Research output per year
Research output per year
Personal profile
Research
Our goal is to identify mechanisms that are relevant in the context of insulin resistance and diabetes / diabetes complications. After having had a focus on cellular signaling in the context of adipose tissue and diabetes for many years, we now focus on the inner ear, the organ of hearing and balance, many studies show namely a connection between diabetes and impaired inner ear function. At the cellular level we explore signaling systems, with the focus on the cAMP / cGMP-degrading enzymes (PDEs) and insulin signaling pathways. Insulin-mediated activation of a specific PDE, PDE3B, mediates the ability of insulin to inhibit the breakdown of fat, a key function in energy metabolism. We have recently shown that several PDEs, the insulin receptor and the insulin-sensitive glucose-transporter GLUT4 are expressed in inner ear sensory epithelia and now we wants to examine in more detail the role of these systems to understand the molecular connection between diabetes and inner ear dysfunction using cell and animal models and also performing clinical research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Subject classification (UKÄ)
- Medical and Health Sciences
- Cell and Molecular Biology
- Endocrinology and Diabetes
Free keywords
- Diabetes
- Inner ear
- insulin resistance
- hearing impairment
- Vestibular
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Modulation of the sodium-chloride cotransporter by insulin in auditory cells: A potential link to diabetes-related hearing complications
Pålbrink, A. K., Magnusson, M. & Degerman, E., 2025 Sept, In: Journal of Diabetes and its Complications. 39, 9, 109111.Research output: Contribution to journal › Article › peer-review
Open Access -
Betahistine prevents development of endolymphatic hydrops in a mouse model of insulin resistance and diabetes
Pålbrink, A.-K., In 't Zandt, R., Magnusson, M. & Degerman, E., 2023, In: Acta Oto-Laryngologica. 143, 2, p. 127-133Research output: Contribution to journal › Article › peer-review
Open Access -
AMPKβ isoform expression patterns in various adipocyte models and in relation to body mass index
Kopietz, F., Degerman, E. & Göransson, O., 2022 Aug 4, In: Frontiers in Physiology. 13, 928964.Research output: Contribution to journal › Article › peer-review
Open Access -
Overexpressed beta cell CART increases insulin secretion in mouse models of insulin resistance and diabetes
Abels, M., Riva, M., Shcherbina, L., Fischer, A. H. T., Banke, E., Degerman, E., Lindqvist, A. & Wierup, N., 2022 May 1, In: Peptides. 151, 170747.Research output: Contribution to journal › Article › peer-review
Open Access -
Insulin regulates Nedd4-2 via a PKB-dependent mechanism in HEI-OC1 auditory cells-crosstalks with sphingolipid and cAMP signaling
Pålbrink, A.-K., Morén, B., Stenkula, K. G., Magnusson, M. & Degerman, E., 2022, In: Acta Oto-Laryngologica. 142, 1, p. 6-12 7 p.Research output: Contribution to journal › Article › peer-review
Open Access
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The inner ear as a target organ for insulin action and resistance
Degerman, E. (PI), Holmén-Pålbrink, A.-K. (Researcher), In 't Zandt, R. (Researcher) & Magnusson, M. (Researcher)
Novo Nordisk Foundation, Dir Albert Påhlssons stiftelse för forskning och välgörenhet, Diabetesfonden - Stiftelsen Svenska Diabetesförbundets Forskningsfond, Swedish Research Council, Diabetes Wellness Network Sweden, Insamlingsstiftelsen
2020/01/01 → 2027/12/31
Project: Research
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AMP-activated protein kinase in adipose tissue
Göransson, O. (Supervisor), Kopietz, F. (Research student), Lindahl, M. (Research engineer) & Degerman, E. (Assistant supervisor)
