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Research

I am a geobiologist curious about the diversification of animals on Earth, an event we know very little about. Tumors may reveal clues to animal evolution, since they so well manage the leap from unicellularity to multicellularity. Animals are one of the most successful versions of multicellular organisms on Earth, but their rise remains enigmatic. Animals evolved late in Earth history (after ~85% of its current time had passed) and then their diversification was dramatic. Why? We do not understand this dramatic event and explore it primarily through clues preserved in the geological record, such as chemical or visible fossils. The geological record, however, struggles with its fragmented evidence, low resolution and its inability to shed light on causality between observations (what of the evidence that actually represents cause and effects). Therefore, we use tumors as a model for animal evolution to get at the mechanisms that were fundamental for tissue maintenance in an evolutionary perspective. These mechanisms likely still remain fundamental for tissue maintenance, whether or not the tissue is malignant or non-transformed. An evolutionary view on tissue management, therefore, can also assist us in understanding the development of tumors.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 13 - Climate Action
  • SDG 14 - Life Below Water
  • SDG 15 - Life on Land

UKÄ subject classification

  • Geosciences, Multidisciplinary
  • Evolutionary Biology
  • Cell and Molecular Biology
  • Cancer and Oncology

Free keywords

  • developmental biology
  • geobiology
  • differentiation
  • stemness
  • HIF
  • animal evolution

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