Eva Degerman

Eva Degerman


Personal profile


Our goal is to identify mechanisms that are relevant in the context of insulin resistance and diabetes / diabetes complications. After having had a focus on cellular signaling in the context of adipose tissue and diabetes for many years, we now focus on the inner ear, the organ of hearing and balance, many studies show namely a connection between diabetes and impaired inner ear function. At the cellular level we explore signaling systems, with the focus on the cAMP / cGMP-degrading enzymes (PDEs) and insulin signaling pathways. Insulin-mediated activation of a specific PDE, PDE3B, mediates the ability of insulin to inhibit the breakdown of fat, a key function in energy metabolism. We have recently shown that several PDEs, the insulin receptor and the insulin-sensitive glucose-transporter GLUT4 are expressed in inner ear sensory epithelia and now we wants to examine in more detail the role of these systems to understand the molecular connection between diabetes and inner ear dysfunction using cell and animal models and also performing clinical research.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Medical and Health Sciences
  • Cell and Molecular Biology
  • Endocrinology and Diabetes

Free keywords

  • Diabetes
  • Inner ear
  • insulin resistance
  • hearing impairment
  • Vestibular


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Collaborations the last five years

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