Giuseppe Giordano

2024

The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study

Eriksen, R., White, M. C., Dawed, A. Y., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, E. L., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A. & Mahajan, A. & 26 others, McDonald, T. J., Kokkola, T., Rutters, F., Beulens, J., Muilwijk, M., Blom, M., Elders, P., Hansen, T. H., Fernandez-Tajes, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Holst, J. J., Thomsen, H. S., Ridderstråle, M., Bell, J. D., Adamski, J., Franks, P. W., Hansen, T., Holmes, E., Frost, G. & Pearson, E. R., 2024 Sept, In: Journal of Clinical Endocrinology and Metabolism. 109, 9, p. e1697-e1707

Research output: Contribution to journal › Article › peer-review

Open Access

We’ve discovered a gene for trust – here’s how it could be linked to good health

Giordano, G., 2024 Jun 7, The Conversation.

Research output: Contribution to specialist publication or newspaper › Specialist publication article › Popular science

Open Access

A Federated Database for Obesity Research: An IMI-SOPHIA Study

Delfin, C., Dragan, I., Kuznetsov, D., Tajes, J. F., Smit, F., Coral, D. E., Farzaneh, A., Haugg, A., Hungele, A., Niknejad, A., Hall, C., Jacobs, D., Marek, D., Fraser, D. P., Thuillier, D., Ahmadizar, F., Mehl, F., Pattou, F., Burdet, F. & Hawkes, G. & 28 others, Arts, I. C. W., Blanch, J., Van Soest, J., Fernández-Real, J. M., Boehl, J., Fink, K., van Greevenbroek, M. M. J., Kavousi, M., Minten, M., Prinz, N., Ipsen, N., Franks, P. W., Ramos, R., Holl, R. W., Horban, S., Duarte-Salles, T., Tran, V. D. T., Raverdy, V., Leal, Y., Lenart, A., Pearson, E., Sparsø, T., Giordano, G. N., Ioannidis, V., Soh, K., Frayling, T. M., Le Roux, C. W. & Ibberson, M., 2024 Feb, In: Life. 14, 2, 262.

Research output: Contribution to journal › Article › peer-review

Open Access

A genome-wide association study of social trust in 33,882 Danish blood donors

Sequeros, C. B., Kalamajski, S., Giordano, G. N., Pedersen, O. B. V. & DBDS Genomic Consortium, 2024, In: Scientific Reports. 14, 1, 1402.

Research output: Contribution to journal › Article › peer-review

Open Access

Subclassification of obesity for precision prediction of cardiometabolic diseases

Coral, D. E., Smit, F., Farzaneh, A., Gieswinkel, A., Tajes, J. F., Sparsø, T., Delfin, C., Bauvin, P., Wang, K., Temprosa, M., De Cock, D., Blanch, J., Fernández-Real, J. M., Ramos, R., Ikram, M. K., Gomez, M. F., Kavousi, M., Panova-Noeva, M., Wild, P. S. & van der Kallen, C. & 9 others, Adriaens, M., van Greevenbroek, M., Arts, I., Le Roux, C., Ahmadizar, F., Frayling, T. M., Giordano, G. N., Pearson, E. R. & Franks, P. W., 2024, (E-pub ahead of print) In: Nature Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus

Lundgaard, A. T., Burdet, F., Siggaard, T., Westergaard, D., Vagiaki, D., Cantwell, L., Röder, T., Vistisen, D., Sparsø, T., Giordano, G. N., Ibberson, M., Banasik, K. & Brunak, S., 2023 Aug, In: PLoS Computational Biology. 19, 8 August, e1011403.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A. & Burdet, F. & 46 others, Canouil, M., Dragan, I., Elders, P. J. M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S. K., Shaw, J. L., Cabrera, O., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Lim, G. E., Estall, J., Ibberson, M., Beulens, J. W. J., 't Hart, L. M., Pearson, E. R. & Rutter, G. A., 2023 May 3, In: Nature Communications. 14, p. 1-18 2533.

Research output: Contribution to journal › Article › peer-review

Open Access

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Coral, D. E., Fernandez-Tajes, J., Tsereteli, N., Pomares-Millan, H., Fitipaldi, H., Mutie, P. M., Atabaki-Pasdar, N., Kalamajski, S., Poveda, A., Miller-Fleming, T. W., Zhong, X., Giordano, G. N., Pearson, E. R., Cox, N. J. & Franks, P. W., 2023 Feb, In: Nature Metabolism. 5, 2, p. 237–247 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Allesøe, R. L., Ridderstråle, M., Giordano, G. N., Franks, P. W., Groop, L., Pasdar, N. A., Fitipaldi, H., Kurbasic, A., Mutie, P., Pomares-Millan, H., Klintenberg, M., Abdalla, M. & IMI DIRECT Consortium, 2023, In: Nature Biotechnology.

