Research output per year
Research output per year
- 37 results
Search results
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2023
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Cheng, F., Hansson, V. C., Georgolopoulos, G. & Mani, K., 2023, In: Oncotarget. 14, 1, p. 219-235 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells
Cheng, F., Fransson, L. Å. & Mani, K., 2023 Apr 1, In: Glycobiology. 33, 4, p. 325-341 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Complex modulation of cytokine-induced α-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells
Cheng, F., Fransson, L. Å. & Mani, K., 2022 Apr 1, In: Glycobiology. 32, 4, p. 333-342Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1
Cheng, F., Fransson, L. Å. & Mani, K., 2021 Aug 7, In: Glycobiology. 31, 7, p. 800-811 12 p.Research output: Contribution to journal › Article › peer-review
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2020
Proinflammatory cytokines induce accumulation of glypican-1-derived heparan sulfate and the C-terminal fragment of β-cleaved APP in autophagosomes of dividing neuronal cells
Cheng, F., Fransson, L. Å. & Mani, K., 2020, In: Glycobiology. 30, 8, p. 539-549 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
The cyanobacterial neurotoxin β-N-methylamino-L-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells
Cheng, F., Fransson, L. Å. & Mani, K., 2019, In: Experimental Cell Research. 379, 2, p. 172-181 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Common traffic routes for imported spermine and endosomal glypican-1-derived heparan sulfate in fibroblasts
Cheng, F., Fransson, L. Å. & Mani, K., 2018, In: Experimental Cell Research. 364, 2, p. 133-142Research output: Contribution to journal › Article › peer-review
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2017
Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1
Cheng, F., Fransson, L. Å. & Mani, K., 2017, In: Experimental Cell Research. 360, 2, p. 171-179Research output: Contribution to journal › Article › peer-review
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Nucleolin is a nuclear target of heparan sulfate derived from glypican-1
Cheng, F., Belting, M., Fransson, L. Å. & Mani, K., 2017, In: Experimental Cell Research. 354, 1, p. 31-39Research output: Contribution to journal › Article › peer-review
Open AccessFile185 Downloads (Pure) -
2016
Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.
Cheng, F., Bourseau-Guilmain, E., Belting, M., Fransson, L-Å. & Mani, K., 2016, In: Glycobiology. 26, 6, p. 623-634 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile430 Downloads (Pure) -
2015
Rapid nuclear transit and impaired degradation of amyloid beta and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.
Cheng, F., Fransson, L-Å. & Mani, K., 2015, In: Glycobiology. 25, 5, p. 548-556Research output: Contribution to journal › Article › peer-review
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Suppression of glypican-1 autodegradation by NO-deprivation correlates with nuclear accumulation of amyloid beta in normal fibroblasts.
Cheng, F., Fransson, L-Å. & Mani, K., 2015, In: Glycoconjugate Journal. 32, 9, p. 675-684Research output: Contribution to journal › Article › peer-review
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2014
APP/APLP2 expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.
Cheng, F., Cappai, R., Lidfeldt, J., Belting, M., Fransson, L-Å. & Mani, K., 2014, In: Journal of Biological Chemistry. 289, 30, p. 20871-20878Research output: Contribution to journal › Article › peer-review
File142 Downloads (Pure) -
2013
Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products
Cheng, F., Ruscher, K., Fransson, L-Å. & Mani, K., 2013, In: Glycobiology. 23, 12, p. 1510-1519Research output: Contribution to journal › Article › peer-review
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2012
Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage.
Cheng, F., Svensson Birkedal, G., Fransson, L-Å. & Mani, K., 2012, In: Glycobiology. 22, 11, p. 1480-1485Research output: Contribution to journal › Article › peer-review
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2011
Suppression of amyloid beta a11-immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, no-catalyzed degradation.
Cheng, F., Cappai, R., Ciccotosto, G. D., Svensson Birkedal, G., Multhaup, G., Fransson, L-Å. & Mani, K., 2011, In: Journal of Biological Chemistry. 286, 31, p. 27559-27572Research output: Contribution to journal › Article › peer-review
File115 Downloads (Pure) -
2009
Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.
Cheng, F., Johnsson, R., Nilsson, J., Fransson, L-Å., Ellervik, U. & Mani, K., 2009, In: Cancer Letters. 273, p. 148-154Research output: Contribution to journal › Article › peer-review
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2008
Involvement of glypican-1 autoprocessing in scrapie infection
Lofgren, K., Cheng, F., Fransson, L-Å., Bedecs, K. & Mani, K., 2008, In: European Journal of Neuroscience. 28, 5, p. 964-972Research output: Contribution to journal › Article › peer-review
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2007
Heparan sulfate degradation products can associate with oxidized proteins and proteasomes.
Mani, K., Cheng, F. & Fransson, L-Å., 2007, In: Journal of Biological Chemistry. 282, 30, p. 21934-21944Research output: Contribution to journal › Article › peer-review
Open Access -
HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.
Mani, K., Sandgren, S., Welch, J., Cheng, F., Svensson, K., Persson, L. & Belting, M., 2007, In: Molecular Cancer Therapeutics. 6, 2, p. 782-788Research output: Contribution to journal › Article › peer-review
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2006
Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.
Mani, K., Cheng, F. & Fransson, L-Å., 2006, In: Glycobiology. 16, 12, p. 1251-1261Research output: Contribution to journal › Article › peer-review
Open Access -
Copper-dependent co-internalization of the prion protein and glypican-1.
