Research output per year
Research output per year
Research output
- 1 - 50 out of 56 results
Search results
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2024
Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr
Kurata, T., Takegawa, M., Ohira, T., Syroegin, E. A., Atkinson, G. C., Johansson, M. J. O., Polikanov, Y. S., Garcia-Pino, A., Suzuki, T. & Hauryliuk, V., 2024 Nov 15, In: Science Advances. 10, 46, eadr9624.Research output: Contribution to journal › Article › peer-review
Open Access -
Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects
Huang, W., Baliga, C., Aleksandrova, E. V., Atkinson, G., Polikanov, Y. S., Vázquez-Laslop, N. & Mankin, A. S., 2024 Nov 8, In: EMBO Reports. 25, 11, p. 5194-5211 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanisms of neutralization of toxSAS from toxin-antitoxin modules
Dominguez-Molina, L., Kurata, T., Cepauskas, A., Echemendia-Blanco, D., Zedek, S., Talavera-Perez, A., Atkinson, G. C., Hauryliuk, V. & Garcia-Pino, A., 2024 Jun 4, (E-pub ahead of print) In: Nature Chemical Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated quality control
Svetlov, M. S., Dunand, C. F., Nakamoto, J. A., Atkinson, G. C., Safdari, H. A., Wilson, D. N., Vázquez-Laslop, N. & Mankin, A. S., 2024 Feb, In: Molecular Cell. 84, 4, p. 715-726.e5Research output: Contribution to journal › Article › peer-review
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A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases
Tesson, F., Planel, R., Egorov, A. A., Georjon, H., Vaysset, H., Brancotte, B., Néron, B., Mordret, E., Atkinson, G. C., Bernheim, A. & Cury, J., 2024, In: Peer Community Journal. 4, e91.Research output: Contribution to journal › Article › peer-review
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A role for the S4-domain containing protein YlmH in ribosome-associated quality control in Bacillus subtilis
Takada, H., Paternoga, H., Fujiwara, K., Nakamoto, J. A., Park, E. N., Dimitrova-Paternoga, L., Beckert, B., Saarma, M., Tenson, T., Buskirk, A. R., Atkinson, G. C., Chiba, S., Wilson, D. N. & Hauryliuk, V., 2024, In: Nucleic Acids Research. 52, 14, gkae399.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems
Mets, T., Kurata, T., Ernits, K., Johansson, M. J. O., Craig, S. Z., Evora, G. M., Buttress, J. A., Odai, R., Wallant, K. C., Nakamoto, J. A., Shyrokova, L., Egorov, A. A., Doering, C. R., Brodiazhenko, T., Laub, M. T., Tenson, T., Strahl, H., Martens, C., Harms, A. & Garcia-Pino, A. & 2 others, , 2024, In: Cell Host and Microbe. 32, 7, p. 1059-1073.e8Research output: Contribution to journal › Article › peer-review
Open Access -
Resolution of ribosomal stalling by EF-P and ABCF ATPases YfmR and YkpA/YbiT
Takada, H., Fujiwara, K., Atkinson, G. C., Chiba, S. & Hauryliuk, V., 2024, In: Nucleic Acids Research. 52, 16, p. 9854-9866Research output: Contribution to journal › Article › peer-review
Open Access -
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it
Aleksandrova, E. V., Wu, K. J. Y., Tresco, B. I. C., Syroegin, E. A., Killeavy, E. E., Balasanyants, S. M., Svetlov, M. S., Gregory, S. T., Atkinson, G. C., Myers, A. G. & Polikanov, Y. S., 2024, In: Nature Chemical Biology. 20, 7, p. 867-876Research output: Contribution to journal › Article › peer-review
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2023
The native ABC-F proteins of Staphylococcus aureus do not contribute to intrinsic resistance against ribosome-targeting antibacterial drugs
Galarion, L. H., Trigwell, J., Mohamad, M., Nakamoto, J. A., Clarke, J. E., Atkinson, G. C. & O'neill, A. J., 2023 Oct, In: Journal of Antimicrobial Chemotherapy. 78, 10, p. 2601-2603 3 p.Research output: Contribution to journal › Article › peer-review
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The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems
Ernits, K., Saha, C. K., Brodiazhenko, T., Chouhan, B., Shenoy, A., Buttress, J. A., Duque-Pedraza, J. J., Bojar, V., Nakamoto, J. A., Kurata, T., Egorov, A. A., Shyrokova, L., Johansson, M. J. O., Mets, T., Rustamova, A., Džigurski, J., Tenson, T., Garcia-Pino, A., Strahl, H. & Elofsson, A. & 2 others, , 2023 Aug 15, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 33, p. 1-12 e2305393120.Research output: Contribution to journal › Article › peer-review
Open Access -