Research output: Contribution to journal › Article › peer-review

Open Access

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Brown, A. A., Giordano, G. N., Ridderstråle, M., Franks, P. W., Atabaki-Pasdar, N., Fitipaldi, H., Groop, L., Klintenberg, M., Pomares-Millan, H., Viñuela, A. & IMI DIRECT Consortium, 2023, In: Nature Communications. 14, 5062.

Research output: Contribution to journal › Article › peer-review

Open Access

Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women

Mutie, P. M., Pomares-Milan, H., Atabaki-Pasdar, N., Coral, D., Fitipaldi, H., Tsereteli, N., Tajes, J. F., Franks, P. W. & Giordano, G. N., 2023, In: Diabetologia. 66, 2, p. 321-335

Research output: Contribution to journal › Article › peer-review

Open Access

Who benefits most from outpatient lifestyle intervention? An IMI-SOPHIA study on pediatric individuals living with overweight and obesity

Prinz, N., Pomares-Millan, H., Dannemann, A., Giordano, G. N., Joisten, C., Körner, A., Weghuber, D., Weihrauch-Blüher, S., Wiegand, S., Holl, R. W. & Lanzinger, S., 2023, In: Obesity. 31, 9, p. 2375-2385 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Estimating the Direct Effect between Dietary Macronutrients and Cardiometabolic Disease, Accounting for Mediation by Adiposity and Physical Activity

Pomares-Millan, H., Atabaki-Pasdar, N., Coral, D., Johansson, I., Giordano, G. N. & Franks, P. W., 2022 Mar 1, In: Nutrients. 14, 6, 1218.

Research output: Contribution to journal › Article › peer-review

Open Access

Can Bureaucrats Break Trust? Testing Cultural and Institutional Theories of Trust with Chinese Panel Data

Fairbrother, M., Mewes, J., Wilkes, R., Wu, C. & Giordano, N., 2022, In: Socius: Sociological Research for a Dynamic World. 8

Research output: Contribution to journal › Article › peer-review

Open Access

Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality

Pomares-Millan, H., Poveda, A., Atabaki Pasdar, N., Johansson, I. (Contributor), Björk, J., Ohlsson, M., Giordano, N. & Franks, P., 2022, In: Nutrients. 14, 15, p. 1-13 3171.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S. & Viñuela, A. & 17 others, Mahajan, A., McDonald, T. J., Kokkola, T., Vangipurapu, J., Cederberg, H., Laakso, M., Rutters, F., Elders, P. J. M., Koopman, A. D. M., Beulens, J. W., Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H., Mari, A. & IMI DIRECT Consortium, 2021 Sept 1, In: Diabetes. 70, 9, p. 2092-2106 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Chinese Citizen Satisfaction with Government Performance during COVID-19

Wu, C., Shi, Z., Wilkes, R., Wu, J., Gong, Z., He, N., Xiao, Z., Zhang, X., Lai, W., Zhou, D., Zhao, F., Yin, X., Xiong, P., Zhou, H., Chu, Q., Cao, L., Tian, R., Tan, Y., Yang, L. & He, Z. & 3 others, Fairbrother, M., Mewes, J. & Giordano, G. N., 2021, In: Journal of Contemporary China. 30, 132, p. 930-944 15 p.

Research output: Contribution to journal › Article › peer-review

Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study

Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Elders, P., Festa, A., Hansen, M. K., van der Heijden, A. A., Aly, D. M., Kim, M., Kuznetsov, D., Mehl, F., Klose, C. & Simons, K. & 15 others, Pavo, I., Pullen, T. J., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Quigley, C. L., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W., 't Hart, L. M. & Pearson, E. R., 2021, In: Diabetes. 70, 11, p. 2683-2693

Research output: Contribution to journal › Article › peer-review

Experiences matter: A longitudinal study of individual-level sources of declining social trust in the United States

Mewes, J., Fairbrother, M., Giordano, N., Wu, C. & Wilkes, R., 2021, In: Social Science Research. 95, 102537.

Research output: Contribution to journal › Article › peer-review

Open Access

Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study

Atabaki-Pasdar, N., Pomares-Millan, H., Koivula, R. W., Tura, A., Brown, A., Viñuela, A., Agudelo, L., Coral, D., van Oort, S., Allin, K., Chabanova, E., Cederberg, H., De Masi, F., Elders, P., Tajes, J. F., Forgie, I. M., Hansen, T. H., Heggie, A., Jones, A. & Kokkola, T. & 30 others, Mahajan, A., McDonald, T. J., McEvoy, D., Tsirigos, K., Teare, H., Vangipurapu, J., Vestergaard, H., Adamski, J., Beulens, J. W., Brunak, S., Dermitzakis, E., Hansen, T., Hattersley, A. T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Rutters, F., Schwenk, J. M., Walker, M., Giordano, G. N., Ohlsson, M., Gupta, R., Mari, A., McCarthy, M. I., Thomas, E. L., Bell, J. D., Pavo, I., Pearson, E. R. & Franks, P. W., 2021, medRxiv, (medRxiv).

