Research output per year
Research output per year
- 39 results
Search results
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2023
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Cheng, F., Hansson, V. C., Georgolopoulos, G. & Mani, K., 2023, In: Oncotarget. 14, 1, p. 219-235 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells
Cheng, F., Fransson, L. Å. & Mani, K., 2023 Apr 1, In: Glycobiology. 33, 4, p. 325-341 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Complex modulation of cytokine-induced α-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells
Cheng, F., Fransson, L. Å. & Mani, K., 2022 Apr 1, In: Glycobiology. 32, 4, p. 333-342Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1
Cheng, F., Fransson, L. Å. & Mani, K., 2021 Aug 7, In: Glycobiology. 31, 7, p. 800-811 12 p.Research output: Contribution to journal › Article › peer-review
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2020
Proinflammatory cytokines induce accumulation of glypican-1-derived heparan sulfate and the C-terminal fragment of β-cleaved APP in autophagosomes of dividing neuronal cells
Cheng, F., Fransson, L. Å. & Mani, K., 2020, In: Glycobiology. 30, 8, p. 539-549 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
The cyanobacterial neurotoxin β-N-methylamino-L-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells
Cheng, F., Fransson, L. Å. & Mani, K., 2019, In: Experimental Cell Research. 379, 2, p. 172-181 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Common traffic routes for imported spermine and endosomal glypican-1-derived heparan sulfate in fibroblasts
Cheng, F., Fransson, L. Å. & Mani, K., 2018, In: Experimental Cell Research. 364, 2, p. 133-142Research output: Contribution to journal › Article › peer-review
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2017
Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1
Cheng, F., Fransson, L. Å. & Mani, K., 2017, In: Experimental Cell Research. 360, 2, p. 171-179Research output: Contribution to journal › Article › peer-review
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Nucleolin is a nuclear target of heparan sulfate derived from glypican-1
Cheng, F., Belting, M., Fransson, L. Å. & Mani, K., 2017, In: Experimental Cell Research. 354, 1, p. 31-39Research output: Contribution to journal › Article › peer-review
Open AccessFile185 Downloads (Pure) -
2016
Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.
Cheng, F., Bourseau-Guilmain, E., Belting, M., Fransson, L-Å. & Mani, K., 2016, In: Glycobiology. 26, 6, p. 623-634 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile429 Downloads (Pure) -
2015
Rapid nuclear transit and impaired degradation of amyloid beta and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.
Cheng, F., Fransson, L-Å. & Mani, K., 2015, In: Glycobiology. 25, 5, p. 548-556Research output: Contribution to journal › Article › peer-review
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Suppression of glypican-1 autodegradation by NO-deprivation correlates with nuclear accumulation of amyloid beta in normal fibroblasts.
Cheng, F., Fransson, L-Å. & Mani, K., 2015, In: Glycoconjugate Journal. 32, 9, p. 675-684Research output: Contribution to journal › Article › peer-review
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2014
APP/APLP2 expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.
Cheng, F., Cappai, R., Lidfeldt, J., Belting, M., Fransson, L-Å. & Mani, K., 2014, In: Journal of Biological Chemistry. 289, 30, p. 20871-20878Research output: Contribution to journal › Article › peer-review
File142 Downloads (Pure) -
2013
Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products
Cheng, F., Ruscher, K., Fransson, L-Å. & Mani, K., 2013, In: Glycobiology. 23, 12, p. 1510-1519Research output: Contribution to journal › Article › peer-review
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2012
Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage.
Cheng, F., Svensson Birkedal, G., Fransson, L-Å. & Mani, K., 2012, In: Glycobiology. 22, 11, p. 1480-1485Research output: Contribution to journal › Article › peer-review
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2011
Suppression of amyloid beta a11-immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, no-catalyzed degradation.
