Fredrik Ghosh

Fredrik Ghosh

Professor, consultant

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Biomimetic Retinal Tissue Engineering
Revelation - Restitution - Replacement

Traditionally, neuronal research is conducted on single cell preparations after enzymatical and mechanical disruption of the tissue. A more pertinent approach to the complex central nervous system is to consider cells, extracellular matrix, and cell junctions as a tissue continuum which together form a functional unit through which mechanical and biochemical information is bidirectionally communicated. This research program is focused on cell interactions and their significance in relation to retinal structure and function in health and disease, and how these interactions can be modified by tissue engineering. We present a novel hypothesis on perturbation of the tissue continuum as a common mechanism behind retinal degenerative disease, and also investigate how synthetic polymer gels can replace the natural vitreous and interact with the retina to restitute vision after surgery. Finally, a model of cell replacement therapy is explored in advanced cases of retinal degenerative disease where, in contrast to stem cell therapies, we strive to retain the retinal tissue continuum to optimize donor tissue survival and synapse formation between donor and host.

Specific aims

To reveal novel retinal regulatory and pathological mechanisms in health and disease by exploring retinal biomechanics in relation to biochemistry

To restitute function and structure in retinal disease after surgery by exploring potential vitreous substitute candidate compounds

To replace neurons lost in advanced degenerative disease by retinal transplantation

UKÄ subject classification

  • Ophthalmology


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