Research output: Working paper/Preprint › Preprint (in preprint archive)

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

Bizzotto, R., Jennison, C., Jones, A. G., Kurbasic, A., Tura, A., Kennedy, G., Bell, J. D., Thomas, E. L., Frost, G., Eriksen, R., Koivula, R. W., Brage, S., Kaye, J., Hattersley, A. T., Heggie, A., McEvoy, D., 't Hart, L. M., Beulens, J. W., Elders, P. & Musholt, P. B. & 28 others, Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H., Lundgaard, A. T., Thomsen, H. S., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J., Kokkola, T., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., Franks, P. W., Walker, M., Pearson, E. R., Mari, A. & IMI DIRECT Consortium, 2021, In: Diabetes Care. 44, 2, p. 511-518 8 p.

Research output: Contribution to journal › Article › peer-review

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Festa, A., Hansen, M. K., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., Pavo, I. & Pullen, T. J. & 13 others, Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido-Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., 't Hart, L. M. & Pearson, E. R., 2021, In: Diabetologia. 64, 9, p. 1982-1989 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

RHAPSODY, Biomarkers and Novel Clinical Trial design in type 2 diabetes (T2D) and prediabetes

Adams, R., Daly, N., Robertson, E. & Giordano, G. N., 2021, In: Endocrinology, Diabetes and Metabolism. 4, 2

Research output: Contribution to journal › Article › peer-review

Open Access

2020

An investigation of causal relationships between prediabetes and vascular complications

Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W., 2020 Dec 1, In: Nature Communications. 11, 1, 4592.

Research output: Contribution to journal › Article › peer-review

Open Access

Trust, happiness and mortality: Findings from a prospective US population-based survey

Miething, A., Mewes, J. & Giordano, G. N., 2020 May, In: Social Science & Medicine . 252, 112809.

Research output: Contribution to journal › Article › peer-review

Open Access

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

Koivula, R. W., Atabaki-Pasdar, N., Giordano, G. N., White, T., Adamski, J., Bell, J. D., Beulens, J., Brage, S., Brunak, S., De Masi, F., Dermitzakis, E. T., Forgie, I. M., Frost, G., Hansen, T., Hansen, T. H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M. & Mari, A. & 15 others, McDonald, T. J., Pedersen, O., Rutters, F., Schwenk, J. M., Teare, H. J. A., Thomas, E. L., Vinuela, A., Mahajan, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Pavo, I., Franks, P. W. & IMI DIRECT Consortium, 2020 Apr, In: Diabetologia. 63, 4, p. 744-756 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

Eriksen, R., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J. & Kokkola, T. & 17 others, Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G., 2020, In: EBioMedicine. 58, 102932.

Research output: Contribution to journal › Article › peer-review

Open Access

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

Obura, M., Beulens, J. W. J., Slieker, R., Koopman, A. D. M., Hoekstra, T., Nijpels, G., Elders, P., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A., McCarthy, M. I. & Walker, M. & 19 others, Heggie, A., McDonald, T. J., Perry, M. H., De Masi, F., Brunak, S., Mahajan, A., Giordano, G. N., Kokkola, T., Dermitzakis, E., Viñuela, A., Pedersen, O., Schwenk, J. M., Adamski, J., Teare, H. J. A., Pearson, E. R., Franks, P. W., 't Hart, L. M., Rutters, F. & IMI DIRECT Consortium, 2020, In: PLoS ONE. 15, 11, e0242360.

Research output: Contribution to journal › Article › peer-review

Open Access

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

et al., Atabaki Pasdar, N., Ohlsson, M., Pomares-Millan, H., Koivula, R., Kurbasic, A., Mutie, P., Fitipaldi, H., Fernandez Tajes, J., Giordano, N. & Franks, P., 2020, In: PLoS Medicine. 17, 6, p. e1003149

Research output: Contribution to journal › Article › peer-review

Open Access

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

et al., Gudmundsdottir, V., Giordano, N., Koivula, R., Ridderstråle, M., Franks, P. & Brunak, S., 2020, In: Genome Medicine. 12, 1, 109.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Motivations for data sharing—views of research participants from four European countries: A DIRECT study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 2019 Jan 30, In: European Journal of Human Genetics.

Research output: Contribution to journal › Article › peer-review

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Wilman, H. R., Atabaki Pasdar, N., Franks, P., Giordano, G., Pomares-Millan, H., Fitipaldi, H., Mutie, P., Klintenberg, M., Yaghootkar, H. & IMI DIRECT Consortium, 2019, In: Journal of Hepatology. 71, 3, p. 594-602

Research output: Contribution to journal › Article › peer-review

Open Access

Sharing data for future research—engaging participants’ views about data governance beyond the original project: a DIRECT Study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 2019, In: Genetics in Medicine. 21, 5, p. 1131-1138

Research output: Contribution to journal › Article › peer-review