Cheng, F., Lindqvist, J., Haigh, C. L., Brown, D. R. & Mani, K., 2006, In: Journal of Neurochemistry. 98, 5, p. 1445-1457Research output: Contribution to journal › Article › peer-review
File184 Downloads (Pure) -
Defective NO-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts.
Mani, K., Cheng, F. & Fransson, L-Å., 2006, In: Glycobiology. 16, 8, p. 711-718Research output: Contribution to journal › Article › peer-review
Open Access -
Regioselective reductive openings of acetals; Mechanistic details and synthesis of fluorescently labeled compounds
Johnsson, R., Mani, K., Cheng, F. & Ellervik, U., 2006, In: Journal of Organic Chemistry. 71, 9, p. 3444-3451Research output: Contribution to journal › Article › peer-review
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2005
The amyloid precursor protein(APP)of Alzheimer's disease and its paralog APLP2 modulate the Cu/Zn-NO-catalyzed degradation of glypican-1 heparan sulfate In vivo.
Cappai, R., Cheng, F., Ciccotosto, G. D., Needham, B. E., Masters, C. L., Multhaup, G., Fransson, L-Å. & Mani, K., 2005, In: Journal of Biological Chemistry. 280, 14, p. 13913-13920Research output: Contribution to journal › Article › peer-review
Open Access -
2004
Involvement of GPI-linked ceruloplasmin in the Cu/Zn-NO-dependent degradation of glypican-1 heparan sulfate in Rat C6 glioma cells.
Mani, K., Cheng, F., Havsmark, B., David, S. & Fransson, L-Å., 2004, In: Journal of Biological Chemistry. 279, 13, p. 12918-12923Research output: Contribution to journal › Article › peer-review
Open Access -
The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1.
Mani, K., Cheng, F., Sandgren, S., Van Den Born, J., Havsmark, B., Ding, K. & Fransson, L-Å., 2004, In: Glycobiology. 14, 7, p. 599-607Research output: Contribution to journal › Article › peer-review
Open Access -
The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis
Sandgren, S., Wittrup, A., Cheng, F., Jönsson, M., Eklund, E., Busch, S. & Belting, M., 2004, In: Journal of Biological Chemistry. 279, 17, p. 17951-17956Research output: Contribution to journal › Article › peer-review
Open Access -
Tumor attenuation by 2(6-hydroxynaphthyl)-{beta}-D-xylopyranoside requires priming of heparan sulfate and nuclear targeting of the products.
Mani, K., Belting, M., Ellervik, U., Falk, N., Svensson Birkedal, G., Sandgren, S., Cheng, F. & Fransson, L-Å., 2004, In: Glycobiology. 14, 5, p. 387-397Research output: Contribution to journal › Article › peer-review
Open Access -
2003
Glypican-1 is a vehicle for polyamine uptake in mammalian cells. A pivotal role for nitrosothiol-derived nitric oxide.
Belting, M., Mani, K., Jönsson, M., Cheng, F., Sandgren, S., Jonsson, S., Ding, K., Delcros, J-G. & Fransson, L-Å., 2003, In: Journal of Biological Chemistry. 278, 47, p. 47181-47189Research output: Contribution to journal › Article › peer-review
Open Access -
Prion or amyloid-b-derived Cu(II)- or free Zn(II)-ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.
Mani, K., Cheng, F., Havsmark, B., Jönsson, M., Belting, M. & Fransson, L-Å., 2003, In: Journal of Biological Chemistry. 278, 40, p. 38956-38965Research output: Contribution to journal › Article › peer-review
Open Access -
2002
Copper-dependent autocleavage of glypican-1heparan sulfate by nitric oxide derived fromintrinsic nitrosothiols.
Ding, K., Mani, K., Cheng, F., Belting, M. & Fransson, L-Å., 2002, In: Journal of Biological Chemistry. 277, 36, p. 33353-33360Research output: Contribution to journal › Article › peer-review
Open Access -
Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1 containing endosomes.
Cheng, F., Mani, K., Van Den Born, J., Ding, K., Belting, M. & Fransson, L-Å., 2002, In: Journal of Biological Chemistry. 277, 46, p. 44431-44439Research output: Contribution to journal › Article › peer-review
Open Access -
Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide: role for cell-surface proteoglycans.
Sandgren, S., Cheng, F. & Belting, M., 2002, In: Journal of Biological Chemistry. 277, 41, p. 38877-38883Research output: Contribution to journal › Article › peer-review
Open Access -
2001
Differences in the uptake and nuclear localization of anti-proliferative heparan sulfate between human lung fibroblasts and human lung carcinoma cells
Cheng, F., Petersson, P., Arroyo-Yanguas, Y. & Westergren-Thorsson, G., 2001, In: Journal of Cellular Biochemistry. 83, 4, p. 597-606Research output: Contribution to journal › Article › peer-review
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1997
Binding, internalization, and degradation of antiproliferative heparan sulfate by human embryonic lung fibroblasts
Arroyo-Yanguas, Y., Cheng, F., Isaksson, A., Fransson, L. A., Malmström, A. & Westergren-Thorsson, G., 1997 Mar 15, In: Journal of Cellular Biochemistry. 64, 4, p. 595-604 10 p.Research output: Contribution to journal › Article › peer-review
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1994
Patterns of uronosyl epimerization and 4-/6-O-sulphation in chondroitin/dermatan sulphate from decorin and biglycan of various bovine tissues
Cheng, F., Heinegård, D., Malmström, A., Schmidtchen, A., Yoshida, K. & Fransson, L-Å., 1994, In: Glycobiology. 4, 5, p. 685-696Research output: Contribution to journal › Article › peer-review