Cheng, F., Cappai, R., Ciccotosto, G. D., Svensson Birkedal, G., Multhaup, G., Fransson, L-Å. & Mani, K., 2011, In: Journal of Biological Chemistry. 286, 31, p. 27559-27572Research output: Contribution to journal › Article › peer-review
File114 Downloads (Pure) -
2009
Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.
Cheng, F., Johnsson, R., Nilsson, J., Fransson, L-Å., Ellervik, U. & Mani, K., 2009, In: Cancer Letters. 273, p. 148-154Research output: Contribution to journal › Article › peer-review
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2008
Involvement of glypican-1 autoprocessing in scrapie infection
Lofgren, K., Cheng, F., Fransson, L-Å., Bedecs, K. & Mani, K., 2008, In: European Journal of Neuroscience. 28, 5, p. 964-972Research output: Contribution to journal › Article › peer-review
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2007
Heparan sulfate degradation products can associate with oxidized proteins and proteasomes.
Mani, K., Cheng, F. & Fransson, L-Å., 2007, In: Journal of Biological Chemistry. 282, 30, p. 21934-21944Research output: Contribution to journal › Article › peer-review
Open Access -
HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.
Mani, K., Sandgren, S., Welch, J., Cheng, F., Svensson, K., Persson, L. & Belting, M., 2007, In: Molecular Cancer Therapeutics. 6, 2, p. 782-788Research output: Contribution to journal › Article › peer-review
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2006
Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.
Mani, K., Cheng, F. & Fransson, L-Å., 2006, In: Glycobiology. 16, 12, p. 1251-1261Research output: Contribution to journal › Article › peer-review
Open Access -
Copper-dependent co-internalization of the prion protein and glypican-1.
Cheng, F., Lindqvist, J., Haigh, C. L., Brown, D. R. & Mani, K., 2006, In: Journal of Neurochemistry. 98, 5, p. 1445-1457Research output: Contribution to journal › Article › peer-review
File184 Downloads (Pure) -
Defective NO-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts.
Mani, K., Cheng, F. & Fransson, L-Å., 2006, In: Glycobiology. 16, 8, p. 711-718Research output: Contribution to journal › Article › peer-review
Open Access -
Regioselective reductive openings of acetals; Mechanistic details and synthesis of fluorescently labeled compounds
Johnsson, R., Mani, K., Cheng, F. & Ellervik, U., 2006, In: Journal of Organic Chemistry. 71, 9, p. 3444-3451Research output: Contribution to journal › Article › peer-review
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2005
The amyloid precursor protein(APP)of Alzheimer's disease and its paralog APLP2 modulate the Cu/Zn-NO-catalyzed degradation of glypican-1 heparan sulfate In vivo.
Cappai, R., Cheng, F., Ciccotosto, G. D., Needham, B. E., Masters, C. L., Multhaup, G., Fransson, L-Å. & Mani, K., 2005, In: Journal of Biological Chemistry. 280, 14, p. 13913-13920Research output: Contribution to journal › Article › peer-review
Open Access -
2004
Involvement of GPI-linked ceruloplasmin in the Cu/Zn-NO-dependent degradation of glypican-1 heparan sulfate in Rat C6 glioma cells.
Mani, K., Cheng, F., Havsmark, B., David, S. & Fransson, L-Å., 2004, In: Journal of Biological Chemistry. 279, 13, p. 12918-12923Research output: Contribution to journal › Article › peer-review
Open Access -
Novel aspects of glypican glycobiology.
Fransson, L-Å., Belting, M., Cheng, F., Jönsson, M., Mani, K. & Sandgren, S., 2004, In: Cellular and Molecular Life Sciences. 61, 9, p. 1016-1024Research output: Contribution to journal › Review article › peer-review
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The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1.
