Research output per year
Research output per year
Personal profile
Research
The AMP-activated protein kinase (AMPK) is a highly conserved and ubiquitously expressed protein, sensesing and regulating cellular energy levels. Its activation by existing and candidate diabetic drugs forms a mechanistic basic for the treatment of type 2 diabetes (T2D) due to predicted beneficial effects in liver and muscle tissue. Thus, pharmacological activation of AMPK is a suggested and intensely studied strategy for the treatment of insulin resistance and diabetes. The effect of AMPK activation in adipose tissue however remains poorly understood.
The inability of subcutaneous tissue to adequately store excess energy is a major underlying cause of insulin resistance and type 2 diabetes (T2D). Due to its ability to inhibit lipolysis and stimulate glucose uptake and fatty acid (FA) synthesis (lipogenesis), insulin is known as the most important regulator of lipid storage. The exact mechanisms for how insulin stimulates FA synthesis are not known however, presvious results suggest an involvement of insulin-induced AMPK inhibition.
The overall aim of my research is to investigate the effects AMPK activation has on adipocyte metabolism and characterize the effect insulin has on AMPK activity and the underlying mechanism.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Cell and Molecular Biology
- Endocrinology and Diabetes
Free keywords
- adipose tissue, insulin, AMPK-activated protein kinase,
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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EHD2 regulates plasma membrane integrity and downstream insulin receptor signalling events
Neuhaus, M., Fryklund, C., Taylor, H., Borreguero-Muñoz, A., Kopietz, F., Ardalani, H., Rogova, O., Stirrat, L., Bremner, S. K., Spégel, P., Bryant, N. J., Gould, G. W. & Stenkula, K. G., 2023, In: Molecular Biology of the Cell. 34, 12, ar124.Research output: Contribution to journal › Article › peer-review
Open Access -
Metabolic control by AMPK in white adipose tissue
Göransson, O., Kopietz, F. & Rider, M. H., 2023, In: Trends in Endocrinology and Metabolism. 34, 11, p. 704-717 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes
Säll, J., Lindahl, M., Fritzen, A. M., Fryklund, C., Kopietz, F., Nyberg, E., Warvsten, A., Morén, B., Foretz, M., Kiens, B., Stenkula, K. G. & Göransson, O., 2023, In: Obesity. 31, 10, p. 2515-2529Research output: Contribution to journal › Article › peer-review
Open Access -
AMPKβ isoform expression patterns in various adipocyte models and in relation to body mass index
Kopietz, F., Degerman, E. & Göransson, O., 2022 Aug 4, In: Frontiers in Physiology. 13, 928964.Research output: Contribution to journal › Article › peer-review
Open Access -
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
Ahwazi, D., Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, A. S., Gräsle, P., Alshuweishi, Y., Treebak, J. T., Salt, I. P., Göransson, O., Zeqiraj, E., Scott, J. W. & Sakamoto, K., 2021 Aug, In: Biochemical Journal. 478, 15, p. 2977-2997 21 p.Research output: Contribution to journal › Article › peer-review
Open Access
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Adipocyte plasma membrane composition and its role in insulin sensitivity
Kopietz, F., Stenkula, K. & Spégel, P.
2021/12/01 → …
Project: Research
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The Role of Amp-Activated Protein Kinase in the Regulation of Fatty Acid Synthesis in Adipocytes
Göransson, O., Kopietz, F., Lindahl, M. & Vaváková, M.
Dir Albert Påhlssons stiftelse för forskning och välgörenhet, Diabetesfonden - Stiftelsen Svenska Diabetesförbundets Forskningsfond, Diabetes Wellness Network Sweden, Insamlingsstiftelsen
2022/01/01 → 2023/12/31
Project: Research
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The role of AMPK and SIK isoforms in human adipose tissue and diabetes pathogenesis
Göransson, O., Kopietz, F., Lindahl, M., Negoita, F. & Stenkula, K.
2018/01/01 → 2021/12/31
Project: Research
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AMP-activated protein kinase in adipose tissue
Göransson, O., Kopietz, F., Lindahl, M. & Degerman, E.
2017/04/01 → 2021/05/01
Project: Dissertation
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The role of SGK1 in primary adipocytes
Franziska Kopietz (Joint first/primary/lead supervisor)
2022 Oct 31 → 2023 MayActivity: Examination and supervision › Supervision
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The role of AMPK in the regulation of fatty acid synthesis in adipocytes
Franziska Kopietz (Joint first/primary/lead supervisor)
2021 Jun 7 → 2021 Jul 31Activity: Examination and supervision › Supervision
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Evaluation of the effect of different AMPK activators on glucose uptake in rat and human adipocytes
Franziska Kopietz (Presenter)
2018 Oct 1Activity: Talk or presentation › Presentation
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The importance of phosphorylation of AMP-activated protein kinase on S485 in primary rat adipocytes
Franziska Kopietz (Joint first/primary/lead supervisor)
2018 Jun 11 → 2018 Aug 3Activity: Examination and supervision › Supervision
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Effect of AMPK activation on lipolysis in adipocytes from three different species
Franziska Kopietz (Presenter)
2017 Sept 11Activity: Talk or presentation › Presentation