The structure of DarB in complex with RelNTD reveals nonribosomal activation of Rel stringent factors
Ainelo, A., Caballero-Montes, J., Bulvas, O., Ernits, K., Coppieters 't Wallant, K., Takada, H., Craig, S. Z., Mazzucchelli, G., Zedek, S., Pichová, I., Atkinson, G. C., Talavera, A., Martens, C., Hauryliuk, V. & Garcia-Pino, A., 2023 Jan 18, In: Science Advances. 9, 3, p. 1-14 eade4077.Research output: Contribution to journal › Article › peer-review
Open Access -
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR
Obana, N., Takada, H., Crowe-McAuliffe, C., Iwamoto, M., Egorov, A. A., Wu, K. J. Y., Chiba, S., Murina, V., Paternoga, H., Tresco, B. I. C., Nomura, N., Myers, A. G., Atkinson, G. C., Wilson, D. N. & Hauryliuk, V., 2023, In: Nucleic Acids Research. 51, 9, p. 4536-4554Research output: Contribution to journal › Article › peer-review
Open Access -
Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint
Tamman, H., Ernits, K., Roghanian, M., Ainelo, A., Julius, C., Perrier, A., Talavera, A., Ainelo, H., Dugauquier, R., Zedek, S., Thureau, A., Pérez, J., Lima-Mendez, G., Hallez, R., Atkinson, G. C., Hauryliuk, V. & Garcia-Pino, A., 2023, In: Nature Chemical Biology. 19, 3, p. 334-345Research output: Contribution to journal › Article › peer-review
Open Access -
uORF4u: a tool for annotation of conserved upstream open reading frames
Egorov, A. A. & Atkinson, G. C., 2023, In: Bioinformatics. 39, 5, btad323.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Direct activation of a bacterial innate immune system by a viral capsid protein
Zhang, T., Tamman, H., Coppieters 't Wallant, K., Kurata, T., LeRoux, M., Srikant, S., Brodiazhenko, T., Cepauskas, A., Talavera, A., Martens, C., Atkinson, G. C., Hauryliuk, V., Garcia-Pino, A. & Laub, M. T., 2022 Dec 1, In: Nature. 612, 7938, p. 132–140 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Context-based sensing of orthosomycin antibiotics by the translating ribosome
Mangano, K., Marks, J., Klepacki, D., Saha, C. K., Atkinson, G. C., Vázquez-Laslop, N. & Mankin, A. S., 2022 Nov, In: Nature Chemical Biology. 18, 11, p. 1277-1286 10 p.Research output: Contribution to journal › Article › peer-review
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A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains
Kurata, T., Saha, C. K., Buttress, J. A., Mets, T., Brodiazhenko, T., Turnbull, K. J., Awoyomi, O. F., Oliveira, S. R. A., Jimmy, S., Ernits, K., Delannoy, M., Persson, K., Tenson, T., Strahl, H., Hauryliuk, V. & Atkinson, G. C., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 6, p. 1-12 e2102212119.Research output: Contribution to journal › Article › peer-review
Open Access -
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp
Hiraku, T., Mandell, Z. F., Yakhnin, H., Glazyrina, A., Chiba, S., Kurata, T., Wu, K. J. Y., Tresco, B. I. C., Myers, A. G., Atkinson, G., Babitzke, P. & Hauryliuk, V., 2022, In: Nucleic Acids Research. 50, 11, p. 6174-6189 gkac497.Research output: Contribution to journal › Article › peer-review
Open Access -
Sal-type ABC-F proteins: Intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci
Mohamad, M., Nicholson, D., Saha, C. K., Hauryliuk, V., Edwards, T. A., Atkinson, G. C., Ranson, N. A. & O'Neill, A. J., 2022, In: Nucleic Acids Research. 50, 4, p. 2128-2142 gkac058.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes
Koller, T. O., Turnbull, K. J., Vaitkevicius, K., Crowe-McAuliffe, C., Roghanian, M., Bulvas, O., Nakamoto, J. A., Kurata, T., Julius, C., Atkinson, G. C., Johansson, J., Hauryliuk, V. & Wilson, D. N., 2022, In: Nucleic Acids Research. 50, 19 , p. 11285-11300Research output: Contribution to journal › Article › peer-review
Open Access -
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
Crowe-McAuliffe, C., Murina, V., Turnbull, K. J., Huch, S., Kasari, M., Takada, H., Nersisyan, L., Sundsfjord, A., Hegstad, K., Atkinson, G. C., Pelechano, V., Wilson, D. N. & Hauryliuk, V., 2022, In: Nature Communications. 13, 1860.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
Crowe-McAuliffe, C., Murina, V., Turnbull, K. J., Kasari, M., Mohamad, M., Polte, C., Takada, H., Vaitkevicius, K., Johansson, J., Ignatova, Z., Atkinson, G. C., O’Neill, A. J., Hauryliuk, V. & Wilson, D. N., 2021 Dec, In: Nature Communications. 12, 1, 3577.Research output: Contribution to journal › Article › peer-review
Open Access -
RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
Kurata, T., Brodiazhenko, T., Alves Oliveira, S. R., Roghanian, M., Sakaguchi, Y., Turnbull, K. J., Bulvas, O., Takada, H., Tamman, H., Ainelo, A., Pohl, R., Rejman, D., Tenson, T., Suzuki, T., Garcia-Pino, A., Atkinson, G. C. & Hauryliuk, V., 2021 Aug 5, In: Molecular Cell. 81, 15, p. 3160-3170. e1-e9Research output: Contribution to journal › Article › peer-review
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(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains
Roghanian, M., Van Nerom, K., Takada, H., Caballero-Montes, J., Tamman, H., Kudrin, P., Talavera, A., Dzhygyr, I., Ekström, S., Atkinson, G. C., Garcia-Pino, A. & Hauryliuk, V., 2021, In: Molecular Cell. 81, 16, p. 3310-3322.e6Research output: Contribution to journal › Article › peer-review
Open Access -
FlaGs and webFlaGs: discovering novel biology through the analysis of gene neighbourhood conservation
Saha, C. K., Sanches Pires, R., Brolin, H., Delannoy, M. & Atkinson, G. C., 2021, In: Bioinformatics. 37, 9, p. 1312-1314Research output: Contribution to journal › Article › peer-review
Open Access -
RqcH and RqcP catalyze processive poly-alanine synthesis in a reconstituted ribosome-associated quality control system
Takada, H., Crowe-McAuliffe, C., Polte, C., Sidorova, Z. Y., Murina, V., Atkinson, G. C., Konevega, A. L., Ignatova, Z., Wilson, D. N. & Hauryliuk, V., 2021, In: Nucleic Acids Research. 49, 14, p. 8355-8369 gkab589.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
Crowe-McAuliffe, C., Takada, H., Murina, V., Polte, C., Kasvandik, S., Tenson, T., Ignatova, Z., Atkinson, G. C., Wilson, D. N. & Hauryliuk, V., 2021, In: Molecular Cell. 81, 1, p. 115-126Research output: Contribution to journal › Article › peer-review
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Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance
Svetlov, M. S., Syroegin, E. A., Aleksandrova, E. V., Atkinson, G. C., Gregory, S. T., Mankin, A. S. & Polikanov, Y. S., 2021, In: Nature Chemical Biology. 17, p. 412-420Research output: Contribution to journal › Article › peer-review
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2020
A widespread toxin−antitoxin system exploiting growth control via alarmone signaling
Jimmy, S., Saha, C. K., Kurata, T., Stavropoulos, C., Oliveira, S. R. A., Koh, A., Cepauskas, A., Takada, H., Rejman, D., Tenson, T., Strahl, H., Garcia-Pino, A., Hauryliuk, V. & Atkinson, G. C., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 19, p. 10500-10510Research output: Contribution to journal › Article › peer-review
Open Access -
Elevated levels of VCA0117 (VasH) in response to external signals activate the type VI secretion system of Vibrio cholerae O1 El Tor A1552
Seibt, H., Aung, K. M., Ishikawa, T., Sjöström, A., Gullberg, M., Atkinson, G. C., Wai, S. N. & Shingler, V., 2020, In: Environmental Microbiology. 22, 10, p. 4409-4423Research output: Contribution to journal › Article › peer-review
Open Access -
The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes
Takada, H., Roghanian, M., Murina, V., Dzhygyr, I., Murayama, R., Akanuma, G., Atkinson, G. C., Garcia-Pino, A. & Hauryliuk, V., 2020, In: Frontiers in Microbiology. 11, p. 1-16 277.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life
Murina, V., Kasari, M., Takada, H., Hinnu, M., Saha, C. K., Grimshaw, J. W., Seki, T., Reith, M., Putrinš, M., Tenson, T., Strahl, H., Hauryliuk, V. & Atkinson, G. C., 2019, In: Journal of Molecular Biology. 431, 18, p. 3568-3590Research output: Contribution to journal › Article › peer-review
Open Access -
A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling
Kasari, V., Pochopien, A. A., Margus, T., Murina, V., Turnbull, K., Zhou, Y., Nissan, T., Graf, M., Nováček, J., Atkinson, G. C., Johansson, M. J. O., Wilson, D. N. & Hauryliuk, V., 2019, In: Nucleic Acids Research. 47, 16, p. 8807-8820Research output: Contribution to journal › Article › peer-review
Open Access -
Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae
Kasari, V., Margus, T., Atkinson, G. C., Johansson, M. J. O. & Hauryliuk, V., 2019, In: Scientific Reports. 9, p. 1-10 3037.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR
Crowe-McAuliffe, C., Graf, M., Huter, P., Takada, H., Abdelshahid, M., Nováček, J., Murina, V., Atkinson, G. C., Гaврилюк, B. & Wilson, D. N., 2018 Sept 4, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. 8978-8983 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest
Murina, V., Kasari, M., Hauryliuk, V. & Atkinson, G. C., 2018 Apr 20, In: Nucleic Acids Research. 46, 7, p. 3753-3763 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA
Beljantsev, J., Kudrin, P., Andresen, L., Shingler, V., Atkinson, G. C., Tenson, T. & Hauryliuk, V., 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 14, p. 3726-3731Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Aim-less translation: Loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis
Kuzmenko, A., Derbikova, K., Salvatori, R., Tankov, S., Atkinson, G. C., Tenson, T., Ott, M., Kamenski, P. & Hauryliuk, V., 2016 Jan 5, In: Scientific Reports. 6, 18749.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
The evolutionary and functional diversity of classical and lesser-known cytoplasmic and organellar translational GTPases across the tree of life
Atkinson, G. C., 2015, In: BMC Genomics. 16, 78.Research output: Contribution to journal › Article › peer-review
Open Access -
2014
A conserved proline triplet in Val-tRNA synthetase and the origin of elongation factor P
Starosta, A. L., Lassak, J., Peil, L., Atkinson, G. C., Woolstenhulme, C. J., Virumäe, K., Buskirk, A., Tenson, T., Remme, J., Jung, K. & Wilson, D. N., 2014, In: Cell Reports. 9, 2, p. 476-483Research output: Contribution to journal › Article › peer-review
Open Access -
An evolutionary ratchet leading to loss of elongation factors in eukaryotes
Atkinson, G. C., Kuzmenko, A., Chicherin, I., Soosaar, A., Tenson, T., Carr, M., Kamenski, P. & Hauryliuk, V., 2014, In: BMC Evolutionary Biology. 14, p. 1-9 35.Research output: Contribution to journal › Article › peer-review
Open Access -
Macrolide antibiotics allosterically predispose the ribosome for translation arrest
Sothiselvam, S., Liu, B., Han, W., Ramu, H., Klepacki, D., Atkinson, G. C., Brauer, A., Remm, M., Tenson, T., Schulten, K., Vázquez-Laslop, N. & Mankin, A. S., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9804-9809Research output: Contribution to journal › Article › peer-review
Open Access -
Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site
Starosta, A. L., Lassak, J., Peil, L., Atkinson, G. C., Virumäe, K., Tenson, T., Remme, J., Jung, K. & Wilson, D. N., 2014, In: Nucleic Acids Research. 42, 16, p. 10711-10719Research output: Contribution to journal › Article › peer-review
Open Access -
2013
Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase
Atkinson, G. C., Hansen, L. H., Tenson, T., Rasmussen, A., Kirpekar, F. & Vester, B., 2013 Aug, In: Antimicrobial Agents and Chemotherapy. 57, 8, p. 4019-4026Research output: Contribution to journal › Article › peer-review
Open Access -
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P
Peil, L., Starosta, A. L., Lassak, J., Atkinson, G. C., Virumäe, K., Spitzer, M., Tenson, T., Jung, K., Remme, J. & Wilson, D. N., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15265-15270Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)
Li, W., Atkinson, G. C., Thakor, N. S., Allas, U., Lu, C. C., Yan Chan, K., Tenson, T., Schulten, K., Wilson, K. S., Hauryliuk, V. & Frank, J., 2013, In: Nature Communications. 4, p. 1-8 1477.Research output: Contribution to journal › Article › peer-review
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2012
Lys34 of translation elongation factor EF-P is hydroxylated by YfcM
Peil, L., Starosta, A. L., Virumäe, K., Atkinson, G. C., Tenson, T., Remme, J. & Wilson, D. N., 2012 Aug, In: Nature Chemical Biology. 8, p. 695-697Research output: Contribution to journal › Article › peer-review
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Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae
Atkinson, G. C., Kuzmenko, A., Kamenski, P., Vysokikh, M. Y., Lakunina, V., Tankov, S., Smirnova, E., Soosaar, A., Tenson, T. & Hauryliuk, V., 2012 Jul, In: Nucleic Acids Research. 40, 13, p. 6122-6134 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
SeqFIRE: a web application for automated extraction of indel regions and conserved blocks from protein multiple sequence alignments
Ajawatanawong, P., Atkinson, G. C., Watson-Haigh, N. S., Mackenzie, B. & Baldauf, S. L., 2012 Jul, In: Nucleic Acids Research. 40, Web Server issue, p. W340-7Research output: Contribution to journal › Article › peer-review
Open Access