Mani, K., Cheng, F., Sandgren, S., Van Den Born, J., Havsmark, B., Ding, K. & Fransson, L-Å., 2004, In: Glycobiology. 14, 7, p. 599-607Research output: Contribution to journal › Article › peer-review
Open Access -
The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis
Sandgren, S., Wittrup, A., Cheng, F., Jönsson, M., Eklund, E., Busch, S. & Belting, M., 2004, In: Journal of Biological Chemistry. 279, 17, p. 17951-17956Research output: Contribution to journal › Article › peer-review
Open Access -
Tumor attenuation by 2(6-hydroxynaphthyl)-{beta}-D-xylopyranoside requires priming of heparan sulfate and nuclear targeting of the products.
Mani, K., Belting, M., Ellervik, U., Falk, N., Svensson Birkedal, G., Sandgren, S., Cheng, F. & Fransson, L-Å., 2004, In: Glycobiology. 14, 5, p. 387-397Research output: Contribution to journal › Article › peer-review
Open Access -
2003
Glypican-1 is a vehicle for polyamine uptake in mammalian cells. A pivotal role for nitrosothiol-derived nitric oxide.
Belting, M., Mani, K., Jönsson, M., Cheng, F., Sandgren, S., Jonsson, S., Ding, K., Delcros, J-G. & Fransson, L-Å., 2003, In: Journal of Biological Chemistry. 278, 47, p. 47181-47189Research output: Contribution to journal › Article › peer-review
Open Access -
Prion or amyloid-b-derived Cu(II)- or free Zn(II)-ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.
Mani, K., Cheng, F., Havsmark, B., Jönsson, M., Belting, M. & Fransson, L-Å., 2003, In: Journal of Biological Chemistry. 278, 40, p. 38956-38965Research output: Contribution to journal › Article › peer-review
Open Access -
2002
Copper-dependent autocleavage of glypican-1heparan sulfate by nitric oxide derived fromintrinsic nitrosothiols.
Ding, K., Mani, K., Cheng, F., Belting, M. & Fransson, L-Å., 2002, In: Journal of Biological Chemistry. 277, 36, p. 33353-33360Research output: Contribution to journal › Article › peer-review
Open Access -
Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1 containing endosomes.
Cheng, F., Mani, K., Van Den Born, J., Ding, K., Belting, M. & Fransson, L-Å., 2002, In: Journal of Biological Chemistry. 277, 46, p. 44431-44439Research output: Contribution to journal › Article › peer-review
Open Access -
Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide: role for cell-surface proteoglycans.
Sandgren, S., Cheng, F. & Belting, M., 2002, In: Journal of Biological Chemistry. 277, 41, p. 38877-38883Research output: Contribution to journal › Article › peer-review
Open Access -
2001
Differences in the uptake and nuclear localization of anti-proliferative heparan sulfate between human lung fibroblasts and human lung carcinoma cells
Cheng, F., Petersson, P., Arroyo-Yanguas, Y. & Westergren-Thorsson, G., 2001, In: Journal of Cellular Biochemistry. 83, 4, p. 597-606Research output: Contribution to journal › Article › peer-review
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1997
Binding, internalization, and degradation of antiproliferative heparan sulfate by human embryonic lung fibroblasts
Arroyo-Yanguas, Y., Cheng, F., Isaksson, A., Fransson, L. A., Malmström, A. & Westergren-Thorsson, G., 1997 Mar 15, In: Journal of Cellular Biochemistry. 64, 4, p. 595-604 10 p.Research output: Contribution to journal › Article › peer-review
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Development and application of strategies for the analysis of modification patterns in chondroitin and dermatan sulphate
Cheng, F., 1997, Fang Cheng, Dept. Cell and Molecular Biology, Medical Faculty, Lund University.,. 110 p.Research output: Thesis › Doctoral Thesis (monograph)
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1994
Patterns of uronosyl epimerization and 4-/6-O-sulphation in chondroitin/dermatan sulphate from decorin and biglycan of various bovine tissues
Cheng, F., Heinegård, D., Malmström, A., Schmidtchen, A., Yoshida, K. & Fransson, L-Å., 1994, In: Glycobiology. 4, 5, p. 685-696Research output: Contribution to journal › Article › peer-review