2017/04/01 → 2021/05/01
Project: Dissertation
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AFC: ANTIDIABETIC FOOD CENTRE
Adlercreutz, P. (PI), Ahrén, I. L. (PI), Ahrné, S. (Researcher), Alhamimi, S. (Research student), Andersson, K. E. (Researcher), Andersson, K. E. (Research student), Månberger, A. (Researcher), Axling, U. (Researcher), Axling, U. (Research student), Bergenståhl, B. (Researcher), Berger, K. (PI), Björck, I. (PI), Bränning, C. (Research student), Bäckhed, F. (PI), Zanzer, Y. C. (Research student), Danielsson, A. (PI), Danielsson, B. (Research assistant), Degerman, E. (PI), Dejmek, P. (Researcher), Dey, E. (PI), Dougkas, A. (Researcher), Ekström, L. (Research student), Eliasson, A.-C. (PI), Fahlgren, C. (Research engineer), Falck, P. (PI), Falck, P. (Research student), Ghaffarzadegan, T. (Research student), Granfeldt, Y. (Researcher), Grey, C. (Researcher), Gunnerud, U. (Research student), Håkansson, Å. (Researcher), Håkansson, Å. (Research student), Hållenius, F. (Researcher), Hållenius, F. (PI), Haskå, L. (PI), Haskå, L. (Research student), Heimann, E. (Research student), Hellstrand, P. (Researcher), Heyman, L. (Research student), Holm Wallenberg, C. (PI), Holmén-Pålbrink, A.-K. (Research assistant), Holst, O. (Researcher), Immerstrand, T. (Research student), Immerzeel, P. (Researcher), Jakobsdottir, G. (Research student), Jeppsson, B. (Researcher), Johansson, E. (Research student), Johansson, M. (Project coordinator), Johansson, M. (Researcher), Johansson, M. (Research assistant), Johansson, U. (Researcher), Jones, H. (Researcher), Nordberg Karlsson, E. (Researcher), Kovatcheva-Datchary, P. (Researcher), Kulcinskaja, E. (Research student), Landin-Olsson, M. (Researcher), Linninge, C. (Researcher), Marefati, A. (Research student), Marungruang, N. (Research student), Molin, G. (PI), Nilsson, A. (PI), Nilsson, E. (Research engineer), Nilsson, U. (PI), Nyman, M. (PI), Ohlson, E. (Research assistant), Olsson, C. (Researcher), Öste, R. (PI), Östman, E. (PI), Persson, L. (Research engineer), Persson, S. (Researcher), Plaza, M. (Researcher), Prykhodko, O. (Researcher), Radeborg, K. (Researcher), Rayner, M. (PI), Rosén, L. (Research student), Sandahl, M. (Researcher), Sandberg, J. (Research student), Sjöö, M. (PI), Skog, K. (Researcher), Spégel, P. (PI), Stålbrand, H. (Researcher), Sterner, O. (PI), Svensson, J. (Research student), Tareke, E. (PI), Tovar, J. (PI), Turner, C. (PI), Weström, B. (Researcher), Xu, J. (Research student) & Zhong, Y. (Research student)
2007/07/01 → 2018/01/31
Project: Research
Activities
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Post Graduate Course in Diabetes Research, November 2021
Degerman, E. (Role not specified)
2021 Oct 27Activity: Talk or presentation › Public lecture/debate/seminar
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chairman of a dissertation
Degerman, E. (Role not specified)
2021 Oct 26Activity: Examination and supervision › Supervision of PhD students
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PhD co-supervision
Degerman, E. (Role not specified)
2021 Oct 1 → 2025 Oct 1Activity: Examination and supervision › Supervision of PhD students
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PhD co-supervision
Degerman, E. (Role not specified)
2021 May 12Activity: Examination and supervision › Supervision of PhD students
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Diabeteskväll, SUS Malmö 24 april 2019
Fex, M. (Chair), Löndahl, M. (Invited speaker), Salehi, S. A. (Role not specified), Dunér, P. (Invited speaker), Degerman, E. (Role not specified) & Liedholm, S. (Organiser)
2019 Apr 24Activity: Participating in or organising an event › Organisation of public lecture/debate/seminar