilsson, J., Gomez, M. F. & Albinsson, S., 2018, In: Journal of Cellular Physiology. 233, 9, p. 7195-7205Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Downloads (Pure) -
Orai channels are critical for receptor-mediated endocytosis of albumin
Zeng, B., Chen, G. L., Garcia-Vaz, E., Bhandari, S., Daskoulidou, N., Berglund, L. M., Jiang, H., Hallett, T., Zhou, L. P., Huang, L., Xu, Z. H., Nair, V., Nelson, R. G., Ju, W., Kretzler, M., Atkin, S. L., Gomez, M. F. & Xu, S. Z., 2017 Dec 1, In: Nature Communications. 8, 1, 1920.Research output: Contribution to journal › Article › peer-review
Open Access -
The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model
Lindqvist, A., Ekelund, M., Garcia-Vaz, E., Ståhlman, M., Pierzynowski, S., Gomez, M. F., Rehfeld, J. F., Groop, L., Hedenbro, J., Wierup, N. & Spégel, P., 2017 Mar 1, In: PLoS ONE. 12, 3, e0173137.Research output: Contribution to journal › Article › peer-review
Open Access
Activities
- 1 Organisation of conference
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Diabetes research day
Ulrika Krus (Organiser), Ulrika Blom-Nilsson (Organiser), Peter Spégel (Organiser), Timo Otonkoski (Invited speaker), Sofia Enhörning (Invited speaker), Eliana Garcia Vaz (Invited speaker), Charlotte Ling (Invited speaker), Olof Asplund (Invited speaker) & Florentina Negoita (Invited speaker)
2016 Feb 9Activity: Participating in or organising an event › Organisation of conference